China Largest Manufacturer factory sales Bengenin CAS 477-90-7

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Bengenin Basic information Product Name: Bengenin Synonyms: Pimpinollin;Ai Cha Su;Ardisic acid B;Bergenin (6CI, 8CI);NSC 661749;Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-;Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, [2R-(2α,3β,4α,4aα,10bβ)]-;α-Resorcylic acid, 4-methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-, δ-lactone (7CI) CAS: 477-90-7 MF: C14H16O9 MW: 328.27 EINECS: 803-760-9 Product Categories: Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Heterocycles;Natural Plant Extract;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;Plant extracts;Inhibitors Mol File: 477-90-7.mol   Bengenin Chemical Properties Melting point  237-240 °C(lit.) alpha  D18 -37.7° (c = 1.96 in ethanol); D24 -45.3° (c = 0.51 for anhydr in water) Boiling point  386.03°C (rough estimate) density  1.3901 (rough estimate) refractive index  1.6550 (estimate) storage temp.  -20°C solubility  DMSO (Slightly), Methanol (Slightly) pka 8.26±0.70(Predicted) form  neat color  White to Off-White λmax 277nm(EtOH)(lit.) CAS DataBase Reference 477-90-7(CAS DataBase Reference)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36/37/38-20/21/22 Safety Statements  26-36 WGK Germany  3 RTECS  UQ0337200 HS Code  29329990 MSDS Information   Bengenin Usage And Synthesis Description The plant resources of bergenin are rich, mainly from Rock cabbage (Bergenia purpurascens) and thick leafy rock cabbage (Astilbe macroflora) from Saxifragaceae and the roots, stems, and leaves of bai liang jin (Ardisia crispa) from Ardisia japonica (Thunb.) Blume. In Chinese medicine Rock cabbage (Bergenia purpurascens) is the common folk medicine, with nourishing, stanching bleeding, relieving a cough, and other effects. Its earliest record is contained in the classified herbal in Qing Dynasty . There are ten kinds of Rock cabbage (Bergenia purpurascens) in Asia, mainly growing in East Asia, north of South Asia, and southeastern Central Asia. There are seven species (including three endemic species) in China, mainly distributed in Shaanxi (Qinling), Xinjiang, Sichuan, Yunnan, and Tibet . Chemical Properties White powder Physical properties Appearance: white, loose needle-like crystal or crystalline powder with light odor and bitter taste and discolored when encountered with light or heat. Solubility: dissolved in methanol and slightly soluble in water or ethanol. Melting point: 232– 240 °C. Specific optical rotation: 38° to 45°. History In 1958, Hay and Haynes first reported the complete synthesis of bergenin, using 4-methoxy gallate and A-D-bromo-2, 3, 4, 6-tetraacetylglucose as raw materials to synthesize bergenin successfully . In 1987, Chen Wendou determined the content of bergenin as 5.8% in the alcohol extract of Astilbe chinensis (Maxim.), Franch. et Savat.(Luoxinfu), and Rock cabbage (Bergenia purpurascens) by using high-performance liquid chromatography. In 1991, Wang Junping determined the content of bergenin in the alcohol extract of Rodgersia podophylla as 19.17% with spectrophotometry. By doing thin layer qualitative analysis, Liu Nunian discovered that bergenin could be found in seven kinds of plants including sour moss (Ardisia solanacea), Luosan tree (Ardisia quinquegona Bl.), Cinnabar root (Ardisia crenata Sims), Zijinniu (Ardisia japonica), Lianzuozijinniu (Ardisia primulaefolia), Jiujielong (Ardisia pusilla), and Xinyezijinniu (Ardisia maclurei) from Ardisia. In addition, Zhang Yi determined the content of bergenin in the medicinal plants from Ardisiawith high-performance liquid chromatography, and results showed that there were four species of plants with the content of bergenin of more than 1%, having great resource utilization value. There are 11 species of plants with the content of bergenin less than 1%, such as Xiaoqiaomuzijinniu (Ardisia arborescens), twist fruit, fine umbrella (Ardisia affinis Hemsl.), and so on. They had some useful value as well . In recent years, it has been found that both 8, 10-dimethylca bergenin and 11-0-gallate betaine had weak inhibitory effects on the tumor in mice, and their effects were stronger than that of bergenin. The effect of acetylated bergenin was stronger than that of bergenin on liver injury induced by chloroform in mice. The new bergenin derivatives from the Ardisia gigantifolia stapf had a certain degree of free radical-scavenging effect and anti-HIV viral activity . Uses A herbal remedy with antioxidant, antimicrobial and antiinflammatory properties. Definition ChEBI: A natural product found in Cenostigma gardnerianum. General Description This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG Biochem/physiol Actions Bergenin displays antinociceptive and anti-inflammatory properties, in addition to its use in folk medicines as a potent hepatoprotective agent. Bergenin acts by inhibiting the formation of interleukin 1beta and TNF-α, which suggests its potential use for controling inflammatory pain. Pharmacology 1. Cough-relieving effect Bergenin had a significant relieving effect on coughs caused by electrical stimulation of the laryngeal nerve and ammonia spray. The dose of its cough-relieving effect was equivalent to 1/7–1/4 dose of codeine. No tolerance was found after a 23-day consecutive administration of bergenin due to its selective inhibition on cough center . 2. Expectorant effect Dwarf tea (Japanese Ardisia Herb) decoction was found to have a clear expectorant effect after intragastric administration to mice at the dose of 25 g/kg, and its effect strength is equivalent to that of Platycodon grandiflorum at the same dose. 3. Anti-inflammatory and anti-ulcer effect In the model of chronic bronchitis caused by sulfur dioxide fumigation in rats, 80 mg/kg/day of bergenin was given once a day for 10 days. The results showed that the tracheal goblet cell number from the rats in the treatment group decreased, suggesting that the amount of sputum reduced. Inflammatory cell infiltration was found to alleviate, and the degree of emphysema and lung collapse were also reduced. Okada found that bergenin had a therapeutic effect on experimental gastric ulcer rats, consistent with the clinical application of bergenin in the treatment of gastric ulcer, duodenal ulcer, and chronic gastritis . Recent studies have shown that bergenin had certain analgesic and antiinflammatory properties and had the potential to control inflammatory pain through inhibiting the production of IL-β and TNF-α . Bergenin preparations have been widely used clinically for the treatment of chronic bronchitis, gastritis, and gastric and duodenal ulcers. 4. Antipyretic effect The alcohol extracts of Ardisia crispa had a strong antipyretic effect on the fever caused by the injection of cholera typhoid, paratyphoid, TAB vaccine, and tetanus toxin in the ear of rabbit. 5. Antiviral effect Rodgersia podophylla alcohol extract at the dose of 0.017–0.034 mg/ml cannot only inhibit the replication of DNA virus but also the replication of RNA virus. The cells with inactivated virus can continue to split and proliferate, indicating that the treatment is effective and with no obvious cell toxicity . 6. Liver protection Bergenin was found to improve the liver injury induced by carbon tetrachloride in mice. It cannot only reduce the release of glutamate acetyltransferase and sorbitol dehydrogenase from mice liver but also reduce the glutathione reductase and increase the glutathione content, indicating that bergenin protected the liver through the regulation of glutathione and inhibiting the release of free radicals . 7. Cardiovascular system effects Bergenin had some therapeutic effects on the arrhythmia in mice. 8. Toxicity test Mice were intraperitoneally injected with bergenin; the minimum lethal dose is 10 g/kg; no toxic reaction was found after intragastric administration of bergenin at the dose of 12 g/kg. No effects were found in the growth and development, liver function, and ECG of young rats after the intragastric administration with bergenin at the dose of 2.5 g/kg for consecutive 60 days, and no toxic performance was found in the heart, liver, kidney, lung, spleen, stomach, intestine, brain, and other organs by pathological biopsy Clinical Use Bergenin was recorded in People’s Republic of China Pharmacopoeia as an antitussive expectorant, used for the treatment of chronic bronchitis, emphysema, bronchial asthma, and other respiratory diseases. Used alone, or in compound preparation, such as compound bergenin tablets, Qingjin syrup, Compound Hu ear tablets, Qingfei antitussive syrup, liver poison net particles, Kechuanping oral solution, and silicone lung oral solution, it is mainly used for the treatment of chronic bronchitis. Its efficacy was proven to be relatively stable and improved in the compound preparations after a wide range of clinical validation.   Bengenin Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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