China Manufacturer factory sales Copovidone CAS 25086-89-9

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                                PRODUCT DETAILS       

 

Product Name:Copvodione

 

Chemical Description:Vinylpyrrolidone with Vinyl Acetate Copolymer,PVP/VA 64 Powder

 

INCI/CTFA:VP/VA Copolymer

 

Pharmacopeia Name:Copovidone(Copovidonum)

 

CAS NO.:25086-89-9

 

Formula structure:

        

Properties: White or creamy white,free-flowing power with characteristic smell,hygroscopic.Good solubility in water,alcohol and other organic solvents.

 

Applications:In view of it’s excellent adhesiveness ,film hard and other properties,Copovidone mainly used as water-soluble binder and dry binder in wet/direct granulation processes,also it can be used as film forming materials.

 

Specifications:

Appearance	White to creamy white,free-flowing powder
K Value(Labled K value at 30)	27-32.4
Aldehyde	500 ppm max.
Peroxide	400 ppm max.
Hydrazine	1 ppm max.
Monomers(Residue VP+Residue VA)	0.1% max.
Impurity A(2-Pyrrolidone)	0.5% max.
Heavy Metals	20 ppm max.
Moisture	5.0% max.
Sulphated Ash	0.1% max.
VA content	35.3-42% max.
Nitrogen	7.0-8.0 %

Poly(1-vinylpyrrolidone-co-vinyl acetate) Basic information Product Name: Poly(1-vinylpyrrolidone-co-vinyl acetate) Synonyms: Aceticacid,ethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylester,polymerwith1-ethenyl-2-pyrrolidinone;aceticacidethenylestercopolymerwith1-ethenyl-2-pyrrolidinone;aceticacidvinylester,polymerwith1-vinyl-2-pyrrolidinone;gantrons860;i535;i635;i735 CAS: 25086-89-9 MF: C10H15NO3 MW: 197.23 EINECS:   Product Categories: API;Hydrophobic Polymers;Polymers;Materials Science;Polymer Science;Vinylpyridine and Vinypyrrolidone Polymers;Hair Care;Hydrophobic Polymers;Poly(vinylpyrrolidone);Vinylpyridine and Vinypyrrolidone Polymers;J's Mol File: 25086-89-9.mol   Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties density  1.27 g/mL at 25 °C(lit.) refractive index  1.4300 to 1.4380 Fp  72 °F solubility  Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane. form  powder color  White Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents. EPA Substance Registry System Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)   Safety Information Hazard Codes  Xi,F Risk Statements  10-36/37/38-67-36-11-22 Safety Statements  22-24/25-36/37/39-26-16 RIDADR  UN 1987 3/PG 2 WGK Germany  1 RTECS  AH3539000 HazardClass  3 PackingGroup  II HS Code  29349990 Toxicity LD50 orl-rat: >630 mg/kg JACTDZ 2(5),141,83 MSDS Information Provider Language SigmaAldrich English   Poly(1-vinylpyrrolidone-co-vinyl acetate) Usage And Synthesis Chemical Properties white powder Chemical Properties Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste. Uses Poly(1-vinylpyrrolidone-co-vinyl acetate) Uses Copovidone is a water-soluble polymer used to improve the uptake and drug loading of various pharmaceutical agents, including contraceptive patches. Production Methods Copovidone is manufactured by free-radical polymerization of vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is conducted in an organic solvent owing to the insolubility of vinyl acetate in water. General Description ～1:2.4 mole ratio of VP:VA Pharmaceutical Applications Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations. In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier. Safety Profile Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx. Safety Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin. A study was conducted to look at the carcinogenicity and chronic toxicity of copovidone (Kollidon VA 64) in Wistar rats and Beagle dogs. The results of these studies demonstrated the absence of any significant toxicological findings of high dietary levels of copodivone in rats and dogs, resulting in noobserved- adverse-effect levels of 2800 mg/kg body-weight/day in rats and 2500 mg/kg body-weight/day in dogs, the highest doses tested. LD50 (rat, oral): >0.63 g/kg storage Copovidone is stable and should be stored in a well-closed container in a cool, dry place. Incompatibilities Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone. Regulatory Status Copovidone is included in the FDA Inactive Ingredients Database (oral tablets, oral film-coated tablets, sustained action).   Poly(1-vinylpyrrolidone-co-vinyl acetate) Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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