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Sodium benzoate Basic information description Chemical properties Uses Content Analysis Toxicity Production methods Product Name: Sodium benzoate Synonyms: SODIUM BENZOATE;PUROX S;femanumber3025;sobenate;sodiumbenzoate,medicinal;sodiumbenzoicacid;ucephan;BENZOTRON(R) CAS: 532-32-1 MF: C7H5NaO2 MW: 144.10317 EINECS: 208-534-8 Product Categories: Food & Feed ADDITIVES;Food and Feed Additive;FOOD ADDITIVES;Food & Flavor Additives;Building Blocks;Fine chemicals;Carbonyl Compounds;Carboxylic Acid Salts;Chemical Synthesis;Organic Building Blocks;Food additive Mol File: 532-32-1.mol   Sodium benzoate Chemical Properties Melting point  >300 °C (lit.) density  1,44 g/cm3 FEMA  3025 | SODIUM BENZOATE Fp  >100°C storage temp.  room temp solubility  H2O: 1 M at 20 °C, clear, colorless form  Crystals, Granules, Flakes or Crystalline Powder color  White PH 7.0-8.5 (25℃, 1M in H2O) Water Solubility  soluble Merck  14,8582 BRN  3572467 Stability: Stable, but may be moisture senstive. Incompatible with strong oxidizing agents, alkalis, mineral acids. InChIKey WXMKPNITSTVMEF-UHFFFAOYSA-M CAS DataBase Reference 532-32-1(CAS DataBase Reference) NIST Chemistry Reference Sodium benzoate(532-32-1) EPA Substance Registry System Sodium benzoate (532-32-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38-62-63-68-36 Safety Statements  24/25-36-26 WGK Germany  1 RTECS  DH6650000 TSCA  Yes HS Code  29163100 Hazardous Substances Data 532-32-1(Hazardous Substances Data) Toxicity LD50 orally in rats: 4.07 g/kg (Smyth, Carpenter) MSDS Information Provider Language Sodium benzoate English SigmaAldrich English ACROS English ALFA English   Sodium benzoate Usage And Synthesis description Sodium benzoate, also known as benzoic acid sodium, is commonly used as food preservatives in food industry, odorless or with slight smell of benzoin, and tastes sweet astringency. Stable in air, can absorb moisture in open air. It’s naturally found in blueberry, apple, plum, cranberry, prunes, cinnamon and cloves, with weaker antiseptic performance than benzoic acid. Antiseptic performance of 1.180g sodium benzoate is equivalent of about 1g benzoic acid. In acidic environment, sodium benzoate have obvious inhibitory effect on a variety of microorganisms: when pH is at 3.5, 0.05% solution can completely inhibit the growth of yeast; while when pH is above 5.5, it has poor effect on a lot of mold and yeast; hardly has any effect in alkaline solution. After sodium benzoate enters into the body, in the process of biotransformation, it would combine with glycine to be uric acid, or combine with glucuronic acid to be glucosiduronic acid, and all to be eliminated from the body in urine, not to accumulate in the body. As long as it is within the scope of the normal dosage, it would be harmless to the human body, and it is a safe preservatives. It also can be used for carbonated beverages, concentrated juice, margarine, chewing gum base, jam, jelly, soy sauce, etc. Human acceptable daily intake (ADI) < 5 mg/kg body weight (take benzoic acid as calculation basis). Sodium benzoate has big lipophilicity, and it is easy to penetrate cell membrane into the cells, interfere in permeability of cell membrane, and inhibit cell membrane’s absorption of amino acids; cause Ionization acidification of alkaline storage in the cell when entering into, inhibit activity of respiratory enzymes, and stop condensation reaction of acetyl coenzyme A, and thereby achieve the purpose of food antiseptic. The above information is edited by the Chemicalbook He Liaopu. Chemical properties White crystals or granules, or colorless powder, with sweet astringency. Soluble in water, ethanol, glycerol and methanol. Uses 1. Sodium benzoate is also an important preservative of acid type food. It transforms into effective form of benzoic acid during application. See benzoic acid for application range and dosage. In addition, it also can be used as fodder preservative. 2. Preservatives; antimicrobial agent. 3. Sodium benzoate agent is a very important preservative of acid type fodder. It transforms into effective form of benzoic acid during application. See benzoic acid for application range and dosage. In addition, it also can be used as food preservative. 4. Used in the research of pharmaceutical industry and plant genetic, also used as dye intermediates, fungicide and preservatives. 5. The product is used as food additive (preservative), fungicide in pharmaceutical industry, dye mordant, plasticizer in plastic industrial, and also used as organic synthetic intermediate of spices and others. Content Analysis Take dried sample 1.5g into a 250ml conical flask, dissolve it with 25ml water, and then add 50ml ether and bromophenol. Toxicity ADI 0～5mg/kg (take benzoic acid as calculation basis, total value of ADI including benzoic acid and its salts and esters; FAO/WHO, 2001). LD50 4070mg/kg (rats, by oral). GRAS(FDA，§184．1733，2000). Production methods 1. Neutralized by benzoic acid and sodium bicarbonate. Put water and sodium bicarbonate into the neutralizing pot, boil it and make it dissolved into sodium bicarbonate solution. Mix it with benzoic acid until PH value of the reaction solution reaches to 7-7.5. Heat it to emit over carbon dioxide, and then add active carbon to decolorize it for half an hour. Do suction filtration, after filtrate gets concentrated, put it into flaker tray, dry it to be sheets in the drum, crush it, and then sodium benzoate is made. Consumption rate of benzoic acid (99.5%) 1045kg/t and sodium bicarbonate (98%) 610kg/t. 2. Use 32% soda solution to neutralize benzoic acid in the pot to reach PH value of 7.5, and neutralization temperature is 70℃. Use 0.3% active carbon to decolorize the neutralized solution, vacuum filter it, concentrate, dry it and then it comes to powdered sodium benzoate. C6H5COOH+Na2CO3→C6H5COONa 3. To get it by toluene oxidation made benzoic acid reacting with sodium bicarbonate, sodium carbonate or sodium hydroxide. Description Sodium benzoate has the chemical formula NaC7H5O2; it is a widely used food preservative, with E number E211. It is the sodium salt of benzoic acid and exists in this form when dissolved in water. It can be produced by reacting sodium hydroxide with benzoic acid. Chemical Properties Benzoic acid is almost odorless or exhibits a sweet, faint, balsamic odor and a sweet–sour to acrid taste. For a detailed description, refer to Burdock (1997). Chemical Properties white crystalline powder Chemical Properties Sodium benzoate is a white crystalline solid. It is odorless and nonflammable Chemical Properties Sodium benzoate occurs as a white granular or crystalline, slightly hygroscopic powder. It is odorless, or with faint odor of benzoin and has an unpleasant sweet and saline taste. Occurrence Benzoic acid occurs naturally in many plants and in animals. The salt is not found to occur naturally. Uses Sodium benzoate is a preservative. It is bacteriostatic and fungistatic under acidic conditions. It is most widely used in acidic foods such as salad dressings (vinegar), carbonated drinks (carbonic acid), jams and fruit juices (citric acid), pickles (vinegar), and condiments. It is also used as a preservative in medicines and cosmetics. As a food additive, sodium benzoate has the E number E211. It is also used in fireworks as a fuel in whistle mix, a powder that emits a whistling noise when compressed into a tube and ignited. The fuel is also one of the fastest burning rocket fuels and provides a lot of thrust and smoke. It does have its downsides: there is a high danger of explosion when the fuel is sharply compressed because of the fuel's sensitivity to impact. Uses Sodium Benzoate is a preservative that is the sodium salt of benzoic acid. it converts to benzoic acid, which is the active form. it has a solubility in water of 50 g in 100 ml at 25°c. sodium benzoate is 180 times as soluble in water at 25°c as is the parent acid. the optimum functionality occurs between ph 2.5 and 4.0 and it is not recom- mended above ph 4.5. it is active against yeasts and bacteria. it is used in acidic foods such as fruit juices, jams, relishes, and bever- ages. its use level ranges from 0.03 to 0.10%. Uses Vasodilator Uses A benzene compound used as a synthetic reagent. Uses Antimicrobial agent, flavoring agent and adjuvant in food; not to exceed a maximum level of 0.1% in food (21 CFR, 184.1733, 582.3733). Antifungal and bacteriostatic preservative in pharmaceuticals at concentrations of ~0.1%. Clinical reagent (bilirubin assay). Uses sodium benzoate is a non-toxic, organic salt preservative that is particularly effective against yeast, with some activity against molds and bacteria. It is generally used in concentrations of 0.1 to 0.2 percent. Definition ChEBI: An organic sodium salt resulting from the replacement of the proton from the carboxy group of benzoic acid by a sodium ion. Production Methods Sodium benzoate is prepared by adding benzoic acid to a hot concentrated solution of sodium carbonate until effervescence ceases. The solution is then evaporated, cooled and allowed to crystallize or evaporate to dryness, and then granulated. Production Methods Prepared by the treatment of benzoic acid with either sodium carbonate or sodium bicarbonate. Definition sodium benzoate: An either colourlesscrystalline or white amorphouspowder, C6H5COONa, soluble inwater and slightly soluble in ethanol.It is made by the reaction of sodiumhydroxide with benzoic acid and isused in the dyestuffs industry and asa food preservative. It was formerlyused as an antiseptic. Preparation Produced by the neutralization of benzoic acid with sodium bicarbonate, sodium carbonate or sodium hydroxide. General Description Sodium benzoate is a sodium salt of benzoic acid, that is freely soluble in water compared to benzoic acid. It is generally used as an antimicrobial preservative in cosmetics, food, and pharmaceuticals. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Hazard Use in foods limited to 0.1%. Pharmaceutical Applications Sodium benzoate is used primarily as an antimicrobial preservative in cosmetics, foods, and pharmaceuticals. It is used in concentrations of 0.02–0.5% in oral medicines, 0.5% in parenteral products, and 0.1–0.5% in cosmetics. The usefulness of sodium benzoate as a preservative is limited by its effectiveness over a narrow pH range. Sodium benzoate is used in preference to benzoic acid in some circumstances, owing to its greater solubility. However, in some applications it may impart an unpleasant flavor to a product. Sodium benzoate has also been used as a tablet lubricant at 2–5% w/w concentrations. Solutions of sodium benzoate have also been administered, orally or intravenously, in order to determine liver function. Biochem/physiol Actions Sodium benzoate also has pharmaceutical applications and is component of syrup and transparent tablet. High levels of sodium benzoate may trigger histamine release and also induce cell damage. It is recommended for the treatment of urea cycle disorders. However, high levels of sodium benzoate may contribute to glycine deficiency and may impose neuromodulatory effects. Safety Profile Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion, intramuscular, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. Larger doses of 8-10 g by mouth may cause nausea and vomiting. Small doses have little or no effect. Combustible when exposed to heat or flame. When heated to decomposition it emits toxic fumes of Na2O. See also BENZOIC ACID. Safety Ingested sodium benzoate is conjugated with glycine in the liver to yield hippuric acid, which is excreted in the urine. Symptoms of systemic benzoate toxicity resemble those of salicylates. Whereas oral administration of the free-acid form may cause severe gastric irritation, benzoate salts are well tolerated in large quantities: e.g. 6 g of sodium benzoate in 200mL of water is administered orally as a liver function test. Clinical data have indicated that sodium benzoate can produce nonimmunological contact urtcaria and nonimmunological immediate contact reactions. However, it is also recognized that these reactions are strictly cutaneous, and sodium benzoate can therefore be used safely at concentrations up to 5%. However, this nonimmunological phenomenon should be considered when designing formulations for infants and children. Other adverse effects include anaphylaxis and urticarial reactions, although a controlled study has shown that the incidence of urticaria in patients given benzoic acid is no greater than that with a lactose placebo. It has been recommended that caffeine and sodium benzoate injection should not be used in neonates; however, sodium benzoate has been used by others in the treatment of some neonatal metabolic disorders. It has been suggested that there is a general adverse effect of benzoate preservatives on the behavior of 3-yearold children, which is detectable by parents, but not by a simple clinical assessment. The WHO acceptable daily intake of total benzoates, calculated as benzoic acid, has been estimated at up to 5 mg/kg of bodyweight. LD50 (mouse, IM): 2.3 g/kg LD50 (mouse, IV): 1.4 g/kg LD50 (mouse, oral): 1.6 g/kg LD50 (rabbit, oral): 2.0 g/kg LD50 (rat, IV): 1.7 mg/kg LD50 (rat, oral): 4.1 g/kg Safety In combination with ascorbic acid (vitamin C, E300), sodium benzoate and potassium benzoate form benzene, a known carcinogen. However, in most beverages that contain both, the benzene levels are below those considered dangerous for consumption. Heat, light and shelf life can affect the rate at which benzene is formed. Potential Exposure Sodium benzoate is used as a food and feed additive, flavor, packaging material; pharmaceutical; preservative for food products and tobacco; anti-fungal agent; antiseptic, rust, and mildew inhibitor; intermediate in the manufacture of dyes. Used as a human hygiene biocidal product. storage Aqueous solutions may be sterilized by autoclaving or filtration. The bulk material should be stored in a well-closed container, in a cool, dry place. Shipping UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. Purification Methods Crystallise it from EtOH (12mL/g). [Beilstein 9 IV 27.] Properties and Applications TEST ITEMS SPECIFICATION APPEARANCE WHITE POWDER CONTENT OF SODIUM BENZOATE 99.0% min DRY LOSS 0.10% max pH VALUE 8 TOTAL CHLORIDE 300 ppm max TRANSPARENCE PASS TOTAL HEAVY METAL 0.001% max As CONTENT 0.0002% max Mechanism of food preservation The mechanism starts with the absorption of benzoic acid into the cell. If the intracellular pH changes to 5 or lower, the anaerobic fermentation of glucose through phosphofructokinase is decreased by 95 %, thereby inhibiting the growth and survival of micro-organisms that cause food spoilage. Incompatibilities Incompatible with quaternary compounds, gelatin, ferric salts, calcium salts, and salts of heavy metals, including silver, lead, and mercury. Preservative activity may be reduced by interactions with kaolin or nonionic surfactants. Incompatibilities Dust may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Regulatory Status GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; oral capsules, solutions and tablets; rectal; and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Sodium benzoate Preparation Products And Raw materials Raw materials Sodium hydroxide-->Toluene-->Sodium carbonate-->Sodium bicarbonate-->CARBON DIOXIDE-->Activated carbon,decolor-->Benzoic acid-->Saccharin sodium Preparation Products Anthranilic acid-->Methyl anthranilate-->N-Boc-cis-4-Hydroxy-L-proline methyl ester-->Benzyl benzoate-->Bentazone-->3-Aminobenzoic acid-->Penetrating agent-->Bromelain-->Cyclohexanecarboxylic acid-->8-CHLOROMETHYL-7-METHOXY-3-METHYL FLAVONE-->2-METHYLBENZANILIDE-->2-(3-Amino-4-chloro-benzoyl)benzoic acid-->2-Bibenzylcarboxylic acid-->3-METHYL-5-PHENYL-4-ISOXAZOLECARBOXYLIC ACID-->Acetrizoic acid-->2-Methyoxy-3-methyl-2-phenyl-4H-benzo-g-pyranone-->Benzoic acid (trifluoromethanesulfonic acid)anhydride-->Silk essence-->ZINC BENZOATE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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