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2-Phenoxyethanol Basic information Product Name: 2-Phenoxyethanol Synonyms: Ethylene Glycol Monophenyl Ether Phenyl Cellosolve Phenyl Glycol;ETHYLENE GLYCOL MONOPHENYL ETHER FOR SYN;(2-Hydroxyethoxy)benzene;PhG;Protectol PE;ACETONITRILE ACS GRADE;beta-Phenoxyethanol;beta-phenoxyethanol[qr] CAS: 122-99-6 MF: C8H10O2 MW: 138.16 EINECS: 204-589-7 Product Categories: Imidazoles ,Heterocyclic Acids;Organic Building Blocks;Benzhydrols, Benzyl & Special Alcohols;Ethylene Glycols & Monofunctional Ethylene Glycols;Oxygen Compounds;Polymer Science;Monofunctional Ethylene Glycols;Hydrophobic Polymers;Propylene Glycol Oligomers;Alcohols;Building Blocks;C7 to C8;Chemical Synthesis;Ethers;Materials Science Mol File: 122-99-6.mol   2-Phenoxyethanol Chemical Properties Melting point  11-13 °C (lit.) Boiling point  247 °C (lit.) density  1.102 g/mL at 25 °C (lit.) vapor density  4.8 (vs air) vapor pressure  0.01 mm Hg ( 20 °C) FEMA  4620 | 2-PHENOXYETHANOL refractive index  n20/D 1.539 Fp  >230 °F storage temp.  Store below +30°C. solubility  soluble, clear, colorless to very faintly yellow form  Liquid pka 14.36±0.10(Predicted) color  Clear colorless Specific Gravity 1.109 (20/4℃) Odor Faint aromatic odor PH 7 (10g/l, H2O, 23℃) PH Range 7 at 10 g/l at 23 °C explosive limit 1.4-9.0%(V) Water Solubility  30 g/L (20 ºC) Merck  14,7257 BRN  1364011 InChIKey QCDWFXQBSFUVSP-UHFFFAOYSA-N CAS DataBase Reference 122-99-6(CAS DataBase Reference) NIST Chemistry Reference 2-Phenoxyethanol(122-99-6) EPA Substance Registry System Ethylene glycol monophenyl ether (122-99-6)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36-R36-R22 Safety Statements  26-S26 WGK Germany  1 RTECS  KM0350000 Autoignition Temperature 535 °C DIN 51794 Hazard Note  Irritant TSCA  Yes HS Code  29094990 Hazardous Substances Data 122-99-6(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg MSDS Information Provider Language Ethylene glycol monophenyl ether English SigmaAldrich English ACROS English ALFA English   2-Phenoxyethanol Usage And Synthesis Description Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative. Chemical Properties clear colorless liquid Chemical Properties Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste. Characteristics Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances. Uses phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol. Uses Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products. Uses Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile. Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative. Uses Antimicrobial preservative; also used topically in treatment of bacterial infections. Production Methods Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium. Synthesis Reference(s) The Journal of Organic Chemistry, 40, p. 1356, 1975 DOI: 10.1021/jo00897a043 General Description Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant. Air & Water Reactions Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble. Reactivity Profile 2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides. Health Hazard May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis. Fire Hazard 2-Phenoxyethanol is combustible. Pharmaceutical Applications Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes. Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives, Industrial uses 2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%. 2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives. 2-Phenoxyethanol is not registered as a food additive in the EU. Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day). Contact allergens Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl K 400) or with parabens. Sensitization to this molecule is very rare. Safety Profile Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS. Safety Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics. The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants. LD50 (rabbit, skin): 5 g/kg LD50 (rat, oral): 1.26 g/kg storage Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place. Incompatibilities The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)). Regulatory Status Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients. Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.   2-Phenoxyethanol Preparation Products And Raw materials Raw materials ETHYLENE OXIDE-->2-Fluoroethanol-->Sodium benzenolate-->Ethyl phenoxyacetate-->2-Iodoethanol-->2-Bromoethanol-->Phenol-->Methyl phenoxyacetate-->Ethylene carbonate-->2-Chloroethanol-->Phenoxyacetic acid Preparation Products Pyriproxyfen-->impregnanting agent for leather-->bis(2-phenoxyethyl) peroxydicarbonate-->Phenoxyethyl isobutyrate-->CORTEX ALDEHYDE 50 BENZYL ALCOHOL-->1,4-Benzodioxan-->2-(2,4-DICHLOROPHENOXY)ETHANOL-->2-(4-aminophenoxy)ethanol

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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