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Product name: Sorbic Acid Product Category: Food and Feed Additives Cas No.: 110-44-1 EINECS NO： 203-768-7 Formula: C6H8O2 Structure Formula:  M.W.： 112.13 Date of expiry: 2 years STORAGE: Preserve in tight containers protected from light at room temperature PACKAGING: Packing in 25kgs/50lbs craft bag,25kg/50lbs carton,and 750-800kgs/2000lbs super sack Characters colorless acicular crystal or white crystal powder. Tasteless, slight special smell. Melting point:132~135℃; Boiling point:228℃(resolve); Flash point: 127℃.Difficultly soluble in water(0.16g/100ml，20℃),soluble in alcohol(1g/10ml),in diethyl ether(1g/10ml),in anhydrous alcohol(12.9g/100ml),in peanut oil(0.9g/100ml),in glycerin(0.3g/100ml)and in acetic acid(11.5g/100ml)。 Main Uses: Preservative, stabilizers and antioxidants Sorbic acid is a new, safe, nontoxic and effective food preservative. It is unsaturated fatty acid. It can participate in normal metabolism and finally be oxidized to water and carbon dioxide, does not accumulate in the human body and has high safety. Its toxicity is only half of salt, 1/ 40 of sodium benzoate and has been recognized internationally as the best food additives. Sorbic acid has been approved of using in worldwide and successfully used in the food industry in many ways. It has obvious inhibition of molds, yeasts and aerobic bacteria, whose effect on inhibit the growth of bacteria is stronger than the effect on destroy bacteria. It combines with sulfhydryl group in microbial enzyme system to destroy the role of enzymes, so that achieve the purposes of bacteriostasis and antisepsis. It also can prevent from the growth and breeding of botox, staphylococcus and salmonella and other harmful microorganisms. Under acidic conditions (pH value less than 5-6), the effect of bacteriostasis is better, and the food composition has no any impact of preservative effect, so it effectively extends the storage time of food and keep the original flavor of food. However, there is no effect on anaerobic bacteria Bacillus and Lactobacillus acidophilus and other beneficial micro-organisms.

Sorbic acid Basic information Product Name: Sorbic acid Synonyms: (e,e)-4-hexadienoicacid;(E,E)-Sorbic acid;2,4-Hexadienoicacid,(E,E)-;2e,4e-hexadienoicacid;4-Hexadienoicacid,(E,E)-2;2-PROPENYL ACRYLIC ACID;1,3-Pentadiene-1-carboxylic acid;2,4-HEXANEDIENOIC ACID CAS: 110-44-1 MF: C6H8O2 MW: 112.13 EINECS: 203-768-7 Product Categories: Antibiotics by Application;Antibiotics N-S;Food and Feed Additive;Food & Feed ADDITIVES;Preservatives and Disinfectants;Antibiotics;FOOD ADDITIVES;Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives;Organic acids;Antibiotics A to Z;Antifungal;Biochemicals and Reagents;Building Blocks;C6;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Fatty Acids and conjugates;Fatty Acyls;Lipids;Organic Building Blocks;Others;Polyunsaturated;Spectrum of Activity;Unsaturated Fatty Acids and Derivatives;Food additive. Mol File: 110-44-1.mol   Sorbic acid Chemical Properties Melting point  132-135 °C (lit.) Boiling point  228°C density  1.2 g/cm3 at 20 °C vapor pressure  0.01 mm Hg ( 20 °C) FEMA  3921 | 2,4-HEXADIENOIC ACID, (E,E)- refractive index  1.4600 (estimate) Fp  127 °C storage temp.  2-8°C solubility  ethanol: 0.1 g/mL, clear pka 4.76(at 25℃) form  Crystalline Powder color  White or cream-white PH 3.3 (1.6g/l, H2O, 20°C) Water Solubility  1.6 g/L (20 ºC) JECFA Number 1176 Merck  14,8721 BRN  1741831 Stability: Stability Material saturated with this acid may ignite spontaneously. Incompatible with strong oxidizing agents. May be light sensitive. InChIKey WSWCOQWTEOXDQX-MQQKCMAXSA-N CAS DataBase Reference 110-44-1(CAS DataBase Reference) NIST Chemistry Reference 2,4-Hexadienoic acid, (E,E)-(110-44-1) EPA Substance Registry System Sorbic acid (110-44-1)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38-36/38 Safety Statements  26-36-24/25 WGK Germany  1 RTECS  WG2100000 F  8 Autoignition Temperature >130 °C TSCA  Yes HS Code  29161930 Hazardous Substances Data 110-44-1(Hazardous Substances Data) Toxicity LD50 orally in rats: 7.36 g/kg (Smyth, Carpenter) MSDS Information Provider Language Sorbic acid English SigmaAldrich English ACROS English ALFA English   Sorbic acid Usage And Synthesis Description Sorbic acid, also known as herbal tea acid, 2,4-hexadienoic acid, 2-propenyl acrylic acid, with molecular formula C6H8O2, is a food additive that has inhibitory effects on many fungi such as yeast and mold. It is also used in animal feed, cosmetics, pharmaceuticals, packaging materials and rubber additives. Chemical Properties (E,E)-2,4-Hexadienoic acid has a characteristic odor. Chemical Properties White, crystalline solid. Slightly soluble in water and many organic solvents. Combustible. History Sorbic acid is a white crystalline solid first isolated in 1859 by hydrolysis of the oil distilled from unripened mountain-ash berries. The name is derived from the scientific term for the rowan tree, Sorbus aucuparia Linne, which is the parent plant of the mountain ash. Sorbic acid was first synthesized in 1900. Interest in this compound was minimal until independent researchers, E. Mueller of Germany and C.M. Gooding of the United States, discovered its antimicrobial effect in 1939 and 1940, respectively. Early interest in manufacturing sorbic acid centered around its use as a tung oil replacement when tung oil supplies were curtailed in the United States during World War II. High manufacturing costs prohibited expanded use until its approval as a food preservative in 1953. Sorbic acid is widely used in foods having a pH of 6.5 or below, where control of bacteria, molds, and yeasts is essential for obtaining safe and economical storage life. Uses sorbic acid is a broad-spectrum, non-toxic preservative against molds and yeasts with moderate sensitizing potential in leave-on cosmetics. It is used in concentrations of 0.1 to 0.3 percent, and its activity is dependent on the formulation’s pH. Sorbic acid is used as a replacement for glycerin in emulsions, ointments, and various cosmetic creams. It is obtained from the berries of the tree commonly known as mountain ash and rowan, and can also be produced synthetically. Sorbic acid can cause irritation. Uses Sorbic Acid is a preservative that is effective against yeasts and molds. it is effective over a broad ph range up to ph 6.5, being ineffective above ph 7.0. it is a white, free-flowing powder which is slightly soluble in water with a solubility of 0.16 g in 100 ml of water at 20°c. its solubility in water increases with increasing temperatures, although it is not recommended in foods that are pasteurized because it breaks down at high temperatures. the salts are potas- sium, calcium, and sodium sorbate. it is used in cheese, jelly, bever- ages, syrup, and pickles. typical usage levels range from 0.05 to 0.10%. Uses Sorbic Acid is an naturally occurring organic compound first isolated from unripe berries. Sorbic acid has been used as a food preservative and as an inhibitor of Clostridium Botulinum bacteria in mea t products in order to reduce the amount of nitrites which produce carcinogenic nitroamines. Uses Mold and yeast inhibitor. Fungistatic agent for foods, especially cheeses. To improve the characteristics of drying oils. In alkyd type coatings to improve gloss. To improve milling characteristics of cold rubber. See also Potassium Sorbate. Definition ChEBI: A sorbic acid having trans-double bonds at positions 2 and 4; a food preservative that can induce cutaneous vasodilation and stinging upon topical application to humans. It is the most thermodynamically stable of the four possible geometri isomers possible, as well as the one with the highest antimicrobial activity. Reactions The chemical reactivity of sorbic acid is determined by the conjugated double bonds and the carboxyl group. Sorbic acid is brominated faster than other olefinic acids. Reaction with hydrogen chloride gives predominately 5-chloro-3-hexenoic acid. Reactions with amines at high temperatures under pressure lead to mixtures of dehydro-2-piperidinones. A yellow crystalline complex is formed from sorbic acid and iron tricarbonyl. Similar coordination occurs also in the presence of other di- and trivalent metals. Reduction of the double bonds can produce various hexenoic acid mixtures. Biotechnological Production Today, sorbic acid is produced solely by chemical synthesis. However, fermentation and chemical synthesis might be combined to develop a new production route for sorbic acid . In a first step, glucose would be converted to triacetic acid lactone by fermentation. It has been shown that triacetic acid lactone can be produced by genetically modified E. coli and S. cerevisiae strains. After a separation from the fermentation broth, triacetic acid lactone would be transformed into butyl sorbate in a multistage catalyst system (catalysis-hydrogenation and solid acid catalysis). Then, butyl sorbate would be purified and hydrolyzed to sorbic acid. Different scenarios are analyzed to evaluate the economic feasibility of such a production process . Synthesis Reference(s) Chemistry Letters, 10, p. 1289, 1981 Organic Syntheses, Coll. Vol. 3, p. 783, 1955 Tetrahedron Letters, 22, p. 69, 1981 DOI: 10.1016/0040-4039(81)80043-3 General Description White powder or crystals. Melting point 134.5°C. Slightly acidic and astringent taste with a faint odor. Air & Water Reactions Soluble in hot water [Handbook of Chemistry and Physics]. May be sensitive to exposure to air and heat. The dust may become explosive, particularly when mixed with free-radical initiators or oxidizing agents. . Reactivity Profile Sorbic acid may discolor on exposure to light. Can react with oxidizing agents. Also incompatible with bases and reducing agents. The dust may become explosive, particularly when mixed with free-radical initiators or oxidizing agents . Fire Hazard Sorbic acid is combustible. Biochem/physiol Actions Sorbic acid can be used to inhibit bacterial, yeast and fungal sulfhydryl enzymes by inhibiting amino acid uptake. Toxicology Sorbic acid and its salts have broad-spectrum activity against yeast and molds, but are less active against bacteria. The antimicrobial action of sorbic acid was discovered independently in the United States and Germany in 1939, and since the mid-1950s sorbates have been increasingly used as preservatives. Sorbates generally have been found superior to benzoate for preservation of margarine, fish, cheese, bread, and cake. Sorbic acid and its potassium salts are used in low concentrations to control mold and yeast growth in cheese products, some fish and meat products, fresh fruits, vegetables, fruit beverages, baked foods, pickles, and wines. Sorbic acid is practically nontoxic. Table 10.4 shows acute toxicity of sorbic acid and its potassium salt. Animal studies have not shown obvious problems in tests performed with large doses for longer time periods. When sorbic acid (40 mg/kg/day) was injected directly into the stomach of male and female mice for 20 months, no differences were observed in survival rates, growth rates, or appetite between the injected mice and the control. When the dose was increased to 80 mg/kg/day for three additional months, however, some growth inhibition was observed. When potassium sorbate (1 and 2% in feed) was fed to dogs for three months, no pathological abnormalities were observed. This evidence indicates that the subacute toxicity of sorbic acid is negligible. As a relatively new food additive, sorbate has been subject to stringent toxicity-testing requirements. It may well be the most intensively studied of all chemical food preservatives. In 90-day feeding studies in rats and dogs and a lifetime feeding study in rats, a 5% dietary level of sorbates procured no observable adverse effects. However, at a 10% dietary level in a 120- day feeding study, rats showed increased growth and increased liver weight. This has been attributed to the caloric value of sorbate at these high dietary levels since it can act as a substrate for normal catabolic metabolism in mammals. Sorbates are not mutagenic or tumorigenic, and as noted previously, no reproductive toxicity has been observed. Safety Profile Moderately toxic by intraperitoneal and subcutaneous routes. Mildly toxic by ingestion. Experimental reproductive effects. A severe human and experimental skin irritant. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use water. When heated to decomposition it emits acrid smoke and irritating fumes. Carcinogenicity Wistar rats (six males) given subcutaneous injections of 2mg sorbic acid, in 0.5mL of arachis oil twice weekly for 65 weeks developed local sarcomas . The first tumor was observed at 82 weeks. Similar findings were also observed in follow-up studies . However, six Wistar rats maintained on drinking water containing 10 mg of sorbic acid/100mL drinking water for 64 weeks did not develop tumors. Tumors also were not observed inWistar rats (50 of each sex) on diets that contained 40 mg/kg/day of sorbic acid for 18 months or in 25 male and female cross-bred white mice after administration of 40 mg/kg/day for 17 months. Mice fed a diet containing 15% sorbic acid for 88 weeks exhibited a high incidence of hepatoma. Furthermore, the glutathione level in the livers of the mice that ingested 15% sorbic acid decreased to 40% of the amount found in controls after a 3-month feeding period; this low level was maintained until the end of the experiments at 12 months. There was a close correlation between the extent of depletion of the glutathione level in the liver and the concentration of sorbic acid added to the diet. In the same strain of mice fed a diet containing 15% sorbic acid for up to 6 months, the acidic fraction of an ether extract showed slight mutagenic activity in an Ames test with Salmonella typhimurium TA98 in the presence of a liver 9000-g supernatant. Consequently, the hepatomas that developed in mice fed a 15% sorbic acid diet were considered to be induced both by the chronic depletion of the hepatic glutathione and by the gradual production of various promutagens in the intestine, which were absorbed and metabolically activated by the liver. Purification Methods Crystallise the acid from water. Dry it air or in a desiccator over P2O5. [Beilstein 2 IV 1701.]   Sorbic acid Preparation Products And Raw materials Raw materials Sodium hydroxide-->Hydrochloric acid-->Acetic acid-->Toluene-->Zinc chloride-->Malonic acid-->1,3-BUTADIENE-->Acetyl ketene-->Cobalt chloride-->Gamma Butyrolactone-->Acetaldehyde-->ketene-->Crotonaldehyde-->1-Hexene-->Manganese triacetate dihydrate-->POLYSTER RESIN-->Ethyl 3,4-dihydroxybenzoate-->glyceric acid Preparation Products Antistaling agent-->Potassium sorbate-->Potassium sorbate-->trans-2-Hexen-1-ol-->Calcium sorbate-->Sodium Sorbate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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