China Largest Manufacturer factory sales Oleanolic Acid CAS 508-02-1

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Oleanolic acid Basic information Description References Product Name: Oleanolic acid Synonyms: (3-beta)-3-hydroxyolean-12-en-28-oicacid;(3-beta)-olean-12-en-28-oicaci;(3beta)-olean-12-en-28-oicaci;3-beta-hydroxy-olean-12-en-28-oicaci;astrantiageninc;Oleanolic acid Extract;Olean-12-en-28-oicacid, 3-hydroxy-, (3β)-;Oleanic acid，Oleanolic acid CAS: 508-02-1 MF: C30H48O3 MW: 456.7 EINECS: 208-081-6 Product Categories: Natural Plant Extract;Intermediates & Fine Chemicals;Anti-proliferative AgentsAsymmetric Synthesis;Complex MoleculesNutrition Research;Pharmaceuticals;Steroids;Isoprenoid/terpenoidCancer Research;Phase I Enzyme Inhibitors;Phase I Enzyme InhibitorsCancer Research;Biochemicals Found in Plants;Cancer Research;Chemopreventive Agents;Chiral Building Blocks;Multidrug Resistance;Pentacyclic triterpenes;Tri-Terpenoids;Biochemistry;Terpenes;Terpenes (Others);chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;Pyrazoles Mol File: 508-02-1.mol   Oleanolic acid Chemical Properties Melting point  >300 °C (lit.) alpha  D20 +83.3° (c = 0.6 in chloroform) Boiling point  502.79°C (rough estimate) density  1.0261 (rough estimate) refractive index  1.4940 (estimate) storage temp.  2-8°C solubility  Chloroform (Very Slightly), DMSO (Slightly, Heated), Methanol (Slightly, Heated) pka 2.52(at 25℃) form  neat color  light yellow Merck  14,6827 InChIKey NZQIXFRGWXNLSP-IDYUENATSA-N CAS DataBase Reference 508-02-1(CAS DataBase Reference) EPA Substance Registry System Oleanolic acid (508-02-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37/39-60-37 WGK Germany  2 RTECS  RK0177965 TSCA  Yes HS Code  29181990 MSDS Information Provider Language 3beta-Hydroxyolean-12-en-28-oic acid English SigmaAldrich English   Oleanolic acid Usage And Synthesis Description Oleanolic acid or oleanic acid is a naturally occurring pentacyclic triterpenoid with the formula of C30H48O3. It was found in the non-glyceride fraction of olive pomace oil and is widely distributed in food and plants where it exists as a free acid or as an aglycone precursor for triterpenoid saponins, in which it can be linked to one or more sugar chains. It is biosynthesized from lupane. It can rearrange to the isomer, ursolic acid, or be oxidized to taraxasterol and amyrin. Oleanolic acid and its derivatives possess several promising pharmacological activities, such as hepatoprotective effects, and anti-inflammatory, antioxidant, or anticancer activities. References 1.https://en.wikipedia.org/wirki/Oleanolic_acid 2.https://www.ncbi.nlm.nih.gov/mesh/68009828 3.//www.sciencedirect.com/science/article/pii/S0031942212000027 4.//www.adooq.com/oleanolic-acid-caryophyllin.html Description The ingredient is mainly extracted from the leaves of muxilan 木樨榄 (Olea europaea). Besides, it is found in the fruit of ligustrum lucidum ait, the whole grass of swertia mileensis t.n.he et w.l.shi, s. mussotii franch, the leaves and roots of astrantia major, the root bark and stem bark of aralia chinensis, the roots of hemsleya macrosperma c.y.wu , the roots of hemsleya amabilis diels, and the roots of hemsleya chinensis cogn. There is a long history in the herb and fruit which contain oleanolic acid. They play an important role in the treatment of various diseases. Oleanolic acid may be the most effective component in various Chinese medicines. Chemical Properties White Solid Physical properties Appearance: Olea europaea exists in white needle crystal with ethanol or methanol. Melting point: It melts at 306–310 °C. Solubility: The ingredient is insoluble in water. Specific optical rotation: Polarized light rotates +83.3° when it passes through chloroform with concentration of 6 mol/L. History The chemical formula was first identified in 1918. In 1960, Khastgir purified the compound for the first time. Corey identified the structure of oleanolic acid in 1993. Now the compound has been made into a drug and is being marketed in China. As early as 2002, the tablet form of oleanolic acid was listed. In 2010, capsule preparations came into the market, and to date, there is no other listed preparation. Sanofi treated it as antiulcer and NSAIDs candidate in abroad. Although it has anti-inflammatory and anti-ulcer effects, Sanofi stopped the study of developing oleanolic acid into a drug in 1989. Uses A triterpenoid known for its anti-inflammatory properties, is commonly present in several medicinal plants. Inhibits secretory phospholipase A2. Uses A triterpenoid known for its anti-inflammatory properties, is commonly present in several medicinal plants. Indications It is included in the Pharmacopoeia of the People’s Republic of China (Part 2, volume 3), the British Pharmacopoeia (2017), and the European Pharmacopoeia (8.7th ed.). It is mainly used for the adjuvant treatment of acute infectious icteric hepatitis and acute and chronic hepatitis. It also can be utilized in psoriasis, rheumatoid arthritis, nephritic edema, ascites, stomach with turbid, metrorrhagia, bruises, carbuncle, soreness and weakness of the waist and knees, fetal irritability and so on. Definition ChEBI: A pentacyclic triterpenoid that is olean-12-en-28-oic acid substituted by a beta-hydroxy group at position 3. General Description Oleanolic acid is a hydroxyl pentacyclic triterpenoic acid (HPTA), which exhibits antibacterial, antitumor and antileishmanial activity. Biochem/physiol Actions Triterpenoid isolated from medicinal plants. Antitumor and hepatoprotective agent. Oleanolic acid has therapeutic potential for neurodegenerative diseases. Pharmacology Liver protection: Pretreatment of 100 mg/kg once a day for 3 days can protect the liver and decrease the activity of enzymes. It achieves by increasing the amount of metallothioneins and liver glucoside transferases to prevent glutathione emptying, to inhibit several subtypes of P450 oxidase, and to prevent combination with toxic substances. Antimicrobial and antiviral effect: Oleanolic acid may inhibit the proliferation or production of NO induced by interferon or in the macrophages by competitively binding to the enzymes necessary for the growth and reproduction of microorganisms or virus and play an anti-inflammatory and antiviral role. EC50 of HIV-1- infected H9 cells is 3.4 mol/L. Effects on metabolism of glucose and lipid: The treatment of 50–100 mg/kg for 4 days achieves the glucosidase activity inhibition, reduction of glucose absorption, inhibition of glycogen phosphorylase, activation of glycogen synthesis, inhibition of protein tyrosine phosphatase 1B, regulation of insulin signaling pathway, and increase of insulin sensitivity, and it may also be achieved by inhibiting the transport of glucose from the stomach to the intestine and transport activity of intestinal villi. 200 mg/kg suspension administrated by gavage for 4 weeks decreases the level of triglycerides, cholesterol, and β-lipoprotein in high-fat animal, and it contributes to increased platelet swimming rate and decreased blood viscosity Effects on immunologic function: 60 mg/kg intraperitoneal injection may regulate the immune system by inhibiting type I allergic reaction, promoting proliferation of lymphocyte and inhibiting enzyme C-3 in the traditional complement pathway. Antioxidant effect: It fights against lipid peroxidation by scavenging free radicals. Other functions: 10–5 mol/L oleanolic acid may inhibit the activity of DNA ligase I active site. It exerts anticancer and anti-mutation effects, and IC50 value is2.2×105 mol/L in inhibiting ornithine decarboxylase (ODC) induced by external TPA at the transcriptional level. Oleanolic acid in polyvinylpyrrolidone suspension at the dose of 16 mg/kg by intragastric administration for 30 days also reversibly decreases quality and exercise capacity of mouse sperms. It is reported that it is consistent with the single compartment model, or noncompartmental model, and may be distributed in the compound in accordance with the two compartment models. Eventually, it will be eliminated by P450 oxidase in the liver. Clinical Use It is reported that contrast with Western medicine, the 60~90 mg/d oleanolic acid tablets supplemented with vitamin B can treat acute and chronic hepatitis, with effective rates of 94.4% and 69.81%, respectively, in clinical results. It has been listed on the drug manual as adjuvant therapy for acute and chronic hepatitis.   Oleanolic acid Preparation Products And Raw materials Preparation Products Bardoxolone methyl-->Ethyl (3beta)-3-hydroxyolean-12-en-28-oate-->3-Oxo-olean-12-en-28-oic acid-->Bardoxolone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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