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China Largest Manufacturer factory sales Butylated hydroxyanisole（BHA） CAS 25013-16-5
China Largest Manufacturer factory sales Butylated hydroxyanisole（BHA） CAS 25013-16-5
China Largest Manufacturer factory sales Butylated hydroxyanisole（BHA） CAS 25013-16-5
China Largest Manufacturer factory sales Butylated hydroxyanisole（BHA） CAS 25013-16-5
China Largest Manufacturer factory sales Butylated hydroxyanisole（BHA） CAS 25013-16-5

China Largest Manufacturer factory sales Butylated hydroxyanisole（BHA） CAS 25013-16-5

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500 Kilogram

FOB Price:USD 1.0000 -2.0000
  • Min.Order :500 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Butylated hydroxyanisole Butylated hydroxyanisole 25013-16-5

Quick Details

  • Appearance:white powder
  • Application:Pharm chemicals industry
  • PackAge:25KG/Drum
  • ProductionCapacity:20|Metric Ton|Month
  • Storage:2-8°C
  • Transportation:By air /Sea/ coruier

Superiority:

                                PRODUCT DETAILS       

Butylated hydroxyanisole Basic information
Product Name: Butylated hydroxyanisole
Synonyms: Butylated hydroxyanisoleBHA2(3)-tert-Butyl-4-methoxyphenol3(2)-tert-Butyl-4-hydroxyanisole;butylhydroxyanisole standard(mixture of isomers);2(3)-t-Butylhydroquinone monomethyl ether BHA;Butylated hydroxyanisole ,98.5%;tert-Butyl-4-hydroxyanisole (mixture of 2- and 3-isomer);Butylated hydroxyanisole 1g [25013-16-5];Butylated hydroxyanisole,2(3)-t-Butyl-4-hydroxyanisole, 2(3)-t-Butylhydroquinone monomethyl ether, BHA;tert-BUTYLHYDROXYANISOLE TECH
CAS: 25013-16-5
MF: C11H16O2
MW: 180.24354
EINECS: 246-563-8
Product Categories: Cnbio;Multidrug Resistance;Phase II Enzyme Inducers;Building Blocks;C9 to C20+;Cancer Research;Chemical Synthesis;Chemopreventive Agents;Organic Building Blocks;Oxygen Compounds;Phenols;VX:15689727968;3
Mol File: 25013-16-5.mol
Butylated hydroxyanisole Structure
 
Butylated hydroxyanisole Chemical Properties
Melting point  58-60 °C(lit.)
Boiling point  264-270°C
density  0.9976 (rough estimate)
vapor density  6.2 (vs air)
refractive index  1.4910 (estimate)
FEMA  2183 | BUTYLATED HYDROXYANISOLE
Fp  >230 °F
storage temp.  2-8°C
solubility  Practically insoluble in water; soluble in methanol; freely soluble in ≥50% aqueous ethanol, propylene glycol, chloroform, ether, hexane, cottonseed oil, peanut oil, soybean oil, glyceryl monooleate, and lard, and in solutions of alkali hydroxides.
form  Crystalline Flakes or Crystals
color  White to pale yellow
Water Solubility  <0.1 g/100 mL at 18.5 ºC
Merck  14,1547
Stability: Stable, combustible. Incompatible with oxidizing agents, ferric salts. Degrades on long exposure to sunlight.
InChIKey WYEIRNDSZQKIDQ-UHFFFAOYSA-N
IARC 2B (Vol. 40, Sup 7) 1987
EPA Substance Registry System Butylated hydroxyanisole (25013-16-5)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-40-36/37/38-51/53
Safety Statements  36/37-36/37/39-26-61-29
RIDADR  2811
WGK Germany  2
RTECS  SL1945000
Autoignition Temperature 599 °F
TSCA  Yes
HS Code  29093090
Hazardous Substances Data 25013-16-5(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 2000, 2200 orally (Lehman)
MSDS Information
Provider Language
3(2)-tert-Butyl-4-hydroxyanisole English
ACROS English
SigmaAldrich English
ALFA English
 
Butylated hydroxyanisole Usage And Synthesis
Description Butylated hydroxyanisole (BHA) is an antioxidant widely used in food. Because it is contained in pastry, it can induce sensitization in caterers.
Chemical Properties BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. Chemically, BHA is a mixture of two isomers, 3-tertiary-butyl-4-hydroxyanisole (90%) and 2-tertiary-butyl-4-hydroxyanisole (10%). Both BHA and BHT assert a good carry-through effect, although BHA is slightly better than BHT in this respect. BHT is, however, more effective in suppressing oxidation of animal fats than vegetable oils. Among its multiple applications, BHA is particularly useful in protecting the flavors and color of essential oils and is considered the most effective of all food-approved antioxidants for this application. BHA is particularly effective in controlling the oxidation of short-chain fatty acids, such as those found in coconut and palm kernel oils that are used typically in cereal and confectionary products.
Chemical Properties white or light yellow waxy solid with an
Chemical Properties Log Kow 5. 3. Values above 3.0 are likely to bioaccumulate in aquatic organisms
Chemical Properties Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.
Occurrence BHA is not known to occur as a natural product.
Uses BHA (butylated hydroxy anisole) is a preservative with anti-oxidant capabilities, not to be confused with beta hydroxy acids (BHAs).
Uses Butylated Hydroxyanisole (BHA) is an antioxidant that imparts stability to fats and oils and should be added before oxidation has started. It is a mixture of 3-tert-butyl-4-hydroxyanisole and 2-tertbutyl-4-hydroxyanisole. In direct addition, the fat or oil is heated to 60–70°C and the BHA is added slowly under vigorous agitation. The maximum concentration is 0.02% based on the weight of the fat or oil. It may protect the fat-soluble vitamins A, D, and E. It is used singly or in combination with other antioxidants. It is used in cereals, edible fat, vegetable oil, confectionary products, and rice.
Uses Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.
Uses Antioxidant and preservative, especially in foods, cosmetics, pharmaceuticals; also rubber and petroleum products.
Definition A mixture of 2- and 3-tert-4-methoxyphenol.
Production Methods Prepared by the reaction of p-methoxyphenol with isobutene.
Aroma threshold values Detection: 3 ppm
General Description White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.
Air & Water Reactions Insoluble in water.
Reactivity Profile Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.
Hazard Toxic by ingestion. Use in foods restricted; consult FDA regulations.
Fire Hazard Butylated hydroxyanisole is combustible.
Pharmaceutical Applications Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
Japanese regulations allow up to 1 g/kg in animal fats.
Contact allergens BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.
Safety Profile Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes
Safety Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
LD50 (mouse, oral): 1.1–2.0 g/kg
LD50 (rabbit, oral): 2.1 g/kg
LD50 (rat, IP): 0.88 g/kg
LD50 (rat, oral): 2.0 g/kg
Chemical Synthesis Several methods are used for the commercial production of BHA. Methylation of hydroquinone yields an intermediate that gives a mixture of 3-BHA and 2-BHA upon treatment with tert-butyl alcohol and phosphoric acid. Butylation of hydroquinone and subsequent methylation with dimethyl sulfate and sodium hydroxide can also be used to produce a mixture of the two BHA isomers. In addition BHA can be synthesized by the tert-butylation of 4-methoxyphenol over silica or alumina at 150°C.
Carcinogenicity Butylated hydroxyanisole (BHA) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate The metabolites of BHA can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.
storage Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.
Shipping UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required
Toxicity evaluation BHA is a white or slightly yellow, waxy solid with a characteristic odor. It is insoluble in water, but soluble in fats, oils, and solvents like petroleum ether, chloroform, and alcohol. Its octanol/water partition coefficient is 3.50; vapor pressure is 2.48×10-3 mm Hg at 25°C; and Henry’s law constant is 1.17×10-6 atm-m3 mol-1.
BHA is released into the environment through waste streams. It has low soil mobility and volatilizes slowly from water. It may bioconcentrate in aquatic organisms, adsorb to sediment, and be subject to direct photolysis.
Incompatibilities Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.
Waste Disposal Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.
Regulatory Status GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
 
Butylated hydroxyanisole Preparation Products And Raw materials
Raw materials Sodium nitrite-->Benzene-->Dimethyl sulfate-->ZINC-->Phosphoric acid-->tert-Butanol-->Hydroquinone-->p-Anisidine-->4-Methoxyphenol-->tert-Butylhydroquinone

                   


Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Butylated hydroxyanisole Basic information
Product Name: Butylated hydroxyanisole
Synonyms: Butylated hydroxyanisoleBHA2(3)-tert-Butyl-4-methoxyphenol3(2)-tert-Butyl-4-hydroxyanisole;butylhydroxyanisole standard(mixture of isomers);2(3)-t-Butylhydroquinone monomethyl ether BHA;Butylated hydroxyanisole ,98.5%;tert-Butyl-4-hydroxyanisole (mixture of 2- and 3-isomer);Butylated hydroxyanisole 1g [25013-16-5];Butylated hydroxyanisole,2(3)-t-Butyl-4-hydroxyanisole, 2(3)-t-Butylhydroquinone monomethyl ether, BHA;tert-BUTYLHYDROXYANISOLE TECH
CAS: 25013-16-5
MF: C11H16O2
MW: 180.24354
EINECS: 246-563-8
Product Categories: Cnbio;Multidrug Resistance;Phase II Enzyme Inducers;Building Blocks;C9 to C20+;Cancer Research;Chemical Synthesis;Chemopreventive Agents;Organic Building Blocks;Oxygen Compounds;Phenols;VX:15689727968;3
Mol File: 25013-16-5.mol
Butylated hydroxyanisole Structure
 
Butylated hydroxyanisole Chemical Properties
Melting point  58-60 °C(lit.)
Boiling point  264-270°C
density  0.9976 (rough estimate)
vapor density  6.2 (vs air)
refractive index  1.4910 (estimate)
FEMA  2183 | BUTYLATED HYDROXYANISOLE
Fp  >230 °F
storage temp.  2-8°C
solubility  Practically insoluble in water; soluble in methanol; freely soluble in ≥50% aqueous ethanol, propylene glycol, chloroform, ether, hexane, cottonseed oil, peanut oil, soybean oil, glyceryl monooleate, and lard, and in solutions of alkali hydroxides.
form  Crystalline Flakes or Crystals
color  White to pale yellow
Water Solubility  <0.1 g/100 mL at 18.5 ºC
Merck  14,1547
Stability: Stable, combustible. Incompatible with oxidizing agents, ferric salts. Degrades on long exposure to sunlight.
InChIKey WYEIRNDSZQKIDQ-UHFFFAOYSA-N
IARC 2B (Vol. 40, Sup 7) 1987
EPA Substance Registry System Butylated hydroxyanisole (25013-16-5)
 
Safety Information
Hazard Codes  Xn
Risk Statements  22-40-36/37/38-51/53
Safety Statements  36/37-36/37/39-26-61-29
RIDADR  2811
WGK Germany  2
RTECS  SL1945000
Autoignition Temperature 599 °F
TSCA  Yes
HS Code  29093090
Hazardous Substances Data 25013-16-5(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 2000, 2200 orally (Lehman)
MSDS Information
Provider Language
3(2)-tert-Butyl-4-hydroxyanisole English
ACROS English
SigmaAldrich English
ALFA English
 
Butylated hydroxyanisole Usage And Synthesis
Description Butylated hydroxyanisole (BHA) is an antioxidant widely used in food. Because it is contained in pastry, it can induce sensitization in caterers.
Chemical Properties BHA and BHT (butylated hydroxytoluene) are monohydric phenolic antioxidants that, prior to their introduction and acceptance in the food industry, were used to protect petroleum against oxidative degumming. Chemically, BHA is a mixture of two isomers, 3-tertiary-butyl-4-hydroxyanisole (90%) and 2-tertiary-butyl-4-hydroxyanisole (10%). Both BHA and BHT assert a good carry-through effect, although BHA is slightly better than BHT in this respect. BHT is, however, more effective in suppressing oxidation of animal fats than vegetable oils. Among its multiple applications, BHA is particularly useful in protecting the flavors and color of essential oils and is considered the most effective of all food-approved antioxidants for this application. BHA is particularly effective in controlling the oxidation of short-chain fatty acids, such as those found in coconut and palm kernel oils that are used typically in cereal and confectionary products.
Chemical Properties white or light yellow waxy solid with an
Chemical Properties Log Kow 5. 3. Values above 3.0 are likely to bioaccumulate in aquatic organisms
Chemical Properties Butylated hydroxyanisole occurs as a white or almost white crystalline powder or a yellowish-white waxy solid with a faint, characteristic aromatic odor.
Occurrence BHA is not known to occur as a natural product.
Uses BHA (butylated hydroxy anisole) is a preservative with anti-oxidant capabilities, not to be confused with beta hydroxy acids (BHAs).
Uses Butylated Hydroxyanisole (BHA) is an antioxidant that imparts stability to fats and oils and should be added before oxidation has started. It is a mixture of 3-tert-butyl-4-hydroxyanisole and 2-tertbutyl-4-hydroxyanisole. In direct addition, the fat or oil is heated to 60–70°C and the BHA is added slowly under vigorous agitation. The maximum concentration is 0.02% based on the weight of the fat or oil. It may protect the fat-soluble vitamins A, D, and E. It is used singly or in combination with other antioxidants. It is used in cereals, edible fat, vegetable oil, confectionary products, and rice.
Uses Butylated Hydroxyanisole is an antioxidant consisting of a mixture of two isomers of tert-butyl-4-hydroxyanisole. Butylated Hydroxyanisole is used in food preservation as it antioxidant properties pre vent food from becoming rancid. Butylated Hydroxyanisoleas is also used in animal feed, petroleum products, and cosmetics.
Uses Antioxidant and preservative, especially in foods, cosmetics, pharmaceuticals; also rubber and petroleum products.
Definition A mixture of 2- and 3-tert-4-methoxyphenol.
Production Methods Prepared by the reaction of p-methoxyphenol with isobutene.
Aroma threshold values Detection: 3 ppm
General Description White, beige or slightly yellow waxy solid with an aromatic odor and a slightly bitter burning taste.
Air & Water Reactions Insoluble in water.
Reactivity Profile Butylated hydroxyanisole degrades with prolonged exposure to sunlight. Exhibits antioxidant properties and synergism with acids, BHT, propyl gallate, hydroquinone, methionine, lecithin and thiodipropionic acid. Butylated hydroxyanisole exhibits antioxidant properties as a scavenger of free radicals. Butylated hydroxyanisole is incompatible with oxidizing agents and ferric salts.
Hazard Toxic by ingestion. Use in foods restricted; consult FDA regulations.
Fire Hazard Butylated hydroxyanisole is combustible.
Pharmaceutical Applications Butylated hydroxyanisole is an antioxidant with some antimicrobial properties. It is used in a wide range of cosmetics, foods, and pharmaceuticals. When used in foods, it is used to delay or prevent oxidative rancidity of fats and oils and to prevent loss of activity of oil-soluble vitamins.
Butylated hydroxyanisole is frequently used in combination with other antioxidants, particularly butylated hydroxytoluene and alkyl gallates, and with sequestrants or synergists such as citric acid.
FDA regulations direct that the total content of antioxidant in vegetable oils and direct food additives shall not exceed 0.02% w/w (200 ppm) of fat or oil content or essential (volatile) oil content of food.
USDA regulations require that the total content of antioxidant shall not exceed 0.01% w/w (100 ppm) of any one antioxidant or 0.02% w/w combined total of any antioxidant combination in animal fats.
Japanese regulations allow up to 1 g/kg in animal fats.
Contact allergens BHA is an antioxidant widely used in cosmetics and food. Contained in pastry, it can induce sensitization in caterers.
Safety Profile Confirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data. Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid and irritating fumes
Safety Butylated hydroxyanisole is absorbed from the gastrointestinal tract and is metabolized and excreted in the urine with less than 1% unchanged within 24 hours of ingestion. Although there have been some isolated reports of adverse skin reactions to butylated hydroxyanisole, it is generally regarded as nonirritant and nonsensitizing at the levels employed as an antioxidant.
Concern over the use of butylated hydroxyanisole has occurred following long-term animal feeding studies. Although previous studies in rats and mice fed butylated hydroxyanisole at several hundred times the US-permitted level in the human diet showed no adverse effects, a study in which rats, hamsters, and mice were fed butylated hydroxyanisole at 1–2% of the diet produced benign and malignant tumors of the forestomach, but in no other sites. However, humans do not have any region of the stomach comparable to the rodent forestomach and studies in animals that also do not have a comparable organ (dogs, monkeys, and guinea pigs) showed no adverse effects. Thus, the weight of evidence does not support any relevance to the human diet where butylated hydroxyanisole is ingested at much lower levels. The WHO acceptable daily intake of butylated hydroxyanisole has been set at 500 μg/kg body-weight.
LD50 (mouse, oral): 1.1–2.0 g/kg
LD50 (rabbit, oral): 2.1 g/kg
LD50 (rat, IP): 0.88 g/kg
LD50 (rat, oral): 2.0 g/kg
Chemical Synthesis Several methods are used for the commercial production of BHA. Methylation of hydroquinone yields an intermediate that gives a mixture of 3-BHA and 2-BHA upon treatment with tert-butyl alcohol and phosphoric acid. Butylation of hydroquinone and subsequent methylation with dimethyl sulfate and sodium hydroxide can also be used to produce a mixture of the two BHA isomers. In addition BHA can be synthesized by the tert-butylation of 4-methoxyphenol over silica or alumina at 150°C.
Carcinogenicity Butylated hydroxyanisole (BHA) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate The metabolites of BHA can bind to cellular macromolecules, such as proteins and DNA, and cause toxicity.
storage Exposure to light causes discoloration and loss of activity. Butylated hydroxyanisole should be stored in a well-closed container, protected from light, in a cool, dry place.
Shipping UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1—Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9— Miscellaneous hazardous material, Technical Name Required
Toxicity evaluation BHA is a white or slightly yellow, waxy solid with a characteristic odor. It is insoluble in water, but soluble in fats, oils, and solvents like petroleum ether, chloroform, and alcohol. Its octanol/water partition coefficient is 3.50; vapor pressure is 2.48×10-3 mm Hg at 25°C; and Henry’s law constant is 1.17×10-6 atm-m3 mol-1.
BHA is released into the environment through waste streams. It has low soil mobility and volatilizes slowly from water. It may bioconcentrate in aquatic organisms, adsorb to sediment, and be subject to direct photolysis.
Incompatibilities Butylated hydroxyanisole is phenolic and undergoes reactions characteristic of phenols. It is incompatible with oxidizing agents and ferric salts. Trace quantities of metals and exposure to light cause discoloration and loss of activity.
Waste Disposal Suggested: Dispose of contents and container to an approved waste disposal plant. All federal, state, and local environmental regulations must be observed.
Regulatory Status GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (IM and IV injections, nasal sprays, oral capsules and tablets, and sublingual, rectal, topical, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
 
Butylated hydroxyanisole Preparation Products And Raw materials
Raw materials Sodium nitrite-->Benzene-->Dimethyl sulfate-->ZINC-->Phosphoric acid-->tert-Butanol-->Hydroquinone-->p-Anisidine-->4-Methoxyphenol-->tert-Butylhydroquinone
 

 

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