China Largest Manufacturer factory sales Chitosan CAS 9012-76-4

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Chitosan Basic information Description Physical and Chemical Properties Physiological role and efficacy Antibacterial activity Uses preparation Product Name: Chitosan Synonyms: Chitosan from shrimp shells ;kytexm;poliglusam;seacuref;seacureplus;CHITOSANNANOPARTICLES;LOWMOLECULARWEIGHTCHITOSAN;HIGHMOLECULARWEIGHTCHITOSAN CAS: 9012-76-4 MF: C6H11NO4X2 MW: 161.16 EINECS: 618-480-0 Product Categories: Biochemicals and Reagents;Carbohydrates;Carbohydrates A to Z;Cell Culture;Chitosan;Enzyme Substrates;Enzymes;Inhibitors;Materials Science;Natural Polymers;Polymer Science;Polymers;Polysaccharide;Vaccine Adjuvants;Miscellaneous Natural Products;Biochemistry;Polysaccharides;Sugars;Nutritional Supplements;Dextrins、Sugar & Carbohydrates;Activity Other;Carbohydrate adjuvants;Carbohydrates A-C;Chitosan and Chitin;Activity;and Substrates;Vaccine Production;Oligosaccharide，Biostimulate;Food additives;VX:15689727968;9012-76-4 Mol File: 9012-76-4.mol   Chitosan Chemical Properties Melting point  102.5 °C density  1 g/cm3 storage temp.  2-8°C solubility  dilute aqueous acid (pH <6.5).: soluble form  (Coarse ground flakes and powder) color  White to Off-white Stability: Stable. Incompatible with strong oxidizing agents. CAS DataBase Reference 9012-76-4 EPA Substance Registry System Chitosan (9012-76-4)   Safety Information Hazard Codes  Xn Risk Statements  20/21/22-36/37/38 Safety Statements  24/25-36-26 WGK Germany  - RTECS  FM6300000 F  3 TSCA  Yes HS Code  39139000 MSDS Information Provider Language Chitosan English SigmaAldrich English ACROS English   Chitosan Usage And Synthesis Description Chitosan is a unique basic polysaccharide obtained by N-deacetylation of chitin in an alkaline medium. This alkaline consists mainly of β-(1-4)-2-acetamido-2-deoxy-D-glucose units. Besides, it is the second most abundant biopolymer on Earth after cellulose that can be found in crustacean shells and the cell walls of fungi. Another feature of chitosan is that it is a copolymer of N-acetyl-D-glucosamine and D-glucosamine. Protonation of the NH2 functional group on the C-2 position of the D-glucosamine repeating unit makes it easily soluble in aqueous acidic media and it results in the conversion of the polysaccharide to a polyelectrolyte in acidic media. Chitosan shows more potential than chitin for use in different applications as a result of the presence of its NH2 groups. It has good properties including biodegradability, biocompatibility, and antibacterial activity. Chitosan has abundant applications in different fields because it is the one and only pseudonatural cationic polymer. Generally it is prepared by deacetylation of α-chitin using 40%-50% aqueous alkali solution at 100℃-160℃. This preparation takes a few hours. As a result of this, newly derived chitosan has a degree of deacetylation (DD) up to 0.95. Chitosan is provided with high adsorption capacity and selectivity by many -NH2 and -OH groups that can chelate heavy metal ions. The intermolecular and intramolecular hydrogen bonds are numerous in chitosan molecules. The packing structure of chitosan in the three unit cell directions stabilizes strongly and gives the power to chitosan not to melt at all. Chitosan dissolves only in certain organic acids, like formic, acetic, propionic, lactic, citric, and succinic acids, and in some inorganic solvents, like hydrochloric, phosphoric, and nitric acid. Physical and Chemical Properties Chitosan is the second most abundant (only next to cellulose) biopolymer and is widely distributed. It is mainly distributed in many lower animals particularly the shells of arthropods such as shrimp, crabs and insects. It is also presented in the cell wall of in lower plants such as algae and fungus. Chitosan can be obtained through the deacetylation of chitin. Under the conditions of 40% NaOH and 100 ℃, chitin is subject to deacetylation reaction and give chitosan. It appears as a white or off-white translucent sheet-like gray solid. It is insoluble in water and alkali, but can be dissolved in most kinds of dilute acid including formic acid, acetic acid and hydrochloric acid. The molecular structure of chitosan is similar to that of the cellulose with the only difference being that the C2-position connects the amino group (-NH2). So it has affinity to the paper fibers, evolving strong ionic bonding and hydrogen bonding. Moreover, the chitosan has film-forming property that can help to improve the surface strength of the paper, thus becoming one of enhancers applied to specialty paper. Chitosan appears as powder state and is tasteless, odorless with its aqueous solution having some spicy sense. Adding chitosan to the food for making soup and accompanied with a certain degree of cooking, frying, baking and other heat treatment will have its structure be not changed. Under the protection of nitrogen gas, even upon being heated to 250 ℃, the decomposition phenomenon does not occur. At room temperature, placing chitosan powder in natural place free of sunshine for preservation of 181d causes no significant changes in aspects including appearance, solubility, and the degree of deacylation. The biscuits supplemented with chitosan, when packaged in a state with the temperature of 40 ℃, the relative humidity of 75% environment for preservation of 80d, have their content of dietary fiber and chitosan remain not changed. The chemical structure of chitin, chitosan and cellulose Physiological role and efficacy Chitosan is a dietary fiber with various efficacies such as lowering serum cholesterol, regulation of intestinal flora and reducing blood pressure and other effects. After the human intake of chitosan, fecal analysis has showed that it is hardly digested and absorbed, and therefore belonging to a dietary fiber. Studies have shown that chitosan has some characteristics of dietary fiber, such as water retention, swelling property, adhesion property and difficult for digestion and absorbing, etc. It can promote gastrointestinal peristalsis, adhesion of toxic substances, increase stool volume, lower abdominal and intestinal pressure, improve constipation and prevent colorectal cancer. Chitosan has similar physical and chemical property as gastric mucin with effects of inhibiting gastric acid, anti-ulcer and anti-inflammatory effect. It is an anti-gastric acid polysaccharide with swelling into sticky syrup with adhesion property upon coming across water. It can form protective film in the stomach to reduce the stimulation of gastric acid on the ulcer surface. Food safety: when the dose of chitosan feeding animal reaches 20% of the feed, cases of animal deaths have been reported. It is believed that it is due to the gel formation in animal offal caused by high concentrations of the chitosan that inhibit the nutrient absorption by animal. At present, we need to systematically study the physiological roles of the high viscosity chitosan macromolecules and small molecules of low viscosity as well as conduct long-term chronic toxicology test on the safety and metabolism of the chitosan of clear source. The main resource chitin, chitosan Antibacterial activity Chitosan has broad antibacterial activity, but with different concentrations of chitosan having different antibacterial capability. For example, when the chitosan concentration is 0.1%, it can completely inhibit the reproduction of all kinds of fungi Fusarium genus within 8d but this concentration has no effect on Rhizopus, Penicillium, Aspergillus and other fungus. At a concentration of 0.4%, it also has strong inhibitory effect against Escherichia coli, Proteus vulgaris, Bacillus subtilis, and Staphylococcus aureus. In addition, chitosan of different degrees of deacylation have their antibacterial properties being also different with mold of high level of deacylation having strong anti-mold effect. One reason is that the chitosan interacts with the surface portion of mold cells, increasing the cell permeability. Preservatives with chitosan being combined with sodium acetate, adipic acid have more significant antibacterial effect without affecting the flavor of food. Antibacterial effect of chitosan mainly includes the following two mechanisms: one is that chitosan adhere to the cell surface and form a layer of polymer film, preventing the transport of the nutrients into the cells, thus playing the role of antimicrobial sterilization; the other mechanism is that: chitosan enters into the cell body through penetration into the cell body, adhering the anion-containing cytoplasm inside cells and cause flocculation, disrupting the normal physiological activities of cells, thus killing the bacteria. Because the cell wall structure of gram-positive bacteria and gram-negative bacteria are different with the two actions having different effects, so chitosan of different molecular weight has different antibacterial mechanism. The above information is edited by the chemicalbook of Dai Xiongfeng. Uses Chitin and chitosan are natural biopolymers that have various properties such as antimicrobial activity, hemostatic agent, metal-chelating, molecular affinity, and wound-healing agent. For a wide range of uses of these polymers, different modifications have been studied by different researchers. Electrospun fibers of chitin and chitosan could therefore be of great interest in various application fields such as tissue engineering, biomedical, cosmetics, and many industrial applications, such as wastewater treatment. Chitosan has various effects such as improving immunity, activation of cells, preventing cancer, lowering blood pressure, lowering blood pressure, anti-aging and regulating body environment. It can be used in medicine, health care and food fields. In the field of environmental protection, chitosan can be used in sewage treatment, protein recovery, and water purification. In functional materials, the chitosan can be used in film material, carriers, adsorbents, fibers, medical materials and the like. In the field of light textile, chitosan can be used for fabric finishing, health underwear and paper additives. In the field of agriculture, it can be applied to feed additives, seed treatment, soil improvement, and preservation of fruit. In the field of tobacco, tobacco Chitosan is an excellent sheet gel and can also improve the taste with being non-toxic and odorless upon burning. preparation Chitosan is prepared by a degree of acetylation. Acetyl groups are removed during the deacetylation process and Mw changes due to the depolymerization reaction. There are two processes, that is, the enzymatic process and chemical process, and chitosan is produced by chemical process. It is preferable for large-scale production. Glycosidic bonds are attracted toward acids and alkalis. Chitin is processed homogeneously or heterogeneously. In the homogeneous method, chitin is diffused in concentrated alkali at 25℃ for 3h and allowed to disperse in compressed ice at around 0℃. In the heterogeneous process the chitin is treated with hot high-concentration alkali and then washed with distilled water until the pH is neutral. It is difficult to produce higher deacetylated chitosan. The addition of thiophenol as a catalyst during the process would minimize the degradation by trapping oxygen and enhance the effective deacetylation. The effective deacetylation process of chitin achieves the preparation of chitosan if the alkali concentration is four times greater than the total amino group in the polysaccharide at a temperature around 100℃ for the duration of 1 h. It is recommended to use low concentration alkali and a short contact time between alkali and polymer. Chemical deacetylation has many disadvantages like high energy consumption and environmental pollution problems. An alternative method of enzyme deacetylation has been developed to overcome these drawbacks. Chitin deacetylation enzyme acts as a catalysis to hydrolyze N-acetamide bonds. This enzyme is extracted from the fungi Mucor rouxii, Absidia coerulea, Aspergillus hidulans, and two strains of Celletotrichum lindemuthianum. This enzyme is thermally stable and has a binding affinity toward β-(1, 4)-linked N-acetyl-D-glucosomine polymers. Most of the time the enzyme process is carried out in both batch and continuous culture. In the batch process the Mw of chitosan is lower with respect to time. Moreover, chitosan of higher Mw is obtained in a specific culture even though the yield is comparatively low. Chemical Properties Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’. Occurrence Chitosan comes from the shell of marine crustaceans. Uses Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.Flocculant, protein precipitation, encapsulating agent and aqueous thickener. Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application. Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications Uses Ideal for wound healing and hemostasis; biosurgery and ophthalmology; scaffold and cell therapy; and drug delivery and vaccines Uses chitosan is a film-forming polysaccharide that can aid the skin’s moisture content and moisture-retention capacity by preventing transepidermal water loss. In addition, it appears to help bind other ingredients (for example, to increase liposome stability), thereby increasing the availability of active ingredients to the skin. Anti-bacterial properties are also associated with chitosan, as well as an ability to enhance the microbiological stability of a preparation. Some studies show that it can help improve the water-resistance properties of sun protection creams and lotions, and the longevity of a fragrance’s scent (the perfume adheres more strongly to the skin and evaporates more slowly, over a longer period). It acts as a skin conditioner, improving skin softness and suppleness. It may be found in moisturizers, sunscreens, and acne preparations, in addition to hair care products. It is the decarboxylated form of chitin and can hold water without creating a feeling of tackiness in a cosmetic preparation. According to some chitosan suppliers, the use of shrimp shells is one of the most important sources. They consist of 30–35 percent protein, 30–35 percent minerals, and 15–20 percent chitin, with some traces of lipids, dyes, and soluble proteins. Production Methods Chitosan is manufactured commercially by chemically treating the shells of crustaceans such as shrimps and crabs. The basic manufacturing process involves the removal of proteins by treatment with alkali and of minerals such as calcium carbonate and calcium phosphate by treatment with acid. Before these treatments, the shells are ground to make them more accessible. The shells are initially deproteinized by treatment with an aqueous sodium hydroxide 3–5% solution. The resulting product is neutralized and calcium is removed by treatment with an aqueous hydrochloric acid 3–5% solution at room temperature to precipitate chitin. The chitin is dried so that it can be stored as a stable intermediate for deacetylation to chitosan at a later stage. NDeacetylation of chitin is achieved by treatment with an aqueous sodium hydroxide 40–45% solution at elevated temperature (1108℃), and the precipitate is washed with water. The crude sample is dissolved in acetic acid 2% and the insoluble material is removed. The resulting clear supernatant solution is neutralized with aqueous sodium hydroxide solution to give a purified white precipitate of chitosan. The product can then be further purified and ground to a fine uniform powder or granules. The animals from which chitosan is derived must fulfil the requirements for the health of animals suitable for human consumption to the satisfaction of the competent authority. The method of production must consider inactivation or removal of any contamination by viruses or other infectious agents. General Description Chitosan is a linear amino polysaccharide composed of approximately 20% β1,4-linked N-acetyl-D-glucosamine (GlcNAc) and approximately 80% β1,4-linked D-glucosamine (GlcN) that is prepared by the partial deacetylation of chitin in hot alkali. Pharmaceutical Applications Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies. These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery. Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes. Safety Chitosan is being investigated widely for use as an excipient in oral and other pharmaceutical formulations. It is also used in cosmetics. Chitosan is generally regarded as a nontoxic and nonirritant material. It is biocompatible with both healthy and infected skin. Chitosan has been shown to be biodegradable. LD50 (mouse, oral): >16 g/kg storage Chitosan powder is a stable material at room temperature, although it is hygroscopic after drying. Chitosan should be stored in a tightly closed container in a cool, dry place. The PhEur 6.5 specifies that chitosan should be stored at a temperature of 2–88℃. Incompatibilities Chitosan is incompatible with strong oxidizing agents. Regulatory Status Chitosan is registered as a food supplement in some countries.   Chitosan Preparation Products And Raw materials Raw materials Sodium hydroxide-->Formaldehyde-->Acrylamide-->Polyacrylamide-->Chitin-->Amino tris(methylene phosphonic acid) Preparation Products Chitin-->drug delivery of chitosan carboxymethylcellulose complexes-->materials of oral delivery system for peptide drugs and their controlled release-->CARBOXYLATION CHITOSAN-->the gum from the chitin   Tag:Chitosan(9012-76-4) Related Product Information Product Name: Lecithin Synonyms: l-α-phosphatidylcholine solution;l-α-phosphatidylcholine, hydrogenated;LECITHIN GRANULAR G2C (EPIKURON 100G2C);LECITHIN POWDER;LECITHIN,ENZYME-MODIFIED;LECITHIN,GRANULAR,FCC;LECITHIN,GRANULAR,NF;PHOSPHATIDYLCHOLINE(LECITHIN)(RG) CAS: 8002-43-5 MF: C42H80NO8P MW: 758.06 EINECS: 232-307-2 Product Categories: Functional Products;Antioxidants;Plant extracts;Herb extract;soya protein;Organic chemistry;Food Additives Mol File: 8002-43-5.mol   Lecithin Chemical Properties Melting point  >145°C (dec.) density  d424 1.0305 Fp  57 °C storage temp.  -20°C solubility  chloroform: 0.1 g/mL, slightly hazy, slightly yellow to deep orange form  solution color  Pale Brown to Yellow Water Solubility  NEGLIGIBLE Merck  14,5429 BRN  5209585 Stability: Stable, but light, heat, moisture and air-sensitive. Incompatible with strong oxidizing agents. InChIKey FWMYJLDHIVCJCT-VSZGHEPYSA-N CAS DataBase Reference 8002-43-5 EPA Substance Registry System Lecithins (8002-43-5)   Safety Information Hazard Codes    Risk Statements    Safety Statements    WGK Germany  3 RTECS  OG7565000 F  1-8-10 TSCA  Yes HS Code  29239000 Hazardous Substances Data 8002-43-5(Hazardous Substances Data) Toxicity LD50 oral in rat: > 8mL/kg MSDS Information Provider Language Lecithin English ALFA English   Lecithin Usage And Synthesis Description Food-grade lecithin is obtained from soybeans and other plant sources. It is a complex mixture of acetone-insoluble phosphatides that consists chiefly of phosphatidyl choline, phosphatidyl etha nolamine, and phosphatidyl inositol, combined with various amounts of other substances such as triglycerides, fatty acids, and carbohydrates. Refined grades of lecithin may contain any of these components in varying proportions and combinations depending on the type of fractionation used. In its oil-free form, the prepon-derance of triglycerides and fatty acids is removed and the product contains 90% or more of phosphatides representing all or certain fractions of the total phosphatide complex. The consistency of both natural grades and refined grades of lecithin may vary from plastic to fluid, depending upon free fatty acid and oil content, and upon the presence or absence of other diluents. Its color varies from light yellow to brown, depending on the source, on crop variations, and on whether it is bleached or unbleached. It is odorless or has a characteristic, slight nutlike odor and a bland taste. Edible diluents, such as cocoa butter and vegetable oils, often replace soybean oil to improve functional and flavor characteris tics. Lecithin is only partially soluble in water, but it readily hydrates to form emulsions. The oil-free phosphatides are soluble in fatty acids, but are practically insoluble in fixed oils. When all phosphatide fractions are present, lecithin is partially soluble in alcohol and practically insoluble in acetone. Chemical Properties Lecithins vary greatly in their physical form, from viscous semiliquids to powders, depending upon the free fatty acid content. They may also vary in color from brown to light yellow, depending upon whether they are bleached or unbleached or on the degree of purity. When they are exposed to air, rapid oxidation occurs, also resulting in a dark yellow or brown color. Lecithins have practically no odor. Those derived from vegetable sources have a bland or nutlike taste, similar to that of soybean oil. Occurrence Lecithin is found in foods such as eggs, beef liver, and peanuts. Commercial sources are available Uses Edible and digestible surfactant and emulsifier of natural origin. Used in margarine, chocolate and in the food industry in general. In pharmaceuticals and cosmetics. Many other industrial uses, e.g. treating leather and textiles. Uses lecithin (hydrogenated) is an emulsifier. Uses lecithin is a natural emollient, emulsifier, anti-oxidant, and spreading agent, lecithin is a hydrophilic ingredient that attracts water and acts as a moisturizer. generally obtained for cosmetic products from eggs and soybeans, it is found in all living organisms. Uses egg lecithin is emollient and particularly recommended for sensitive skin. Uses Lecithin is an emulsifier that is a mixture of phosphatides which are typically surface-active. it is now commercially obtained from soy- beans; previously it was obtained from egg yolk. it is used in marga- rine as an emulsifier and antispatter agent; in chocolate manufacture it controls flow properties by reducing viscosity and reducing the cocoa butter content from 3 to 5%; it is used as a wetting agent in cocoa powder, fillings, and beverage powders; an antisticking agent in griddling fat; and in baked goods to assist the shortening mix with other dough ingredients and to stabilize air cells. typical usage levels range from 0.1 to 1.0%. Definition ChEBI: A glycerophosphocholine compound having O-acyl substituents at both the 1- and 2-positions of the glycerol. It is a major constituent of cell membranes. Production Methods Lecithins are essential components of cell membranes and, in principle, may be obtained from a wide variety of living matter. In practice, however, lecithins are usually obtained from vegetable products such as soybean, peanut, cottonseed, sunflower, rapeseed, corn, or groundnut oils. Soybean lecithin is the most commercially important vegetable lecithin. Lecithin obtained from eggs is also commercially important and was the first lecithin to be discovered. Vegetable lecithins are obtained as a by-product in the vegetable oil refining process. Polar lipids are extracted with hexane and, after removal of the solvent, a crude vegetable oil is obtained. Lecithin is then removed from the crude oil by water extraction. Following drying, the lecithin may be further purified. With egg lecithin, a different manufacturing process must be used since the lecithin in egg yolks is more tightly bound to proteins than in vegetable sources. Egg lecithin is thus obtained by solvent extraction from liquid egg yolks using acetone or from freeze-dried egg yolks using ethanol (95%). Synthetic lecithins may also be produced. Pharmaceutical Applications Lecithins are used in a wide variety of pharmaceutical applications. They are also used in cosmetics and food products. Lecithins are mainly used in pharmaceutical products as dispersing, emulsifying, and stabilizing agents, and are included in intramuscular and intravenous injections, parenteral nutrition formulations, and topical products such as creams and ointments. Lecithins are also used in suppository bases, to reduce the brittleness of suppositories, and have been investigated for their absorption-enhancing properties in an intranasal insulin formulation. Lecithins are also commonly used as a component of enteral and parenteral nutrition formulations. There is evidence that phosphatidylcholine (a major component of lecithin) is important as a nutritional supplement to fetal and infant development. Furthermore, choline is a required component of FDA-approved infant formulas. Other studies have indicated that lecithin can protect against alcohol cirrhosis of the liver, lower serum cholesterol levels, and improve mental and physical performance. Liposomes in which lecithin is included as a component of the bilayer have been used to encapsulate drug substances; their potential as novel delivery systems has been investigated. This application generally requires purified lecithins combined in specific proportions. Therapeutically, lecithin and derivatives have been used as a pulmonary surfactant in the treatment of neonatal respiratory distress syndrome. Biochem/physiol Actions It also acts as a source of lipid messengers/ bioactive lipids including: lysophosphatidylcholine, diacylglycerol, phosphatidic acid, lysophosphatidylcholine, arachidonic acid and platelet activating factor. Phosphatidylcholine is produced in the liver by the CDP-choline (cytidine diphosphocholine) pathway. Safety Lecithin is a component of cell membranes and is therefore consumed as a normal part of the diet. Although excessive consumption may be harmful, it is highly biocompatible and oral doses of up to 80 g daily have been used therapeutically in the treatment of tardive dyskinesia. When used in topical formulations, lecithin is generally regarded as a nonirritant and nonsensitizing material. The Cosmetic Ingredients Review Expert Panel (CIR) has reviewed lecithin and issued a tentative report revising the safe concentration of the material from 1.95% to 15.0% in rinse-off and leave-in products. They note, however, that there are insufficient data to rule on products that are likely to be inhaled. storage Lecithins decompose at extreme pH. They are also hygroscopic and subject to microbial degradation. When heated, lecithins oxidize, darken, and decompose. Temperatures of 160–180°C will cause degradation within 24 hours. Fluid or waxy lecithin grades should be stored at room temperature or above; temperatures below 10°C may cause separation. All lecithin grades should be stored in well-closed containers protected from light and oxidation. Purified solid lecithins should be stored in tightly closed containers at subfreezing temperatures. Purification Methods Lecithin from hen egg white is purified by solvent extraction and chromatography on alumina. It is suspended in H2O and kept frozen until required [Lee & Hunt J Am Chem Soc 106 7411 1984, Singleton et al. J Am Oil Chem Soc 42 53 1965]. For purification of commercial egg lecithin, see Pangborn [J Biol Chem 188 471 1951]. Incompatibilities Incompatible with esterases owing to hydrolysis. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; IM and IV injections; otic preparations; oral capsules, suspensions and tablets; rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.   Lecithin Preparation Products And Raw materials Raw materials PASSION FLOWER OIL-->SOYBEAN OIL-->ASPHALTUM-->Soy bean Isoflavone Isoflavone 10-40%-->Cholesterol-->Soy bean phospholipid-->Calcium phytate-->PartialFattyAcidEsterofGlycerine-->Vacuum drying machine Preparation Products PHOSPHOLIPIDS-->ETHYL LINOLEATE-->Soy bean phospholipid-->PHOSPHATIDYLETHANOLAMINE   Product Name: L-Tryptophan Synonyms: Trytophan (W) Solution, 100ppm;L-Tryptophan, Trp;L-Tryptophan Vetec(TM) reagent grade, >=98%;VWR SURFACE SAMPLING SPONGE WITH NE;L-TRYPTOPHAN (13C11,D8,15N2);L-Tryptophan(pharm grade);L-Trp-OH;L-Tryptophan, Animal-Free CAS: 73-22-3 MF: C11H12N2O2 MW: 204.23 EINECS: 200-795-6 Product Categories: Inhibitors;HEPTEDRINE;alpha-Amino Acids;Biochemistry;hormones;amino;Amino Acid Derivatives;Tryptophan [Trp, W];Amino Acids;Amino Acids and Derivatives;Indoles;Tryptophans;Nutritional Supplements;L-Amino Acids;Amino Acids;Amino Acids & Derivatives Mol File: 73-22-3.mol   L-Tryptophan Chemical Properties Melting point  289-290 °C (dec.)(lit.) alpha  -31.1 º (c=1, H20) Boiling point  342.72°C (rough estimate) density  1.34 refractive index  -32 ° (C=1, H2O) storage temp.  2-8°C solubility  20% NH3: 0.1 g/mL at 20 °C, clear, colorless pka 2.46(at 25℃) form  powder color  White to yellow-white PH 5.5-7.0 (10g/l, H2O, 20℃) optical activity [α]20/D 31.5±1°, c = 1% in H2O Water Solubility  11.4 g/L (25 ºC) Merck  14,9797 BRN  86197 Stability: Stable. Incompatible with strong acids, strong oxidizing agents. InChIKey QIVBCDIJIAJPQS-VIFPVBQESA-N CAS DataBase Reference 73-22-3(CAS DataBase Reference) NIST Chemistry Reference L-Tryptophan(73-22-3) EPA Substance Registry System L-Tryptophan (73-22-3)   Safety Information Hazard Codes  Xi Risk Statements  33-40-62-41-37/38-36/37/38-22 Safety Statements  24/25-36/37/39-36-26 WGK Germany  2 RTECS  YN6130000 F  8 TSCA  Yes HS Code  29339990 Hazardous Substances Data 73-22-3(Hazardous Substances Data) Toxicity LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000). MSDS Information Provider Language Indole-3-alanine English ACROS English SigmaAldrich English ALFA English   L-Tryptophan Usage And Synthesis Description As an essential amino acid, L-Tryptophan is necessary for normal growth in infants and for nitrogen balance in adults, which cannot be synthesized from more basic substances in humans and other animals, suggesting that it is obtained only by intake of tryptophan or tryptophan-containing proteins for human body, which is particularly plentiful in chocolate, oats, milk, cottage cheese, red meat, eggs, fish, poultry, sesame, almonds, buckwheat, spirulina, and peanuts, etc. It can be used as a nutritional supplement for use as an antidepressant, anxiolytic, and sleep aid. Thus, L-Tryptophan can be used for depression, anxiety, sleep apnea, premenstrual syndrome and many other problems. Besides, it can also be used in managing pain tolerance and managing weight. It works by increasing the levels of certain neurotransmitters in the brain called serotonin. People suffer from depression have an imbalance of serotonin and other brain chemicals. Thus, the increase of serotonin levels in the brain can improve symptoms of depression. L-Tryptopan serves as the precursor for the synthesis of serotonin, which is converted to serotonin in the body. As a result, the symptoms of depression and other problems are improved. Overview It is also known as α-aminoindolylpropionic acid. Appearance: white to slightly yellowish white crystal or crystalline powder. No smell; Slight bitter taste. Melting temperature: 289 ° C (decomposition); soluble in water. Applications: as food fortifier, antioxidant; also used in medicine. It is manufactured from indole aldehyde, alternatively also be synthesized from trypsin decomposition and synthesis.  Content analysis Accurately weigh about 300 mg sample and dissolve it in 3ml formic acid and 50ml glacial acetic acid; add 2 drops crystal violet test solution (TS-250), titrate with 0.1mol / L perchloric acid to the green end point or until the blue color completely disappears. Each Ml of 0.1 mol / L perchloric acid corresponds to 20.42 mg of L-tryptophan (C11H12N2O2). Application Amino acids-type drug: It can be used in amino acid infusion, being often combined with iron and vitamins. Its co-administration with VB6 can improve depression and prevention/treatment of skin disease; as a sleep sedative, it can be combined with L-dopa for the treatment of Parkinson's disease. It is carcinogenic to experimental animals; it may cause adverse reactions including nausea, anorexia and asthmas. Avoid combination with monoamine oxidase inhibitors. Nutritional supplements: Tryptophan contained in egg white protein, fish meat, corn meal and other amino acids are limited; content in cereals such as rice is also low. It can be combined with lysine, methionine and threonine for enhanced amino acids. It can be supplemented to corn product at the content of 0.02% tryptophan and 0.1% lysine, being capable of significantly improving the protein potency. References # //www.medicinenet.com/tryptophan-oral_capsule_tablet/article.htm //bodyandhealth.canada.com/drug/getdrug/apo-tryptophan # Chemical Properties White to off-white crystalline powder Chemical Properties Appearance: white crystalline powder. Odorless, slightly bitter taste; Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition). Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH). It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein. Uses adrenergic agonist Uses L-tryptophan is an essential amino acid which is necessary for normal growth in infants and for nitrogen balance in adults. It acts as a natural dietary supplement and used as an antidepressant, anxiolytic and sleep aid. It is used as a precursor to niacin, indole alkaloids and serotonin. It acts as an important intrinsic fluorescent probe, which finds to estimate the nature of microenvironment of the tryptophan. Uses tryptophan is one of the 21 amino acids comprising a protein. Tryptophan is a component of the skin’s natural moisturizing factors. Definition ChEBI: The L-enantiomer of tryptophan. Brand name Ardeytropin;Kalma;Optimax;Sedanoct. World Health Organization (WHO) L-tryptophan, an essential aminoacid and precursor of serotonin, was introduced into medicine in 1963 for the treatment of depression and sleep disorders. Its effectiveness in these conditions has, however, never been convincingly demonstrated. It is also widely used in dietary supplements, parenteral nutrition preparations and dietary products for children with phenylketonuria. In 1989, reports from the USA showed an association between the consumption of L-tryptophan containing preparations and the development of eosiniphilia-myalgia syndrome (EMS), a condition characterized by intense eosinophilia, severe muscle and joint pain, swelling of the arms and legs, skin rashes and possible fever. Some of the reported cases have been fatal. Since it is not yet clear whether L-tryptophan itself or an unidentified contaminant is the cause of the EMS, many drug regulatory authorities have suspended the marketing authorization of products containing tryptophan pending further investigation, whereas others have withdrawn these products or restricted their use. Synthesis Reference(s) The Journal of Organic Chemistry, 49, p. 3711, 1984 DOI: 10.1021/jo00194a008 General Description White powder with a flat taste. An essential amino acid; occurs in isomeric forms. Air & Water Reactions Slightly soluble in water. Reactivity Profile Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes. Fire Hazard Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible. Biochem/physiol Actions Tryptophan (Trp) is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Increased Trp availability is necessary for the regulation of mood, cognition and behaviour. It is hypothesised that L-Trp might be useful in inducing sleep in healthy adults against the normal circadian rhythm. Trp uptake by the brain depends on the plasma ratio of Trp to all of the other LNAAs (large neutral amino acids). Higher the Trp:LNAAs ratio, greater is the Trp uptake. Safety Profile Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Crystallise L-tryptophan from H2O/EtOH, wash it with anhydrous diethyl ether and dry it at room temperature in a vacuum over P2O5. It sublimes at 220-230o/0.03mm with 99% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cox & King Org Synth Coll Vol II 612 1943, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2316-2345 1961, Beilstein 22 IV 6765.]   L-Tryptophan Preparation Products And Raw materials Raw materials Anthranilic acid-->Α-PROTEIN-->Indole-->Casein-->DL-Tryptophan-->Pancreatin-->Chloroacetic anhydride-->N-Acetyl-L-tryptophan-->D(+)-Tryptophan-->L-Serine-->3-(3-Indolyl)-2-oxopropanoic acid-->H-D-TRP-OET HCL-->Nalpha-FMOC-L-Tryptophan Preparation Products DL-Tryptophan-->L-Tryptophanol-->N-[(tert-Butoxy)carbonyl]-L-tryptophan-->L-Phenylalanine-->1H-Indole-3-propanoic acid, α-amino-2,3-dihydro-2-oxo-, (αS)--->L-Tryptophan, 1-formyl- Product Name: L-Norvaline Synonyms: L-2-AMinopentanoic-d5 Acid;L-Norvaline arginase inhibitor;L-Novvaline;Norvaline| H-Nva-OH;H-Nva-OH(L-Norvaline);L(+)-Norvaline, 99% 1GR;L-Norvaline, 97+%;H-L-NORVALINE CAS: 6600-40-4 MF: C5H11NO2 MW: 117.15 EINECS: 229-543-3 Product Categories: Pyridines;amino acid;Norvaline [Nva];Amino Acids;Unusual Amino Acids;Perindopril intermediate;chiral;PROTECTED AMINO ACID & PEPTIDES;Pharmaceutical Intermediates;Amino Acids Mol File: 6600-40-4.mol   L-Norvaline Chemical Properties Melting point  >300 °C(lit.) alpha  24.5 º (c=10, 6 N HCl) Boiling point  222.9±23.0 °C(Predicted) density  1.2000 (estimate) refractive index  25 ° (C=10, 6mol/L HCl) storage temp.  Store below +30°C. solubility  48.7g/l pka 2.32(at 25℃) form  Fine Crystalline Powder color  White Water Solubility  10.5 g/100 mL (18 ºC) Merck  14,6716 BRN  1721162 CAS DataBase Reference 6600-40-4(CAS DataBase Reference) NIST Chemistry Reference L-Norvaline(6600-40-4)   Safety Information Hazard Codes  C,Xn Risk Statements  20/21/22-36/37/38 Safety Statements  24/25-37/39-26 WGK Germany  3 HS Code  29224995 MSDS Information Provider Language L(+)-2-Aminovaleric acid English ACROS English SigmaAldrich English ALFA English   L-Norvaline Usage And Synthesis Chemical Properties white to light yellow crystal powder Uses L-Norvaline is a protein amino acid used as a skin-conditioning and anti-static agent. Uses L-Norvalineis used in method for reducing misincorporation of non-canonical branched-chain Amino Acids into recombinant proteins. Definition ChEBI: A 2-aminopentanoic acid that has S-configuration. Biochem/physiol Actions L-Norvaline enhances NO production from activated macrophages. Purification Methods Crystallise norvaline from aqueous EtOH or water. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2390-2399 1961, Beilstein 4 III 1331-1333, 4 IV 128, 2629.]   L-Norvaline Preparation Products And Raw materials Preparation Products 2-OXOPENTANOIC ACID-->BOC-NVA-OH   Product Name: L-Ornithine Synonyms: (S)-2,5-Diaminovaleric acid;ORNITHINE;L-ORNITHINE;2,5-diaminopentanoic acid;(2S)-2,5-Diaminopentanoic acid;5-Amino-L-norvaline;Ornithine Phenylacetate;Arginine EP Impurity C CAS: 70-26-8 MF: C5H12N2O2 MW: 132.16 EINECS: 200-731-7 Product Categories: Inhibitors;Amino Acids;Nutritional Supplements Mol File: 70-26-8.mol   L-Ornithine Chemical Properties Melting point  140°C alpha  D25 +11.5° (c = 6.5) Boiling point  244.08°C (rough estimate) density  1.1740 (rough estimate) refractive index  1.4496 (estimate) storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C pka 1.705(at 25℃) CAS DataBase Reference 70-26-8(CAS DataBase Reference) EPA Substance Registry System L-Ornithine (70-26-8)   Safety Information Toxicity sce-hmn-lym 10 mg/L MUREAV 372,75,1996 MSDS Information   L-Ornithine Usage And Synthesis Chemical Properties Crystals from alcoholether. Soluble in water and alcohol. Uses Biochemical research; medicine. Uses hepatoprotectant, anticholesteremic Definition ChEBI: An optically active form of ornithine having L-configuration. Synthesis Reference(s) Canadian Journal of Chemistry, 31, p. 1060, 1953 DOI: 10.1139/v53-139 Safety Profile Mutation data reported. When heated to decomposition it emits toxic vapors of NOx. Purification Methods Crystallise L-ornithine from water containing 1mM EDTA (to remove metal ions). [Perrin J Chem Soc 3125 1958, Rivard Biochemical Preparations 3 97 1955, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2477-2491 1961, Beilstein 4 III 1346, 4 IV 2644.]   L-Ornithine Preparation Products And Raw materials Preparation Products Eflornithine-->Fmoc-Orn(Fmoc)-OH

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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