China Largest Manufacturer factory sales Ethylparaben CAS 120-47-8

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Ethylparaben Basic information Product Name: Ethylparaben Synonyms: 4-Carbethoxyphenol;nipaginaa;Nipazin A;nipazina;Para-hydroxybenzoic acid ethyl ester;p-Carbethoxyphenol;p-Hydroxybenzoic ethyl ester;p-hydroxy-benzoicaciethylester CAS: 120-47-8 MF: C9H10O3 MW: 166.17 EINECS: 204-399-4 Product Categories: Aromatic Esters;Aromatics;Pharmaceutical Raw Materials;API;PROVENTIL Mol File: 120-47-8.mol   Ethylparaben Chemical Properties Melting point  114-117 °C (lit.) Boiling point  297-298 °C (lit.) density  1.1708 (rough estimate) vapor pressure  0.00012 hPa (25 °C) refractive index  1.5286 (estimate) Fp  297-298°C storage temp.  2-8°C solubility  Very slightly soluble in water, freely soluble in ethanol (96 per cent) and in methanol. pka 8.31±0.13(Predicted) form  Crystalline Powder color  White PH 4.5-5.5 (H2O, 20°C) (saturated solution) Water Solubility  Slightly soluble in water. Merck  14,3837 BRN  1101972 Stability: Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. CAS DataBase Reference 120-47-8(CAS DataBase Reference) NIST Chemistry Reference Ethylparaben(120-47-8) EPA Substance Registry System Ethylparaben (120-47-8)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-24/25 WGK Germany  1 RTECS  DH2190000 Autoignition Temperature 495 °C TSCA  Yes HS Code  29182930 Hazardous Substances Data 120-47-8(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: > 2000 mg/kg MSDS Information Provider Language p-Hydroxybenzoate ethyl ester English ACROS English SigmaAldrich English ALFA English   Ethylparaben Usage And Synthesis Chemical Properties Ethylparaben occurs as a white, odorless or almost odorless, crystalline powder. Uses Ethylparaben is mainly used as antiseptics in cosmetics, food and medicine. It is also can be used as feed preservatives and antiseptic for bacteria. Ethylparaben is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination. In most formulations, parabens are used at very low levels ranging from 0.01 to 0.3%. Ethylparaben, a novel sorbent for solid-phase extraction, was used to study its retention property. It has high extraction efficiency towards the compounds tested owing to the electrostatic interaction, hydrophobic interaction and hydrogen bonding. Definition ChEBI: Ethylparaben is an ethyl ester resulting from the formal condensation of the carboxy group of 4-hydroxybenzoic acid with ethanol, It has a role as an antimicrobial food preservative, an antifungal agent, a plant metabolite and a phytoestrogen. It is a paraben and an ethyl ester. Production Methods Ethylparaben is prepared by the esterification of p-hydroxybenzoic acid with ethanol (95%). Synthesis Reference(s) The Journal of Organic Chemistry, 39, p. 3343, 1974 DOI: 10.1021/jo00937a007 Pharmaceutical Applications Ethylparaben is widely used as an antimicrobial preservative in cosmetics,food products, and pharmaceutical formulations. It may be used either alone or in combination with other paraben esters or with other antimicrobial agents. In cosmetics it is one of the most frequently used preservatives. The parabens are effective over a wide pH range and have a broad spectrum of antimicrobial activity, although they are most effective against yeasts and molds. Owing to the poor solubility of the parabens, paraben salts, particularly the sodium salt, are frequently used. However, this may cause the pH of poorly buffered formulations to become more alkaline. Safety Ethylparaben and other parabens are widely used as antimicrobial preservatives in cosmetics, food products, and oral and topical pharmaceutical formulations. Systemically, no adverse reactions to parabens have been reported, although they have been associated with hypersensitivity reactions. Parabens, in vivo, have also been reported to exhibit estrogenic responses in fish.(10) The WHO has set an estimated total acceptable daily intake for methyl-, ethyl-, and propylparabens at up to 10 mg/kg body-weight. LD50 (mouse, IP): 0.52 g/kg LD50 (mouse, oral): 3.0 g/kg storage Aqueous ethylparaben solutions at pH 3–6 can be sterilized by autoclaving, without decomposition. At pH 3–6, aqueous solutions are stable (less than 10% decomposition) for up to about 4 years at room temperature, while solutions at pH 8 or above are subject to rapid hydrolysis (10% or more after about 60 days at room temperature). Ethylparaben should be stored in a well-closed container in a cool, dry place. Incompatibilities The antimicrobial properties of ethylparaben are considerably reduced in the presence of nonionic surfactants as a result of micellization. Absorption of ethylparaben by plastics has not been reported, although it appears probable given the behavior of other parabens. Ethylparaben is coabsorbed on silica in the presence of ethoxylated phenols. Yellow iron oxide, ultramarine blue, and aluminum silicate extensively absorb ethylparaben in simple aqueous systems, thus reducing preservative efficacy. Ethylparaben is discolored in the presence of iron and is subject to hydrolysis by weak alkalis and strong acids. Regulatory Status Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Ethylparaben Preparation Products And Raw materials Raw materials Ethanol-->Sulfuric acid-->Activated carbon,decolor-->4-Hydroxybenzoic acid-->Ethyl 4-etoxybenzoate Preparation Products 2,6-Dichlorophenol-->Dazoxiben-->Propylparaben-->Gabexate mesylate-->ETHYL 4-(2-CHLOROETHOXY)BENZOATE-->3,5-Dichloro-4-hydroxybenzoic acid-->Ethyl 3,4-dihydroxybenzoate-->Sorbic acid-->4-(MethoxyMethoxy)benzoicacid-->4-N-BUTOXYBENZOYL CHLORIDE-->4-BENZYLOXYBENZHYDRAZIDE-->4-(Hydroxymethyl)cyclohexanol(cis- and trans- mixture)-->ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate-->Kayalon Polyester Light Red BL-SE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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