China Largest Manufacturer factory sales 2'-Deoxycytidine CAS 951-77-9

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2'-Deoxycytidine monohydrate Basic information Product Name: 2'-Deoxycytidine monohydrate Synonyms: 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-;2'-DEOXYCYTIDINE FREE BASE;4-amino-1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyrimidin-2-one;2''-Deoxycytidine (and/or unspecified salts);2'-Deoxycytidine monohydrate;2''-DEOXYCYTIDINE (CYTOSINE): (DEOXYRIBOSIDE);2-DEOXYCYTIDINE extrapure;2'-Deoxycytidine ,98% CAS: 951-77-9 MF: C9H13N3O4 MW: 227.22 EINECS: 213-454-1 Product Categories: Bases & Related Reagents;Carbohydrates & Derivatives;FINE Chemical & INTERMEDIATES;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Pharmaceutical Mol File: 951-77-9.mol   2'-Deoxycytidine monohydrate Chemical Properties Melting point  209-211 °C(lit.) Boiling point  368.93°C (rough estimate) density  1.3171 (rough estimate) refractive index  59 ° (C=1, H2O) storage temp.  -20°C solubility  H2O: 50 mg/mL, clear, colorless pka 14.03±0.60(Predicted) form  Crystalline Powder color  White Water Solubility  Soluble in water, DMSO. BRN  87567 CAS DataBase Reference 951-77-9(CAS DataBase Reference) NIST Chemistry Reference Deoxycytidine(951-77-9) EPA Substance Registry System Cytidine, 2'-deoxy- (951-77-9)   Safety Information Safety Statements  24/25 WGK Germany  3 RTECS  HA3800000 F  10 TSCA  Yes HS Code  29349990 MSDS Information Provider Language 2'-Deoxycytidine monohydrate English SigmaAldrich English   2'-Deoxycytidine monohydrate Usage And Synthesis Chemical Properties White crystalline powder Uses A deoxyribonucleoside Uses 2 -Deoxycytidine (deoxyC) is one of the deoxynucleosides which after phosphorylation to dCTP is used to synthesis DNA via various DNA polymerases or reverse transcriptases. 2 -Deoxycytidine (deoxyC) is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2 -deoxyuridine. 2 -Deoxycytidine is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). Definition ChEBI: A pyrimidine 2'-deoxyribonucleoside having cytosine as the nucleobase. General Description 2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine. Biochem/physiol Actions 2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker. Safety Profile Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Purify 2'-deoxycytidine by recrystallisation from MeOH/Et2O or EtOH and dry it in air. [NMR: Miles J Am Chem Soc 85 1007 1963, UV: Fox & Shugar Biochim Biophys Acta 9 369 1952.] The hydrochloride crystallises from H2O/EtOH and has m 174o(dec, 169-173o). [Walker & Butler Can J Chem 34 1168 1956.] The picrate has m 208o(dec). [Fox et al. J Am Chem Soc 83 4066 1961, Beilstein 25 III/IV 3662.]   2'-Deoxycytidine monohydrate Preparation Products And Raw materials Preparation Products 2-AMino-9-[5-(hydroxyMethyl)oxolan-2-yl]-3H-purin-6-one-->2'-Deoxycytidine-5'-monophosphoric acid-->DMT-DCYTIDINE (N6-BENZOYL) CYANOETHYL PHOSPHORAMIDITE)-->5'-O-(4,4'-DIMETHOXYTRITYL)-N4-ACETYL-2'-DEOXYCYTIDINE-->PHTHALAMIDE-->5-Bromo-2'-deoxycytidine-->5'-O-Dimethoxytrityl-N-benzoyl-desoxycytidine

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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