China Largest Manufacturer factory Supply 4-Hydroxycoumarin CAS 1076-38-6

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4-Hydroxycoumarin Basic information Product Name: 4-Hydroxycoumarin Synonyms: 4-hydroxy-2h-1-benzopyran-2-on;COUMARINOL;HYDROXYCOUMARIN, 4-;2H-1-BENZOPYRAN-2-ONE, 4-HYDROXY-;4-coumarinyl alcohol;4-HYDROXY-CHROMEN-2-ONE;4-HYDROXYCOUMARIN;4-HYDROXYCUMARIN CAS: 1076-38-6 MF: C9H6O3 MW: 162.14 EINECS: 214-060-2 Product Categories: Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;Cell Biology;Chemical Synthesis;H;FINE Chemical & INTERMEDIATES;Coumarins;Coumarin;Heterocyclic Building Blocks;Luminescent Compounds/Detection;Wavelength Index;Pharmaceutical intermediates Mol File: 1076-38-6.mol   4-Hydroxycoumarin Chemical Properties Melting point  211-213 °C (lit.) Boiling point  228.82°C (rough estimate) density  1.1734 (rough estimate) refractive index  1.4500 (estimate) storage temp.  Store below +30°C. solubility  DMSO (Slightly), Methanol (Slightly) pka 4.50±1.00(Predicted) form  Liquid color  Clear colorless to slightly yellow Water Solubility  PRACTICALLY INSOLUBLE BRN  129768 InChIKey VXIXUWQIVKSKSA-UHFFFAOYSA-N CAS DataBase Reference 1076-38-6(CAS DataBase Reference) NIST Chemistry Reference 4-Hydroxycoumarin(1076-38-6) EPA Substance Registry System 2H-1-Benzopyran-2-one, 4-hydroxy- (1076-38-6)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38 Safety Statements  26-36 WGK Germany  3 RTECS  DJ3100000 Hazard Note  Irritant TSCA  Yes HS Code  29322980 MSDS Information Provider Language 4-Hydroxy-1-benzopyran-2-one English SigmaAldrich English ACROS English ALFA English   4-Hydroxycoumarin Usage And Synthesis Chemical Properties Yellow powder or chunks or Slightly yellow needle-like crystals.  freely soluble in ethanol, ether and hot water. brown in color with ferric chloride. Uses 4-Hydroxycoumarin is a plant derived antioxidant, protecting against lipid peroxidation, as well as a potential inhibitor of HIV-1 Integrase. 4-Hydroxycoumarins are a very important class of biologically active drugs which are widely used as anticoagulants-Warfarin and Acenocoumarol. Uses 4-Hydroxycoumarin may be regarded as a phenylenetetronic acid , and like tetronic acid forms condensation products with aldehydes. Synthesis of biscoumarin derivatives by the reaction of aldehydes and 4-hydroxycoumarin using ruthenium(III) chloride hydrate as a versatile homogeneous catalyst. Uses 4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans. Definition ChEBI: 4-hydroxycoumarin is a hydroxycoumarin that is coumarin in which the hydrogen at position 4 is replaced by a hydroxy group. It is a conjugate acid of a 4-hydroxycoumarin(1-). Synthesis Reference(s) The Journal of Organic Chemistry, 25, p. 677, 1960 DOI: 10.1021/jo01074a630 Purification Methods Crystallise 4-hydroxycoumarin from water and dry it in a vacuum desiccator over pKEst Sicapent. [Beilstein 18/1 V 378.]   4-Hydroxycoumarin Preparation Products And Raw materials Raw materials Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Sodium sulfate-->Benzene-->Sodium hydride-->Sodium acetate-->Mineral oil-->Diethyl carbonate-->2'-Hydroxyacetophenone-->Acetoxyacetic acid-->O-ACETYLSALICYLOYL CHLORIDE-->ACETYLSALICYLIC ACID METHYL ESTER Preparation Products Warfarin-->Bromadiolone-->Brodifacoum-->p-Coumaric acid-->Flocoumafen-->Coumatetralyl-->ACENOCOUMAROL-->reversible temperature indication paint (III)-->4-HYDROXY-2-OXO-2H-CHROMENE-3-CARBALDEHYDE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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