The world Biggest Manufacturer factory sales L-Epicatechin CAS 490-46-0

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L-Epicatechin Basic information Product Name: L-Epicatechin Synonyms: 3,3',4',5,7-PENTAHYDROXY-FLAVANE;3,3',4',5,7-PENTAHYROXYFLAVONE;3,3',4',5,7-PENTAHYDROXYFLAVAN;(2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3,5,7-TRIOL;(-)-epicatecho;(-)-epicatechol;(-)-EPICATECHIN;(+)-EPICATECHIN CAS: 490-46-0 MF: C15H14O6 MW: 290.27 EINECS: 207-710-1 Product Categories: chemical reagent;pharmaceutical intermediate;Pharmaceutical Raw Materials;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chiral;Aromatics;Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals Mol File: 490-46-0.mol   L-Epicatechin Chemical Properties Melting point  240 °C (dec.)(lit.) alpha  -55～-65゜(D/20℃)(c=1,CH3OH) Boiling point  629.2 °C density  1.593±0.06 g/cm3(Predicted) storage temp.  -20°C pka 9.54±0.10(Predicted) form  neat Water Solubility  Soluble in water or alcohol Merck  13,1912 BRN  92760 InChIKey PFTAWBLQPZVEMU-UKRRQHHQSA-N CAS DataBase Reference 490-46-0(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  3 RTECS  KB3745000 F  10-23 HS Code  29329990 MSDS Information Provider Language L-Epicatechin English SigmaAldrich English   L-Epicatechin Usage And Synthesis Description ( )-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH (Item No. 14805) radicals in a cell-free assay when used at a concentration of 5 μM. ( )-Epicatechin inhibits COX-1 (IC50 = 3.2 μM). It acts synergistically with epigallocatechin gallate (Item No. 70935) to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 μM. ( )-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation. Chemical Properties white to light yellow crystal powde Uses Potent antioxidant and antineoplastic agent. Uses Catechin is a polyphenolic flavonoid that has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro lipid peroxidation assays. ( )-Epicatechin is a 2R,3R stereoisomer of catechin. Like catechin, ( )-epicatechin is a powerful antioxidant. It inhibits cyclooxygenase 1 (IC50 = 3.2 μM). Also, at 100 μM, ( )-epicatechin induces apoptosis in human adenocarcinoma PC-9 cells and stimulates the inhibition of tumor necrosis factor-α release from BALB-c/3T3 cells treated with epigallocatechin gallate. Uses An antioxidant and natural product from green tea Definition ChEBI: A catechin with (2R,3R)-configuration. General Description ( )-Epicatechin (EC) belongs to the group of flavanols and is abundantly present in cacao and cacao products. The chemical structure of EC includes an oxygenated heterocycle with a 4-hydroxyl group linked with two aromatic rings. Biochem/physiol Actions This antioxidant is found in chocolate. (-)-Epicatechin is linked with cardiovascular effects. It is considered as a dependable standard due to its availability in cacao seeds and cocoa products. The halogenating activity of myeloperoxidase can be restored by (-)-epicatechin.   L-Epicatechin Preparation Products And Raw materials Preparation Products Procyanidin B1

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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