China Largest Manufacturer factory Supply 1-Hexadecanol CAS 36653-82-4

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1-Hexadecanol Basic information Product Name: 1-Hexadecanol Synonyms: Adol 52;Adol 52 NF;Adol 520;Adol 54;adol52;adol520;adol52nf;adol54 CAS: 36653-82-4 MF: C16H34O MW: 242.44 EINECS: 253-149-0 Product Categories: Inhibitors;Alcohols;Building Blocks;C11 to C30+;Chemical Synthesis;Organic Building Blocks;1-Alkanols;Biochemistry;Higher Fatty Acids & Higher Alcohols;Monofunctional & alpha,omega-Bifunctional Alkanes;Monofunctional Alkanes;Saturated Higher Alcohols;Oxygen Compounds;36653-82-4 Mol File: 36653-82-4.mol   1-Hexadecanol Chemical Properties Melting point  48-50 °C (lit.) Boiling point  179-181 °C/10 mmHg (lit.) density  0.818 g/mL at 25 °C (lit.) vapor density  8.34 (vs air) vapor pressure  <0.01 mm Hg ( 43 °C) refractive index  nD79 1.4283 FEMA  2554 | 1-HEXADECANOL Fp  275 °F storage temp.  Store below +30°C. solubility  Soluble in alcohol, chloroform, ether form  Powder, Flakes or Pellets pka 15.20±0.10(Predicted) color  White to off-white explosive limit 8% Water Solubility  insoluble Merck  14,2028 JECFA Number 114 BRN  1748475 Stability: Stable. Incompatible with strong oxidizing agents, strong acids. CAS DataBase Reference 36653-82-4(CAS DataBase Reference) NIST Chemistry Reference 1-Hexadecanol(36653-82-4) EPA Substance Registry System 1-Hexadecanol (36653-82-4)   Safety Information Hazard Codes  Xi Risk Statements  38-36/37/38 Safety Statements  22-24/25-37 WGK Germany  - RTECS  MM0225000 Autoignition Temperature 483 °F TSCA  Yes HS Code  29051700 Hazardous Substances Data 36653-82-4(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg MSDS Information Provider Language ACROS English SigmaAldrich English ALFA English   1-Hexadecanol Usage And Synthesis Description 1-Hexadecanol is odorless. It is used as cosmetic ingredient, emollient, foam stabilizer. It is also used as the raw material for the manufacture of surfactants, Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuffs. Chemical Properties Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste. Originator Hexadecyl alcohol,Esso Res. And Eng. Co. Occurrence Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw Uses 1-Hexadecanol has been used in preparation of: (±)-2-methoxyheptadecanoic acid (fatty acid) high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1 Uses cetyl alcohol is a versatile ingredient that can serve as an emollient, emulsifier, thickener, binder, foam booster, or emulsion stabilizer, depending on the formulation and need. It is derived from coconut or palm oil as well as being synthetically manufactured. It is considered by some sources to be a non-comedogenic material. Definition ChEBI: A long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. Production Methods Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation. Therapeutic Function Pharmaceutic aid Synthesis Reference(s) The Journal of Organic Chemistry, 42, p. 512, 1977 DOI: 10.1021/jo00423a025 Synthetic Communications, 25, p. 1901, 1995 DOI: 10.1080/00397919508015865 Tetrahedron Letters, 24, p. 4485, 1983 DOI: 10.1016/S0040-4039(00)85933-X General Description Cetyl alcohol is a long chain alcohol, which can find applications as an emulsifying agent, emollient, viscosity increasing agent, foam booster and opacifying agent in pharmaceuticals and cosmetics. Safety Cetyl alcohol is mainly used in topical formulations, although it has also been used in oral and rectal preparations. Cetyl alcohol has been associated with allergic delayed-type hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization with cetostearyl alcohol, lanolin, and stearyl alcohol has also been reported. It has been suggested that hypersensitivity may be caused by impurities in commercial grades of cetyl alcohol since highly refined cetyl alcohol (99.5%) has not been associated with hypersensitivity reactions. LD50 (mouse, IP): 1.6 g/kg LD50 (mouse, oral): 3.2 g/kg LD50 (rat, IP): 1.6 g/kg LD50 (rat, oral): 5 g/kg storage Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place. Purification Methods Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.] Incompatibilities Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals. Regulatory Status Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.   1-Hexadecanol Preparation Products And Raw materials Raw materials Sodium hydroxide-->Sodium borohydride-->Detergent-->Palmitoyl chloride-->CETYL PALMITATE-->Sodium bicarbonate-->Hydrochloric acid-->Calcium oxide-->16-HENTRIACONTANONE Preparation Products Hexadecyl trimethyl ammonium bromide-->1-Bromohexadecane-->STEARYL TARTRATE-->Miltefosine-->1-IODOHEXADECANE-->1-Chlorohexadecane-->CETYL LACTATE-->2-Hexanone, 4-hydroxy- (6CI,9CI)-->2-HEXADECANOL-->Palmityl myristate-->N-HEXADECYL SULFIDE-->cetyl myristoleate

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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