China Largest Manufacturer factory sales Tetrabutylammonium bromide CAS 1643-19-2

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Tetrabutylammonium bromide Basic information Physical and Chemical Properties Application Uses preparation Toxicity Product Name: Tetrabutylammonium bromide Synonyms: 1-Butanaminium, N,N,N-tributyl-, bromide;1-Butanaminium,N,N,N-tributyl-,bromide;n,n,n-tributyl-1-butanaminiubromide;ALIQUAT(R) 100;IPC-TBA-BR;Tetrabutylazanium bromide;Tetrabutylaminium·bromide;Tetrabutylammonium bromide, 99%, for ion-pair chromatography CAS: 1643-19-2 MF: C16H36BrN MW: 322.37 EINECS: 216-699-2 Product Categories: organo amine halide;Other Products;Ammonium SaltsEssential Chemicals;Reagent Plus;Routine Reagents;Ammonium SaltsAnalytical Reagents;Electrochemistry;Supporting Electrolytes for Electrochemistry;AnionicHPLC;Chromatography/CE Reagents;Ion Pair;Ion Pair Reagents;Ion Pair Reagents - Anionic;Ion Pair Reagents - Anionic Concentrate;quarternary ammonium salts;Ammonium Bromides (Quaternary);Analytical Chemistry;HPLC Ion-Pair Reagents for Acidic Samples;Ion-Pair Reagents for HPLC;Quaternary Ammonium Compounds;Ammonium, Phosphonium, Sulfonium Salts (Ionic Liquids);Ionic Liquids;Synthetic Organic Chemistry;Ammonium Salts;Greener Alternatives: Catalysis;Phase Transfer Catalysts;Pharmaceutical intermediates;1643-19-2 Mol File: 1643-19-2.mol   Tetrabutylammonium bromide Chemical Properties Melting point  102-106 °C(lit.) Boiling point  102 °C density  1.039 g/mL at 25 °C refractive index  n20/D 1.422 Fp  100℃ storage temp.  Store below +30°C. solubility  H2O: 0.1 g/mL, clear, colorless form  Crystalline Powder color  White to slightly cream Specific Gravity 1.007 Odor Amine like Water Solubility  600 g/L (20 ºC) λmax λ: 240 nm Amax: 0.04 λ: 250 nm Amax: 0.03 λ: 260 nm Amax: 0.02 λ: 500 nm Amax: 0.02 Sensitive  Hygroscopic BRN  3570983 Stability: Stable. Incompatible with strong oxidizing agents. Protect from moisture. InChIKey JRMUNVKIHCOMHV-UHFFFAOYSA-M CAS DataBase Reference 1643-19-2(CAS DataBase Reference) NIST Chemistry Reference Tetra-N-butylammonium bromide(1643-19-2) EPA Substance Registry System Tetrabutylammonium bromide (1643-19-2)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-22 Safety Statements  26-36-37/39 WGK Germany  3 F  3 Hazard Note  Irritant TSCA  Yes HS Code  29239000 MSDS Information Provider Language Tetrabutylammonium bromide English ACROS English SigmaAldrich English ALFA English   Tetrabutylammonium bromide Usage And Synthesis Physical and Chemical Properties Tetrabutylammonium bromide, also known as tetrabutylammonium bromide. White crystal, deliquescence. 118 ℃ melting point. Soluble in water, alcohol, ether and acetone, slightly soluble in benzene. Figure 1:  a structural formula of tetrabutylammonium bromide Application (1) Used as a reagent for the analysis of organic synthesis. (2) Tetrabutylammonium bromide is also an effective phase transfer catalyst. Phase transfer catalyst, referred to as PTC, is able to transfer the aqueous phase (or organic phase) to the organic phase (or aqueous phase) catalyst, which can make the reaction between the aqueous phase and the organic phase of the catalyst. PTC has the function of changing the degree of ion solvation, increasing the activity of ion reaction, speeding up the reaction rate and so on. Solve the problem of the past in the two phases of the reaction is difficult to react. Common quaternary ammonium salt phase transfer catalysts are: benzyl triethyl ammonium chloride, trioctyl methyl ammonium chloride, tetramethyl ammonium bromide, tetrapropylammonium chloride, tetrabutylammonium bromide , tetrabutyl ammonium iodide, benzyl triethyl ammonium bromide, triethyl hexyl bromide, octyl triethylammonium bromide. Phase transfer catalyst is widely applied in organic synthesis: R2C for preparing compounds (carbene type compound), further preparation of the corresponding nitrile, isonitrile, Halon, dichloromethane cyclopropane derivatives, hydroxy acids and diazomethane. For the alkylation reaction, compared with traditional methods, to avoid the harsh conditions of dry operation, and high yield, it can also be used in the redox reaction, ester hydrolysis, substitution reaction, condensation reaction, addition reaction, polymerization reaction, addition reaction of carbon and the elimination of reaction and so on. (3) For organic synthesis intermediates, phase transfer catalyst (4) Ion-pairing reagents for the synthesis of bacampicillin, sultamicillin like. (5) Ion pair chromatography reagents, phase transfer catalyst. Bacampicillin, sultamicillin like synthesis. Uses Tetrabutylammonium bromide (TBAB) is a quaternary ammonium compound. It is the most widely used phase transfer catalyst. Its interfacial properties have been studied in case of hydroxide initiated reactions. This may be applied in understanding the mechanism of phase transfer reactions. TBAB is reported to decrease retention time and remove peak tailing by acting as an ion pair reagent during the chromatographic analysis of quaternary ammonium compounds. In the molten state TBAB behaves like an ionic liquid which is a promising green alternative to organic solvents in organic synthesis. Its molar heat capacity, entropy and free energy function have been determined. Recently, molten tetrabutylammonium bromide (TBAB) was used as a low toxic and cost-effective IL in a number of constructive synthetic transformations. Tetrabutylammonium bromide (TBAB) may be used in the molten state in the following processes: Synthesis of (2S)-5-(3-phenyl-2-phthalimidylpropanoylamino)isophthalic acid. Synthesis of alkyl-substituted pyrroles in the absence of catalyst and organic solvent. Synthesis of dithioacetals from acetals by transthioacetalisation in a solvent free environment. Synthesis of polyamides (PAs) by the polymerization of terephthalic acid and diisocyanates. Catalyze the addition of thiols to conjugated alkenes. Dehydrochlorination of poly(vinyl chloride). preparation Preparative Methods: several methods are available to recover the quaternary ammonium ion efficiently.Prepared by reaction of tri-n-butylamine and n-butyl bromide. Toxicity The acute oral LD50 (mouse): 590mg/kg. Inhalation, ingestion and skin contact toxic to the skin, eyes and respiratory system irritation. More information from the ChemicalBook Xiaonan editor (2015-09-16). Chemical Properties white crystals or powder Uses PTC catalyst Uses Tetrabutylammonium Bromide is used in the synthesis of polymer solar cells. Also used in the synthesis of single component green-light emitting electrochemical cells. Uses Tetrabutylammonium bromide may be used as a catalyst in the synthesis of following: 1-cyano-2-thiophenylethane 1-cyano-2-thiobutylethane 1-cyano-2-(2-aminothiophenyl)ethane methyl 3-thiophenylpropionate methyl 3-thiobutylpropionate methyl 2-methyl-3-thiophenylpropionate methyl 2-methyl-3-thiobutylpropionate diethyl 2-thiophenylsuccinate diethyl 2-thiobutylsuccinate 3-(4-chlorophenyl)-2-nitro-2-thiophenylpropane 4-(4-chlorophenyl)-3-nitro-4-thiobutylbutane 3-thiophenylcyclohexanone 3-thioethylcyclohexanone 4-methyl-4-thiophenylpentan-2-one 4-methyl-4-thiobutylpentan-2-one 4-thiophenylbutan-2-one 4-thiobutylbutan-2-one 3-thiophenylbutanal 3-thiobutylbutanal Definition ChEBI: A tetrabutylammonium salt with bromide as the anionic counterpart. General Description Tetrabutylammonium bromide, a quaternary ammonium compound widely used as a phase transfer catalyst. TBAB decreases the retention time and removes peak tailing by acting as an ion pair reagent during the chromatographic analysis of quaternary ammonium compounds. In the molten state, TBAB behaves like an ionic liquid, which is a promising green alternative to organic solvents in polymer synthesis. Purification Methods Crystallise the salt from *benzene (5mL/g) at 80o by adding hot n-hexane (three volumes) and allowing to cool. Dry it over P2O5 or Mg(ClO4)2, under vacuum. The salt is very hygroscopic. It can also be crystallised from ethyl acetate or dry acetone by adding diethyl ether and dried in vacuo at 60o for 2 days. It has been crystallised from acetone by addition of diethyl ether. It is so hygroscopic that all manipulations should be carried out in a dry-box. It has been purified by precipitation from a saturated solution in dry CCl4 on addition of cyclohexane or by recrystallisation from ethyl acetate, then heating in vacuum to 75o in the presence of P2O5. [Symons et al. J Chem Soc, Faraday Trans 1 76 2251 1908.] It also recrystallises from CH2Cl2/diethyl ether and is dried in a vacuum desiccator over P2O5. [Blau & Espenson J Am Chem Soc 108 1962 1986, Beilstein 4 IV 657.]   Tetrabutylammonium bromide Preparation Products And Raw materials Preparation Products 1-BENZOTHIOPHENE-5-CARBOXYLIC ACID-->Albendazole-->Piperonyl aldehyde-->3-AMINOBIPHENYL-->5-Bromoindazole-->ETHYL 4-ETHOXYPHENYLACETATE-->H-GLY-AMC HBR-->1-Phenylcyclopentanecarboxylic acid-->3-PHENYLBENZYLAMINE-->4-PYRIDIN-2-YLISOXAZOL-5-AMINE-->cintofen-->FENOTHIOCARB-->(R)-(-)-2,2-Dimethyl-1,3-dioxolane-4-methanol-->Isocarbophos-->Venlafaxine hydrochloride-->1-BENZOTHIOPHENE-5-CARBONITRILE-->N-(4-THIOPHEN-2-YL-PHENYL)-ACETAMIDE-->Thianaphthene-2-carboxylic acid-->Myclobutanil-->alpha-butyl-alpha-phenyl-1H-imidazole-1-propiononitrile-->5-Bromobenzo[c]thiophene-->Olaquindox-->Sisthsne-->2-[2-(DIPHENYLPHOSPHINO)ETHYL]PYRIDINE-->Glyceryl monostearate-->1-(3-Aminopropyl)piperidine-->Phenyl vinyl sulfone-->6-Bromopurine-->Methyl 3,4,5-trimethoxybenzoate-->CYCLANILIDE-->2-(4-ETHOXYPHENYL)-2-METHYL PROPIONITRILE-->Levetiracetam-->4-Bromo-7-azaindole-->DIOCTYL ETHER-->1,1-Cyclopropanedicarboxylic acid dimethyl ester-->2 -phenyl-Hexanenitrile-->Zeolite-->Tetrabutylammonium hexafluorophosphate-->4-(tert-Butyl)benzyl mercaptan-->Tetrabutylammonium borohydride

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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