tert-Butyl carbamate 4248-19-5

Details:

Introduction: 

tert-Butyl carbamate Basic information

Product Name:	tert-Butyl carbamate
Synonyms:	tert-Butylcarbamate,98+%;tert-Butoxycarbonylamine;Carbamic Acid tert-Butyl EsterBoc-amide;tert-Butyl carbamate,Boc-amide;N-t-Butoxycarbonyl-amide(Boc-NH2);ert-Butyl carbamate;Boc-NH2 N-t-Butoxycarbonyl-aMide;tert-Butyl carbaMate 5GR
CAS:	4248-19-5
MF:	C5H11NO2
MW:	117.15
EINECS:	224-209-3
Product Categories:	Protected Amino Acids;pharmacetical
Mol File:	4248-19-5.mol

tert-Butyl carbamate Chemical Properties

Melting point	105-108 °C (lit.)
Boiling point	218.95°C (rough estimate)
density	1.1274 (rough estimate)
refractive index	1.4206 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Needles
pka	13.59±0.50(Predicted)
color	White to slightly yellow
Water Solubility	Soluble in methylene chloride, chloroform, and alcohols. Slightly soluble in petroleum ether and water.
BRN	1744500
CAS DataBase Reference	4248-19-5(CAS DataBase Reference)
NIST Chemistry Reference	Tert-butyl carbamate(4248-19-5)

Safety Information

Hazard Codes	Xi
Risk Statements	36
Safety Statements	39-26-24/25
WGK Germany	3
HS Code	29241990

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

tert-Butyl carbamate Usage And Synthesis

Chemical Properties	White to slightly yellow needles
Uses	tert-Butyl carbamate is used in palladium-catalyzed synthesis of N-Boc-protected anilines. It was used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.
Uses	tert-Butyl carbamate was used in palladium-catalyzed synthesis of N-Boc-protected anilines. It was used in the synthesis of tetrasubstituted pyrroles, functionalized with ester or ketone groups at C-3 position.
Synthesis Reference(s)	The Journal of Organic Chemistry, 28, p. 3421, 1963 DOI: 10.1021/jo01047a033
General Description	Palladium-catalyzed cross-coupling reaction of tert-butyl carbamate with various aryl(Het) halides with Cs2CO3 as base in 1,4-dioxane (solvent) has been investigated.

tert-Butyl carbamate Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Chloroform-->Ammonia-->Di-tert-butyl dicarbonate-->N-Bromosuccinimide-->Trifluoroacetic acid-->tert-Butanol-->Benzoyl peroxide-->Allyl chloride-->PERCHLORIC ACID-->Sodium cyanate
Preparation Products	Docetaxel-->METHYL PENT-4-YN-2-YLCARBAMATE-->(R)-Styrene oxide-->N-Boc-propargylamine-->N-Boc-5-amino-2-fluoropyridine-->Carbamic acid, acetyl-, 1,1-dimethylethyl ester (9CI)-->N-(TERT-BUTOXYCARBONYL)-3-BROMOANILINE-->(3R,4S)-rel-1-Boc--3,4-diaMinopyrrolidine-->TERT-BUTYL 4-CYANOPHENYLCARBAMATE

 

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