China Largest Manufacturer factory sales Ginsenoside Rg3 CAS 38243-03-7

Superiority:

                                PRODUCT DETAILS                           

20(R)-Ginsenoside Rg3 Basic information Product Name: 20(R)-Ginsenoside Rg3 Synonyms: (2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methyl-hept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(10R,12S,13R,14R,17S)-12-hydroxy-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;GINSENOSIDE RG3(R-FORM)(P);Ginsenoside Rg3 (R-);Ginsenoside Rg3 Rh2;Ginseonoside Rg3;20(R)Ginsenoside Rg3 20(R);20(r)-propanaxadiol CAS: 38243-03-7 MF: C42H72O13 MW: 785.01 EINECS:   Product Categories: Ginsenoside series;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract Mol File: 38243-03-7.mol   20(R)-Ginsenoside Rg3 Chemical Properties Melting point  315-318 ºC Boiling point  885.0±65.0 °C(Predicted) density  1.30 storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere solubility  Chloroform (Very Slightly, Heated Sonicated), Pyridine (Slightly, Heated, Sonica pka 12.85±0.70(Predicted) form  Solid color  White to Off-White Stability: Hygroscopic   Safety Information MSDS Information   20(R)-Ginsenoside Rg3 Usage And Synthesis Description Ginsenoside Rg3 is mainly derived from the dried roots of Araliaceae Panax ginseng C.A. Mey. and Panax quinquefolius L. Ginseng has a long history of medicinal uses, well known as “king of herbs.” Ginseng is listed as the top grade in “Shen Nong’s herbal class,” with “the main security set up the five internal organs, spirit, soul, stop fright, in addition to evil, eyesight, fun puzzle” account. The traditional Chinese medicine regards ginseng as the top grade of reinforcing Qi, with Dabu strength, spleen and lungs, Sheng Jin, Anshen Yizhi, etc. Physical properties Appearance: white powder. Density: 1.40. Melting point: 315–318 °C. Solubility: 20(R)-ginsenoside Rg3 is soluble in methanol and ethanol; low water solubility; insoluble in ether and chloroform. Storage temperature: 2–8 °C. The component classification belongs to three dammarane tetracyclic triterpenoid saponins. History Ginseng is currently one of the most studied traditional medicines. Chemical researches certificate that ginseng contains a variety of ginseng saponin, ginseng polysaccharide, protein, polypeptide, amino acids, and other chemical constituents. Ginseng saponins are the main active components, accounting for about 4%. Ginsenoside is a kind of sterol compound, which has a similar basic structure. Ginsenoside contains the steroid nucleus of 17 carbon atoms arranged in 4 rings. At present, more than 40 kinds of ginsenosides have been isolated from ginseng. They are divided into four types according to their chemical structure, the protopanaxadiol, the protopanaxatriol, the ocotillol, and the oleanolic acid. Ginsenoside Rg3 is a dammarane tetracyclic triterpenoid saponin found in natural ginseng, which belongs to the protopanaxadiol . It is also the natural ingredient with prominent activity extracted from red ginseng (processed ginseng). Modern medicine has proved that Rg3 has certain biological activity. Since 1983, Rg3 has been widely studied by many scholars in the world . The results showed that the content of ginsenoside Rg3 in the fresh and dried ginseng roots was less than 1 ppm while in red ginseng was 3/100,000. After several years of research, the method of extracting 20(R)-ginsenoside Rg3 from red ginseng has been successfully improved, and the industrialized production has been realized. A multicenter clinical study by eight domestic hospitals indicated that 20(R)-ginsenoside Rg3 has therapeutic effects on tumor. It has been issued the new drug certificate by the Chinese Food and Drug Administration, as a new anticancer drug approved. Uses 20(R)-Ginsenoside Rg3 causes an inhibition of phosphatidylinositol 3-kinase/Akt activation that, in turn, results in modulations in Bcl-2 family proteins in such a way that the apoptosis of U87 cells are regulated. Elicits a significant inhibition of in vitro cell adhesion and invasion of U87 cells. in vitro stereoselective inhibition of ginsenosides toward UDP-glucuronosyltransferase isoforms and in vivo inhibition of tumor angiogenesis of lung cancer. Indications This product is contained in “New drug standards” the 87th volume. Ginsenoside Rg3 capsule, ginsenoside Rg3 emulsion, and ginsenoside Rg3 microemulsion are mainly used in the clinical treatment or adjuvant therapy of lung cancer, breast cancer, liver cancer, gastric cancer, colon cancer, etc. In addition, they improve and prevent the common diseases in the elderly such as cardiovascular disease, coronary heart disease, limb weakness, difficulty walking, and loss of memory. Ginsenoside Rg3 also has a certain biological activity in antiviral, radiosensitization, and treatment of chronic obstructive pulmonary disease. Pharmacology It is reported that the antitumor effects of ginsenoside Rg3 and Rh2 were the most significant in more than 40 kinds of ginsenosides obtained. Moreover, they enhanced the immune function of tumor patients after chemotherapy, including humoral immunity, cell immunity, and non-specific immunity . This effect is consistent with the vitality nourishing and body strengthening of ginseng in the theory of traditional Chinese medicine. There is more research on the effects of 20(R)-ginsenoside Rg3 in the two isomers of ginsenoside Rg3, which has certain inhibitory effects on tumor cells of lung cancer, gastric cancer, colon cancer, breast cancer, liver cancer, etc. There is less research on the effects of 20(S)-ginsenoside Rg3. Other studies have shown that ginsenoside Rg3 also has the effects of anti-fatigue , antiviral , and treatment of chronic obstructive pulmonary disease . Human tolerance test shows that ginsenoside Rg3 has a wide safety range. The recommended dose of the first phase of clinical trial (0.8 mg/kg/day) has no side effects. Ginsenoside Rg3 has good oral absorption. The drug absorption peak in the blood is detected after administration for 15–30 min, and the blood concentration reaches the peak after administration for 1.0–1.5 h. The half-life is 4.84±1.41 h. The maximum blood concentration increases with the dose within the reagent range (0.8–3.2 mg/kd/day), suggesting the pharmacokinetics of ginsenoside Rg3 the firstorder kinetics process. Clinical Use The basic research for many years and a large number of clinical data confirm that ginsenoside Rg3 effectively inhibits the growth of lung cancer, liver cancer, gastric cancer, colon cancer, and breast cancer, significantly improves the clinical symptoms of patients, improves the quality of life, and prevents and treats cancer. Ginsenoside Rg3 effectively improves the ability of anti-fatigue, antiaging, and resistance to disease. It also improves cardiovascular function, is resistant to platelet aggregation, protects nerve cells of brain, and improves immunity. Ginsenoside Rg3 is the active ingredient of Shenyi capsule which is a kind of traditional Chinese anticancer medicine developed in China. It prevents the metastasis and recurrence of cancer and has been an adjuvant treatment in multiple tumors . Shenyi capsule improves the curative effects of primary lung cancer and liver cancer, relieves the symptoms of Qi deficiency, as well as improves immunity, when combined with chemotherapy. Further study on the antitumor mechanism of ginsenoside Rg3 will be helpful to the clinical application of this drug.   20(R)-Ginsenoside Rg3 Preparation Products And Raw materials Preparation Products Protopanaxadiol

                                                                       Group profiles

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse