China Largest Manufacturer factory sales Nattokinase CAS 133876-92-3

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Nattokinase Basic information Product Name: Nattokinase Synonyms: Nattokinase;Nattoesse Haruno-Ogawa;4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic;Liposomal NATTOKINASE, NATTOKINASE NanoEmulsion, NanoActive NATTOKINASE, Oil-Soluble NATTOKINASE;4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;4-(Carboxymethyl)-2-[(1R)-1-{[N-(2,5-dichlorobenzoyl)glycyl]amino}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;Nattokinase (peptidolytic);Nattokinase fandachem CAS: 133876-92-3 MF: C20H23BCl2N2O9 MW: 517.12162 EINECS:   Product Categories:   Mol File: 133876-92-3.mol   Nattokinase Chemical Properties   Safety Information MSDS Information   Nattokinase Usage And Synthesis   Nattokinase Preparation Products And Raw materials Product Name: L-Serine Synonyms: (s)-2-amino-3-hydroxypropanoicacid;2-Amion-3-hydroxypropionicacid;alpha-Amino-beta-hydroxypropionic acid;alpha-amino-beta-hydroxypropionicacid;Propanoic acid, 2-amino-3-hydroxy-, (S)-;8-HYDROXY-L-ALANINE;L-(-)-SERINE;L-(+)-SERINE CAS: 56-45-1 MF: C3H7NO3 MW: 105.09 EINECS: 200-274-3 Product Categories: GABA/Glycine receptor;Serine [Ser, S];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Amino Acid Derivatives;Nutritional Supplements;L-Amino Acids;Amino Acids;amino;Amino acid Mol File: 56-45-1.mol   L-Serine Chemical Properties Melting point  222 °C (dec.) (lit.) alpha  15.2 º (c=10, 2N HCl) Boiling point  197.09°C (rough estimate) density  1.6 refractive index  1.4368 (estimate) Fp  150°C storage temp.  2-8°C solubility  H2O: 50 mg/mL form  powder pka 2.19(at 25℃) color  White PH 5-6 (100g/l, H2O, 20℃) optical activity [α]20/D +13.5±0.5°, c = 5% in 5 M HCl Water Solubility  250 g/L (20 ºC) λmax λ: 260 nm Amax: 0.05 λ: 280 nm Amax: 0.05 Sublimation  150 ºC Merck  14,8460 BRN  1721404 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey MTCFGRXMJLQNBG-REOHCLBHSA-N CAS DataBase Reference 56-45-1(CAS DataBase Reference) NIST Chemistry Reference L-Serine(56-45-1) EPA Substance Registry System L-Serine (56-45-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  24/25-36-26 WGK Germany  3 RTECS  VT8100000 F  3 TSCA  Yes HS Code  29225000 Hazardous Substances Data 56-45-1(Hazardous Substances Data) MSDS Information Provider Language Ser English ACROS English SigmaAldrich English ALFA English   L-Serine Usage And Synthesis Description Serine (abbreviated as Ser or S) is an amino acid with the formula HO2CCH(NH2)CH2OH. It is one of the proteinogenic amino acids. Its codons in the genetic code are UCU, UCC, UCA, UCG, AGU and AGC. By virtue of the hydroxyl group, serine is classified as a polar amino acid. L-serine is an amino acid essential for the synthesis of phosphatidylserine, which is a component of the membrane of brain cells (i.e., neurons). It can be produced in the body, including the brain, but an external supply from the diet is essential in maintaining necessary levels. Although preclinical studies suggest L-serine may inhibit inflammation in the brain, levels of L-serine in humans do not appear to be associated with dementia or cognitive decline. Because L-serine is a naturally occurring amino acid, supplementation is likely safe in moderation. Chemical Properties L-Serine is a white crystal or crystalline powder, slightly sweet taste, soluble in water and acid, insoluble in alcohol and ether. From soybeans, wine fermentation agent, dairy products, eggs, fish, lactalbumin, meat, nuts, seafood, whey, and whole grains to get. Serine is also used as a dietary supplement where it can aid improved memory function and in personal care products where it helps with the production of new skin cells. Uses L-Serine has been used in the preparation of Tris-BSAN buffer for homogenization. It has also been used for quantitative analysis of excretion of polypeptides in normal urine. Uses L-Serine is used in the synthesis of purines and pyrimidines as antibacterial/antifungal agents, as well as acting as a proteinogenic compound. Uses L-Serine is classified as a non-essential amino acid. It is used as a cell culture media component and raw material for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. Definition ChEBI: L-serine is the L-enantiomer of serine. It has a role as a human metabolite, an algal metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a serine family amino acid, a proteinogenic amino acid, a L-alpha-amino acid and a serine. It is a conjugate base of a L-serinium. It is a conjugate acid of a L-serinate. It is an enantiomer of a D-serine. It is a tautomer of a L-serine zwitterion. Production Methods Industrially , L - serine is produced by fermentation, with an estimated 100 - 1000 tonnes per year produced . In the laboratory, racemic serine can be prepared from methyl acrylate via several steps. Biotechnological Production Serine is the first amino acid produced in the 3-phosphoglycerate pathway. It is further converted to glycine and L-cysteine. Industrially L-serine can be produced by direct fermentation or by an enzymatic process from glycine. The enzymatic route developed by Mitsui reacts glycine with formaldehyde using serine hydroxymethyltransferase (SHMT). With an overexpression of SHMT in E. coli, concentrations of serine of over 300 g/L in 35 h reaction time have been reported, with a glycine conversion of[98 %. This process requires the addition of tetrahydrofolic acid to the system as a cofactor. An alternative to enzymatic production is a direct fermentation to give L-serine. Strains based on Brevibacterium flavum and C. glutamicum have been described. In both strains, the enzymes phosphoglycerate dehydrogenase (serA), phosphoserine phosphatase (serB), and phosphoserine transaminase (serC) have been overexpressed. These enzymes are involved in the biosynthesis pathway from 3-phosphoglycerate. Note that because of product inhibition by L-serine of serA, feedback-resistant mutants have been developed to increase yields. A mutant strain of B. flavum with a feedback-resistant serA* and overexpression of the serA*, serB, and serC has been reported to accumulate 35.2 g/L L-serine with a carbon yield of 32 % based on glucose. In addition it has been shown that increased yields in C. glutamicum can be obtained by deleting the L-serine degrading enzyme L-serine dehydratase (sdaA). General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Biological Activity L-Serine is an endogenous agonist at the inhibitory glycine receptor. L-Serine is a non-essential amino acid that acts as a precursor for nucleotide synthesis. It has roles in the development and function of the central nervous system. L-Serine also has a role in cellular proliferation. Precursor of glycine by serine hydroxymethyltransferase. Biochem/physiol Actions Precursor of glycine by serine hydroxymethyltransferase. Biotechnological Applications Metabolic Serine is important in metabolism in that it participates in the biosynthesis of purines and pyrimidines. It is the precursor to several amino acids including glycine and cysteine, and tryptophan in bacteria. It is also the precursor to numerous other metabolites, including sphingolipids and folate, which is the principal donor of one-carbon fragments in biosynthesis. Structural role Serine plays an important role in the catalytic function of many enzymes. It has been shown to occur in the active sites of chymotrypsin, trypsin, and many other enzymes. The so-called nerve gases and many substances used in insecticides have been shown to act by combining with a residue of serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation, which may be functionally related to diabetes. It is one of three amino acid residues that are commonly phosphorylated by kinases during cell signaling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine. Signaling D-Serine, synthesized in the brain by serine racemase from Lserine (its enantiomer), serves as both a neuro transmitter and a gliotransmitter by coactivating NMDA receptors, making them able to open if they then also bind glutamate. D-serine is a potent agonist at the glycine site of the NMDA-type glutamate receptor. For the receptor to open, glutamate and either glycine or D-serine must bind to it. In fact, D-serine is a more potent agonist at the glycine site on the NMDAR than glycine itself. D-serine was only thought to exist in bacteria until relatively recently; it was the second D amino acid discovered to naturally exist in humans, present as a signalling molecule in the brain, soon after the discovery of D-aspartate. Had D amino acids been discovered in humans sooner, the glycine site on the NMDA receptor might instead be named the D-serine site. Gustatory sensation Pure D-Serine is an off-white crystalline powder with a very faint funky or dirty aroma. L-Serine is sweet with minor umami and sour tastes at high concentration. D-Serine is sweet with an additional minor sour taste at medium and high concentrations. Safety L-serine is generally safe to take as an oral dietary supplement. In a phase 1 safety trial in 20 ALS patients, L-serine treatment (0.5-15.0 g, twice daily) for 6 months was generally well-tolerated and appeared to be safe. Two patients withdrew from the trial due to gastrointestinal side effects but no other adverse events or changes in routine blood tests measures were observed. Chemical Synthesis This compound is one of the naturally occurring proteinogenic amino acids. Only the L-stereoisomer appears naturally in proteins. It is not essential to the human diet, since it is synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865. Its name is derived from the Latin for silk, sericum. Serine's structure was established in 1902. The biosynthesis of serine starts with the oxidation of 3- phosphoglycerate to 3-phosphohydroxypyruvate and NADH. Reductive amination of this ketone followed by hydrolysis gives serine. Serine hydroxymethyltransferase catalyzes the reversible, simultaneous conversions of L-serine to glycine (retro-aldol cleavage) and 5,6,7,8-tetra hydrofolate to 5,10-methylene tetra hydrofolate (hydrolysis). This compound may also be naturally produced when UV light illuminates simple ices such as a combination of water, methanol, hydrogen cyanide, and ammonia, suggesting that it may be easily produced in cold regions of space. Purification Methods A likely impurity is glycine. Crystallise L-serine from H2O by adding 4volumes of EtOH. Dry and store it in a desiccator. It sublimes at 160-170o/0.3mm with 99.7% recovery, and unracemised [Gross & Gradsky J Am   L-Serine Preparation Products And Raw materials Raw materials Ethyl acetate-->Ammonium hydroxide-->Ethyl formate-->Chloroacetyl chloride-->Α-PROTEIN-->Polyvinyl chloride-->Boc-D-Tyr-OH-->ANION EXCHANGE RESIN 717-->DL-Serine-->Aminoacylase-->ETHYL HIPPURATE Preparation Products L-SERINE METHYL ESTER Raw materials Dicyandiamide-->Ammonium sulfamate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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