China Largest Manufacturer factory sales 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy CAS 2226-96-2

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4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Basic information Product Name: 4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Synonyms: HYDROXY-TEMPO;4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE-N-OXYL;4-HYDROXY-2,2,6,6-TETRAMETHYL-PIPERIDINOOXY;4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINE 1-OXYL;4-HYDROXY-2,2,6,6-TETRAMETHYL-1-PIPERIDIN-1-YLOXY;4-HYDROXY-2,2,6,6-TETRAMETHYL-1-PIPERIDINYLOXY, FREE RADICAL;4-HYDROXY-2,2,6,6-TETRAMETHYL-PIPERIDINOOXY, FREE RADICAL;4-HYDROXY-2,2,6,6-TETRAMETHYLPIPERIDINYLOXY CAS: 2226-96-2 MF: C9H18NO2* MW: 172.24 EINECS: 218-760-9 Product Categories: Inhibitors;Analytical Chemistry;ESR Spectrometry;Spin Labels;Heterocycles;Nitric Oxide Reagents;Spin Labeling Compounds Mol File: 2226-96-2.mol   4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Chemical Properties Melting point  69-71 °C(lit.) Boiling point  302.58°C (rough estimate) density  1.0402 (rough estimate) refractive index  1.4350 (estimate) Fp  146°(295°F) storage temp.  2-8°C solubility  1670g/l form  Crystals or Crystalline Powder color  Orange PH 8.2 (20g/l, H2O, 20℃) Water Solubility  soluble Merck  14,9141 BRN  1422990 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey FAPCFNWEPHTUQK-UHFFFAOYSA-N CAS DataBase Reference 2226-96-2(CAS DataBase Reference) NIST Chemistry Reference 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl-(2226-96-2) EPA Substance Registry System 1-Piperidinyloxy, 4-hydroxy-2,2,6,6-tetramethyl- (2226-96-2)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-36/38 Safety Statements  26-36-37/39-36/37/39-27 WGK Germany  1 RTECS  TN8991000 TSCA  Yes HS Code  29333999 Hazardous Substances Data 2226-96-2(Hazardous Substances Data) Toxicity LD50 oral in rat: 1053mg/kg MSDS Information Provider Language 2,2,6,6-Tetramethyl freeagaoxy-4-piperidyl English SigmaAldrich English ACROS English ALFA English   4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Usage And Synthesis Description TEMPOL is a piperidine nitroxide and spin label with superoxide dismutase (SOD) mimetic activity. It inhibits lipid peroxidation in rat liver microsomes with 50% inhibition of microsomal lipid peroxidation (IP50) values of 117, 61, and 381 μM for peroxidation induced by iron plus NADPH, iron plus ascorbate, and t-butylhydroperoxide, respectively. TEMPOL (1 mM) inhibits production of superoxide anions by 92% via a xanthine-xanthine oxidase reaction in vitro. It reduces mean arterial pressure and heart rate in spontaneously hypertensive rats (ED50s = 70 and 63 μmol/kg, respectively) when administered intravenously. TEMPOL is a cell-permeable spin label that has been used to quantify intracellular oxygen in various cell types by electron spin resonance (ESR) spectroscopy. Chemical Properties solid Uses A free radical scavenger Uses Spin label for EPR studies; phase transfer dehydration catalyst; antioxidant; inhibitor of olefin free radical polymerization. Uses Tempol, a water-soluble piperidine nitroxide derivative having nonspecific radical-scavenging and superoxide dismutase (SOD) activity, protects cultured aerobic, but not hypoxic, cells against radiation-induced killing. Protection does not depend on intracellular thiols and does not involve O2-depletion. Tempol reacts with peroxyl radicals and can also oxidize DNA-bound metal ions, thereby interfering with OH generation. Synthesis Reference(s) Synthetic Communications, 19, p. 3509, 1989 DOI: 10.1080/00397918908052760 General Description 4-Hydroxy-TEMPO is a 4-substituted 2,2,6,6-tetramethylpiperidyl-1-oxy (TEMPO) derivative. It is a low-molecular weight compound and has been proposed as superoxide dismutase mimic. Biological Activity Superoxide scavenger that displays neuroprotective, anti-inflammatory and analgesic effects. References 1) Lipman et al. (2006), Neuroprotective effects if the stable nitroxide compound Tempol in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in the Nerve Growth Factor-differentiated model of pheochromocytoma PC12 cells; Eur. J. Pharmacol., 549 50 2) Guron et al. (2006), Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats; J. Hypertens., 24 387 3) Samuni and Barenholz (1997), Gamma-irradiation damage to liposomes differing in composition and their protection by nitroxides; Free Radic. Biol. Med., 23 972 4) Bernardy et al. (2017), Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice; Biomed. Res. Int., 2017 9584819 5) De Blasio et al. (2017), The superoxide dismutase mimetic tempol blunts diabetes-induced upregulation of NADPH oxidase and endoplasmic reticulum stress in a rat model of diabetic nephropathy; Eur. J. Pharmacol., 807 12   4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy Preparation Products And Raw materials Preparation Products 6-Hydroxy-2-naphthaldehyde

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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