China Largest Manufacturer factory sales 3-Cyanopyridine CAS 100-54-9

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3-Cyanopyridine Basic information Product Name: 3-Cyanopyridine Synonyms: NICOTINIC ACID NITRILE;NICOTINONITRILE;NICOTINE ACID NITRILE;SPECS AC-907/25014098;TIMTEC-BB SBB007554;IFLAB-BB F2108-0102;BETA-CYANOPYRIDINE;3-Azabenzonitrile CAS: 100-54-9 MF: C6H4N2 MW: 104.11 EINECS: 202-863-0 Product Categories: Pharmaceutical intermediates;Pyridines derivates;Heterocyclic Compounds Mol File: 100-54-9.mol   3-Cyanopyridine Chemical Properties Melting point  48-52 °C(lit.) Boiling point  201 °C(lit.) density  1.159 refractive index  1.5242 (estimate) Fp  184 °F storage temp.  Inert atmosphere,Room Temperature solubility  140g/l pka pK1:1.45(+1) (25°C) form  Crystalline Mass, Crystals or Chunks color  Colorless or white to yellow Water Solubility  140 g/L (20 ºC) BRN  107711 Stability: Incompatible with strong oxidizing agents, strong reducing agents, strong acids, strong bases. InChIKey GZPHSAQLYPIAIN-UHFFFAOYSA-N CAS DataBase Reference 100-54-9(CAS DataBase Reference) NIST Chemistry Reference 3-Pyridinecarbonitrile(100-54-9) EPA Substance Registry System 3-Pyridinecarbonitrile (100-54-9)   Safety Information Hazard Codes  Xn Risk Statements  22-36/37/38 Safety Statements  22-24/25-36/37/39-26 WGK Germany  3 RTECS  QT3030000 TSCA  Yes HS Code  29333999 Hazardous Substances Data 100-54-9(Hazardous Substances Data) MSDS Information Provider Language 3-Cyanopyridine English SigmaAldrich English ACROS English ALFA English   3-Cyanopyridine Usage And Synthesis Chemical Properties white to beige solid Chemical Properties The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid. Uses 3-Cyanopyridine is used in the preparation of arylthiazolines and arylimidazolines via dibromodimethylhydantoin-catalyzed condensation of aryl nitriles with ethylene diamine or aminoethanethiol. Definition ChEBI: A nitrile that is pyridine substituted by a cyano group at position 3. Synthesis Reference(s) Tetrahedron Letters, 29, p. 2155, 1988 DOI: 10.1016/S0040-4039(00)86697-6 Potential Exposure Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period. Shipping UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5). Purification Methods It is recrystallised to constant melting point from o-xylene/hexane. [Beilstein 22/2 V 115.] Incompatibilities Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .   3-Cyanopyridine Preparation Products And Raw materials Raw materials 4-Chlorobenzaldehyde-->Nicotinamide-->N-PHENYL-1-NAPHTHYLAMINE HYDROBROMIDE, 98 Preparation Products Nicotinic acid-->Nicotinamide-->3-(AMINOMETHYL)PYRIDINE-->2-(3-PYRIDYL)-1,3-THIAZOLE-4-CARBOXYLIC ACID-->2-chloro-5-cyanopyridine-->3-Pyridinecarboxaldehyde-->2-(2-PYRIDINYL)-4-(TRIFLUOROMETHYL)-5-PYRIMIDINECARBOXYLIC ACID-->3-AMINOMETHYL-PYRIDINE-2-CARBOXYLIC ACID-->3-AMIDINOPYRIDINIUM CHLORIDE-->ETHYL 4-(TRIFLUOROMETHYL)-2-(PYRIDIN-2-YL)PYRIMIDINE-5-CARBOXYLATE-->3-(TERT-BUTOXYCARBONYLAMINO-METHYL)-PYRIDINE-2-CARBOXYLIC ACID-->3,3'-DIPICOLYLAMINE-->3-PYRIDINECARBOXAMIDINE-->3-CYANOPYRIDIN-4-YLBORONIC ACID-->3-[(N-(TERT-BUTYLOXYCARBONYL)AMINO)METHYL]PYRIDINE-->3-(Aminomethyl)pyridine-->3-PYRIDYLAMIDOXIME-->Methyl 2-(3-cyanopyridin-4-yl)acetate-->3-Pyridinemethanol-->Benzyltriphenylphosphonium chloride

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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