China Largest Manufacturer factory sales Cinnamyl alcohol CAS 104-54-1

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Cinnamyl alcohol Basic information Description Uses Preparation References Product Name: Cinnamyl alcohol Synonyms: TRANS-CINNAMYL ALCOHOL;TRANS-3-PHENYL-2-PROPEN-1-OL;3-HYDROXY-1-PHENYL-1-PROPENE;3-PHENYLPROPENOL;3-PHENYLALLYL ALCOHOL;3-PHENYLALLYLOL;3-PHENYL-2-PROPEN-1-OL;3-PHENYL-2-PROPENE-1-OL CAS: 104-54-1 MF: C9H10O MW: 134.18 EINECS: 203-212-3 Product Categories: Benzhydrols, Benzyl & Special Alcohols;Pharmaceutical Intermediates;chemical reagent;pharmaceutical intermediate;phytochemical;Cosmetics;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;104-54-1 Mol File: 104-54-1.mol   Cinnamyl alcohol Chemical Properties Melting point  30-33 °C (lit.) Boiling point  250 °C (lit.) density  1.044 g/mL at 25 °C (lit.) vapor density  4.6 (vs air) vapor pressure  <0.01 mm Hg ( 25 °C) FEMA  2294 | CINNAMYL ALCOHOL refractive index  1.5819 Fp  >230 °F storage temp.  -20°C solubility  H2O: soluble form  Fused Low Melting Crystalline Solid Specific Gravity 1.044 color  White Water Solubility  1.8 g/L (20 ºC) JECFA Number 647 Merck  14,2302 BRN  1903999 Stability: Stable. Incompatible with strong oxidizing agents. InChIKey OOCCDEMITAIZTP-QPJJXVBHSA-N CAS DataBase Reference 104-54-1(CAS DataBase Reference) NIST Chemistry Reference 2-Propen-1-ol, 3-phenyl-(104-54-1) EPA Substance Registry System 3-Phenyl-2-propen-1-ol (104-54-1)   Safety Information Hazard Codes  Xn Risk Statements  22-36/38-43-36 Safety Statements  26-36/37-37/39-24-24/25 RIDADR  2811 WGK Germany  2 RTECS  GE2200000 F  10-23 TSCA  Yes HS Code  29062990 Hazardous Substances Data 104-54-1(Hazardous Substances Data) Toxicity LD50 (g/kg): 2.0 orally in rats; >5.0 dermally in rabbits (Letizia) MSDS Information Provider Language 3-Phenyl-2-propene-1-ol English ACROS English SigmaAldrich English ALFA English   Cinnamyl alcohol Usage And Synthesis Description As an organic compound, Cinnamyl alcohol has a very distinct sweet, spicy, hyacinth odour that is found in resins, balsams and cinnamon leaves. It is used commonly in the fragrance industry due to its distinctive odour, which can be applied as a deodorant, fragrance and additive in cosmetic products and in the formulation of bath products, body and hand products, such as soaps, toothpaste, deodorants, etc. Besides, it also finds application as a food additive in chewing gum, bakery products, candy and soft drinks. Naturally, Cinnamyl alcohol is occurrent only in small amount, thus its industrial demand is usually fulfilled by chemical synthesis starting from the reduction of cinnamaldehyde. Cinnamyl alcohol has been found to have a sensitising effect on some particular people, thus it is also considered as a Standardized Chemical Allergen. The physiologic effect of cinnamyl alcohol is caused by the Increased Histamine Release and cell-mediated Immunity. Uses Cinnamyl alcohol is valuable in perfumery for its odor and fixative properties. It is a component of many flower compositions (lilac, hyacinth, and lily of the valley) and is a starting material for cinnamyl esters, several of which are valuable fragrance materials. In flavor compositions, the alcohol is used for cinnamon notes and for rounding off fruit aromas. Preparation Cinnamyl alcohol is prepared on an industrial scale by reduction of cinnamaldehyde. Three methods are particularly useful: 1) In the Meerwein–Ponndorf reduction, cinnamaldehyde is reduced to cinnamic alcohol (yield about 85%) with isopropyl or benzyl alcohol in the presence of the corresponding aluminum alcoholate. 2) A 95% yield of Cinnamyl alcohol is obtained by selective hydrogenation of the carbonyl group in cinnamaldehydewith, for example, an osmium–carbon catalyst. 3) High yields of Cinnamyl alcohol can be obtained by reduction of cinnamaldehyde with alkali borohydrides. Formation of dihydrocinnamic alcohol is thus avoided. References # //www.huidziekten.nl/allergie/stoffen/cinnamic-alcohol.htm # //www.cosmeticsinfo.org/ingredient/cinnamyl-alcohol-0 # //www.somaiya.com/products/chemicals-pipeline/cinnamic-alcohol-1 Description Occupational cases of contact dermatitis were reported in the perfurne industry. Patch tests can also be positive in food handlers. Cinnamic alcohol is contained in the "fragrance mix". Chemical Properties Cinnamyl alcohol can exist in (Z)-[4510-34-3] and (E)-[4407-36-7] forms. Although both isomers occur in nature, the (E)-isomer is far more abundant and is present, for example, in styrax oil. (E)-Cinnamyl alcohol is a colorless, crystalline solid with a hyacinth-like balsamic odor. Cinnamyl alcohol can be dehydrogenated to give cinnamaldehyde and oxidized to give cinnamic acid. Hydrogenation yields 3-phenylpropanol and/or 3-cyclohexylpropanol. Reaction with carboxylic acids or carboxylic acid derivatives results in the formation of cinnamyl esters, some of which are used as fragrance materials. Chemical Properties Cinnamyl alcohol has a pleasant, floral odor and bitter taste. Occurrence Occurring as an ester or in the free state in hyacinth, Aristolochia clematis, Xanthorrhoea hastilis and in the essence of daffodil flowers. It is also reported found in guava fruit and peel, lemon peel oil, cassia leaf, Bourbon vanilla and cinnamon bark, leaf and root. Uses Cinnamic alcohol is a component in perfumed cosmetic products and deodorants; some perfumery uses (cinnamon; daffodil; hyacinth; jasmine); natural occurrence (cinnamon). Uses cinnamyl alcohol is naturally occurring in cinnamon bark, it can also be synthetically manufactured. It is used in cosmetics as a fragrance or flavoring agent.In perfumery; as deodorant in 12.5% solution in glycerol. Uses Cinnamyl alcohol was used to study the alkylation of 2,4-di-tert-butylphenol by cinnamyl alcohol using aluminum-containing mesoporous ethane-silica catalyst. It was used to study gold nanoparticles supported on titanium dioxide catalysed oxidative coupling of alcohols and amines to form the corresponding imines. Definition ChEBI: A primary alcohol comprising an allyl core with a hydroxy substituent at the 1-position and a phenyl substituent at the 3-position (geometry of the C2C bond unspecified). Preparation By reduction of cinnamic aldehyde. Aroma threshold values Detection: 1 ppm; cis- form, 81 ppb; trans- form, 2.8 ppm Taste threshold values Taste characteristics at 20 ppm: green, floral, spicy and honey with a fermented yeasty nuance. Synthesis Reference(s) Chemistry Letters, 5, p. 581, 1976 The Journal of Organic Chemistry, 59, p. 6378, 1994 DOI: 10.1021/jo00100a046 Tetrahedron Letters, 34, p. 257, 1993 DOI: 10.1016/S0040-4039(00)60561-0 Contact allergens Cinnamyl alcohol occurs (in esterified form) in storax, Myroxylon pereirae, cinnamon leaves, and hyacinth oil. It is obtained by the alkaline hydrolysis of storax and prepared synthetically by reducing cinnamal diacetate with iron filings and acetic acid, and from cinnamaldehyde by Meerwein-Ponndorf reduction with aluminum isopropoxide. Cinnamyl alcohol is contained in the “fragrance mix.” As a fragrance allergen, it has to be mentioned by name in cosmetics within the EU. Occupational cases of contact dermatitis were reported in perfume industry. Patch tests can be positive in food handlers. Chemical Synthesis Obtained originally by saponification of extraction from storax; synthetically, by reduction of cinnamaldehyde with sodium or potassium hydroxide. Purification Methods Crystallise the alcohol from diethyl ether/pentane. [Beilstein 6 I 281.]   Cinnamyl alcohol Preparation Products And Raw materials Raw materials Sodium hydroxide-->Hydrogen-->Benzaldehyde-->trans-Cinnamic acid-->Aluminium isopropoxide-->trans-Cinnamaldehyde-->Cinnamaldehyde-->CINNAMIC ALCOHOL-->Cinnamyl cinnamate-->Cinnamon oil-->Peru balsam-->STYRAX Preparation Products Chloramphenicol-->Flunarizine dihydrochloride-->Cinnamyl acetate-->Clofibrate-->Cinnamyl bromide-->A-METHYL-N-(3-PHENYL-2-PROPENYL)BENZNEETHANAMINE-->(3-methoxy-1-propenyl)benzene-->Cyclopropanemethanol, 2,2-dichloro-3-phenyl--->CINNAMONITRILE-->Flunarizine-->DIPHENYLCYCLOPROPENONE-->Phenylpropyl aldehyde

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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