China Biggest Manufacturer factory sales 4-Methoxyphenol CAS 150-76-5

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4-Methoxyphenol Basic information Product Name: 4-Methoxyphenol Synonyms: Eastman HQMME;ethermonomethyliqued’hydroquinone;Hqmme;Hydroquinone methyl ether;hydroquinonemethylether;Leucobasal;Leucodine b;leucodineb CAS: 150-76-5 MF: C7H8O2 MW: 124.14 EINECS: 205-769-8 Product Categories: Liquid Crystal intermediates;Phenol&Thiophenol&Mercaptan;API intermediates;Biochemistry;Building Blocks for Liquid Crystals;Functional Materials;Aromatic Ethers;Phenols (Building Blocks for Liquid Crystals);Reagents for Oligosaccharide Synthesis;Aromatics;Building Blocks;C6 to C8;Chemical Synthesis;organic synthesis;Organic Building Blocks;Oxygen Compounds;Phenols;150-76-5 Mol File: 150-76-5.mol   4-Methoxyphenol Chemical Properties Melting point  56 °C Boiling point  243 °C(lit.) density  1,55 g/cm3 vapor density  4.3 (vs air) vapor pressure  <0.01 mm Hg ( 20 °C) refractive index  1.5286 (estimate) Fp  >230 °F storage temp.  Store below +30°C. solubility  Soluble in acetone, ethyl acetate, ethanol, ether, benzene and carbon tetrachloride. pka 10.21(at 25℃) form  Liquid color  Clear colorless to pale yellow PH 5.1 (30g/l, H2O, 20℃) Odor Threshold 0.0027ppm Water Solubility  40 g/L (25 ºC) BRN  507924 Stability: Stable. Combustible. Incompatible with halogens, oxidizing agents. InChIKey NWVVVBRKAWDGAB-UHFFFAOYSA-N CAS DataBase Reference 150-76-5(CAS DataBase Reference) NIST Chemistry Reference Mequinol(150-76-5) EPA Substance Registry System p-Methoxyphenol (150-76-5)   Safety Information Hazard Codes  Xn Risk Statements  22-36-43 Safety Statements  24/25-26-37/39-46 WGK Germany  1 RTECS  SL7700000 Autoignition Temperature 789 °F TSCA  Yes HS Code  29095090 Hazardous Substances Data 150-76-5(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 1600 mg/kg MSDS Information Provider Language 4-Methoxyphenol English SigmaAldrich English ACROS English ALFA English   4-Methoxyphenol Usage And Synthesis Chemical Properties 4-Methoxyphenol is a colorless to white, waxy solid with an odor of caramel and phenol. A combustible solid. Uses Inhibitor for acrylic monomers; stabilizer for chlorinated hydrocarbons and ethyl cellulose; UV inhibitor Uses 4-methoxyphenol may be used in the synthesis of butylated hydroxy anisoles via alkylation with methyl tert-butyl ether over a non-zeolitic solid acidic catalyst. This process is eco-friendly when compared to the Friedel-Crafts alkylation reaction. 4-MP may also react with aqueous nitrous acid to form 2-nitro-4-methoxyphenol and benzoquinone in varying ratios depending on the reaction conditions. 4-MP can be used as a building block in designing β-cyclodextrin 4-methoxyphenol conjugates that can be potential ligands for drug complexation. Uses 4-Methoxyphenol is an active ingredient and used in dermatology. It is employed as a pharmaceutical drug in skin depigmentation. It is used as polymerization inhibitors. For example, in the radical polymerization of acryaltes and styrene monomers. It is also used as an intermediate in the preparationagrochemicals, liquid crystals. It acts as a stabilizer for the formulation of inks, toners and adhesives. It is mainly used as an additive for textile and leather industries. Preparation 4-Methoxyphenol was produced according to Oxidation with H2O2 and a Diselenide catalyst. p-Anisaldehyde (50 mmol) is dissolved in CH2Cl2 (100mL) and (o-NO2PhSe)2 (2 mmol) and 30% H2O2 (13mL, 128 mmol) are added. The mixture is stirred magnetically at room temperature (water bath) for 30 minutes. Insoluble catalyst is removed by filtration and washed with CH2Cl2 (20mL) and water (20mL). It can be reused after drying. To the filtrate and washings, water (100mL) is added, and the layers are separated after shaking. The organic layer is washed subsequently with 10% NaHSO3 (100mL), 10% Na2CO3 (100mL), water (100mL) and dried over Na2SO4. 4-methoxyphenol is obtained by alkaline hydrolysis of the residue. Yield: 93%. Indications Mequinol (4-hydroxyanisole) is a substrate of the enzyme tyrosinase and acts as a competitive inhibitor of melanogenesis. Synthesis Reference(s) The Journal of Organic Chemistry, 42, p. 1479, 1977 DOI: 10.1021/jo00428a054 Synthesis, p. 751, 1983 DOI: 10.1055/s-1983-30501 Tetrahedron Letters, 34, p. 7667, 1993 DOI: 10.1016/S0040-4039(00)61534-4 General Description Pink crystals or white waxy solid. Air & Water Reactions Sensitive to moisture. Water soluble. Reactivity Profile 4-Methoxyphenol can react with oxidizing materials. Hazard Eye irritant and skin damage. Health Hazard 4-Methoxyphenol is expected to cause liver and renal toxicity with narcosis, but only at high levels of exposure. Fire Hazard Combustible Safety Profile Poison by intraperitoneal route. A skin irritant. When heated to decomposition it emits acrid smoke and fumes. See also ETHERS. Shipping UN3335 Aviation regulated solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. Purification Methods Crystallise 4-methoxyphenol from *benzene, pet ether or H2O, and dry it under vacuum over P2O5 at room temperature. Sublime it in vacuo. [Wolfenden et al. J Am Chem Soc 109 463 1987, Beilstein 6 IV 5717.]   4-Methoxyphenol Preparation Products And Raw materials Raw materials Ethanol-->Methanol-->Sulfuric acid-->Hydroquinone-->1,4-Benzoquinone-->Silane, (1,1-dimethylethyl)(4-methoxyphenoxy)dimethyl--->4-Chloroanisole-->4-ALLYLOXYANISOLE-->4-Methoxyphenylboronic acid-->4-Bromoanisole Preparation Products N-Isopropylacrylamide-->Butylated hydroxyanisole-->5-METHOXYBENZOFURAN-2-CARBOXYLIC ACID, ETHYL ESTER-->5-Methoxybenzofuran-->5-Methoxybenzofuran-2-carboxylic acid-->5-Methoxysalicylic acid-->2-METHOXY-5-(2'-ETHYLHEXYLOXY)BENZENE-1&-->N-NONYL ACRYLATE-->2-Hydroxy-5-methoxybenzaldehyde-->6-METHOXY-2-OXO-2H-CHROMENE-3-CARBOXYLIC ACID-->Disperse Red 146-->4-methoxyphenyl benzoate-->3-Bromo-2,5-dimethoxyaniline-->2,3-EPOXYPROPYL-4-METHOXYPHENYL ETHER-->Disperse Red 146

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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