China Largest Manufacturer factory sales Pachymic Acid CAS 29070-92-6

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Pachymic acid Basic information Description Uses Product Name: Pachymic acid Synonyms: 3-ACETYLTUMULOSIC ACID;Pachymic acid (3-O-Acetyltumulosic acid);PACHYMIC ACID;(3b,16a)-3-(Acetyloxy)-16-hydroxy-24-methylenelanost-8-en-21-oic acid;24-methylene-,(3β,16α)-;3-O-Acetyltumulosic acid;Lanost-8-en-21-oic acid, 3-(acetyloxy)-16-hydroxy-;3β-Acetyloxy-16α-hydroxy-24-methylenelanost-8-en-21-oic acid CAS: 29070-92-6 MF: C33H52O5 MW: 528.76 EINECS:   Product Categories: Natural metabolites;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 29070-92-6.mol   Pachymic acid Chemical Properties Melting point  300 °C(Solv: methanol (67-56-1); acetone (67-64-1)) Boiling point  612.2±55.0 °C(Predicted) density  1.10±0.1 g/cm3(Predicted) storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere solubility  Methanol (Slightly), Pyridine (Slightly) pka 4.65±0.10(Predicted) form  Solid color  White to Off-White Stability: Hygroscopic   Safety Information MSDS Information   Pachymic acid Usage And Synthesis Description Pachymic acid (PA) is a lanostane-type triterpenoid from Poriacocos, which is an important component in traditional Chinese medicine. Previous studies have shown that PA possesses anti-emetic, anti-inflammatory and anticancer properties. It has been demonstrated that PA is able to inhibit the proliferation and invasion of pancreatic cancer cells by decreasing MMP-7 expression. PA was able to activate reactive oxygen species (ROS)-dependent JUN N-terminal kinase mitochondrial and endoplasmic reticulum stress pathways following cell cycle arrest at G2/M phase and cell apoptosis occurred in lung cancer cells. PA reduced proliferation and induced apoptosis through inactivation of AKT signaling and downregulation of AKT downstream protein expression in prostate cancer cells. Another study demonstrated that PA is able to stimulate glucose uptake by enhancing the expression and translocation of glucose transporter type 4. However, the therapeutic effects and potential mechanisms of PA on gastric cancer are poorly understood and therefore remain to be evaluated. Uses Pachymic acid (PA) is a natural triterpenoid known to inhibit the phospholipase A2 (PLA(2)) family of arachidonic acid (AA)-producing enzymes, PA-treatment decreases bad phosphorylation, increases Bcl-2 phosphorylation, and activates caspases-9 and -3, it also decreases the expression and activation of proteins within the AKT signal pathway. suggests that PA initiates apoptosis through mitochondria dysfunction and influences apoptosis by reducing prostaglandin. Pachymic acid can exhibit antiinflammatory and anticancer properties, it can inhibit cell growth and modulate arachidonic acid metabolism in nonsmall cell lung cancer A549 cells by its inhibition of MAPKs and NF-kappaB signaling pathways; it can impair breast cancer cell invasion by suppressing nuclear factor-κB-dependent matrix metalloproteinase-9 expression. Pachymic acid has antioxidant activity, affects the removal effect of reactive oxygen species formation as did N-acetyl-L-cysteine and inhibits nuclear factor-κB translocation, it can mitigate the unfavorable conditions induced by AH Plus stimuli, therefore, the use of pachymic acid is suggested to prevent the complications of oral diseases such as inflammation and alveolar destruction of the oral cavity. Uses Pachymic Acid is a natural triterpene extract which suppresses invasiveness of pancreatic cancer cells through the downregulation of MMP-7. Anticancer Research Extracted from Poria cocos, pachymic acid (PA) is a tri-terpenoid (a lanostanetype), which is reported to have anticancerous properties. NCI-H460 and NCI-H23cells, the lung cancer cell lines, were studied for the effect of pachymic acid.Expression of a major UPR target gene-regulated protein, CHOP, was upregulatedresulting in cell apoptosis after PA treatment. It was discovered that ROS inhibitorsblocked the ER stress activation induced by PA. The results indicated that ROSproduction is also regulated by PA in lung cancer cells (Cheng et al. 2015; Jun et al.2015). As per the studies conducted on MIA PaCa-2 and PANC-1 cell lines,PA-induced apoptosis in pancreatic cancer cell resistant to gemcitabine wasdependent on in vivo and in vitro activation of ER stress. PA can be exploited for itsanticancer effects for treatment of pancreatic cancer resistant to chemotherapy(Cheng et al. 2015).   Pachymic acid Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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