China Largest Manufacturer factory Supply BENZOPHENONE-3 CAS 131-57-7

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Oxybenzone Basic information description Chemical properties Application and Synthesis Improvement of UV - 9 Production Process Product Name: Oxybenzone Synonyms: component of Presun 29;component of Presun 30;Cyasorb uv 9;Cyasorb uv 9 light absorber;cyasorbuv9;Escalol 567;Eusolex 4360;Lankromark LE296 CAS: 131-57-7 MF: C14H12O3 MW: 228.24 EINECS: 205-031-5 Product Categories: UVINUL M40;Aromatic Benzophenones & Derivatives (substituted);Industrial/Fine Chemicals;Additives for Plastic;Organics Mol File: 131-57-7.mol   Oxybenzone Chemical Properties Melting point  62-64 °C(lit.) Boiling point  150-160 °C5 mm Hg(lit.) density  1,3 g/cm3 refractive index  1.5805 (estimate) Fp  216°C storage temp.  2-8°C solubility  95% ethanol: soluble50mg/mL, clear, colorless form  Crystalline Powder pka 7.56±0.35(Predicted) color  White to light yellow Water Solubility  <0.1 g/100 mL at 20 ºC Merck  14,6954 BRN  1913145 InChIKey DXGLGDHPHMLXJC-UHFFFAOYSA-N CAS DataBase Reference 131-57-7(CAS DataBase Reference) NIST Chemistry Reference Oxybenzone(131-57-7) EPA Substance Registry System 2-Hydroxy-4-methoxybenzophenone (131-57-7)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-37 RIDADR  UN 3077 9/PG III WGK Germany  2 RTECS  DJ1575000 TSCA  Yes HazardClass  9 PackingGroup  III HS Code  29145000 Hazardous Substances Data 131-57-7(Hazardous Substances Data) Toxicity LD50 orally in rats: >12.8 g/kg (Lewerenz) MSDS Information Provider Language 2-Hydroxy-4-methoxybenzophenone English SigmaAldrich English ACROS English ALFA English   Oxybenzone Usage And Synthesis description Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents. It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays. Oxybenzone absorbs UVB and UVA II rays, resulting in a photochemical excitation and absorption of energy. Upon return to ground state, the absorbed energy results in emission of longer wavelength radiation and decreased skin penetration of radiation which reduces the risk of DNA damage. Chemical properties light yellow crystalline powder, soluble in ethanol, acetone and other organic solvents, insoluble in water. Application and Synthesis UV-9 is a light yellow or white crystalline powder, also known as sunscreen 2, BP-3, suitable for polyvinyl chloride, polyvinylidene chloride, polymethyl methacrylate , unsaturated polyester, ABS resin and cellulose resin and other plastics, the maximum absorption wavelength range of 280-340 nm, the general amount of 0.1-1.5%, good thermal stability, does not decompose at 200 ℃. This product hardly absorb visible light, it applies to light-colored transparent products. This product can also be used for paints and synthetic rubber. For the broad-spectrum UV absorbers, with high absorption rate, non-toxic, non-teratogenic effect, light, thermal stability. UV-9 can absorb UV-A and UV-B together, is the US FDA approved Class I sunscreen and being used with a higher frequency in the US and European countries. UV-9 is widely used in sunscreen cream, cream, honey, lotion, oil and other sunscreen cosmetics, but also as a product from the photosensitive and discoloration of the anti-discoloration agent. In addition, it is usually used for PVC and unsaturated polyester and many other fields, because UV-9 has good compatibility with many kinds of plastics and resins. Improvement of UV - 9 Production Process Using mixed acid as catalyst, trichloromethylbenzene and resorcinol were condensed into intermediate 2,4-dihydroxydiphenyl ketone in aqueous phase, and then the catalyst was treated with phase transfer catalyst, etherification of the target product UV-9. Chemical Properties white to light yellow crystalline powder Uses ultraviolet screen Uses Oxybenzone is an organic compound used in sunscreens. Oxybenzone is used as an ingredient in sunscreen and other cosmetics because it absorbs UVB and short-wave UVA (ultraviolet) rays. Oxybenzone was one of the first compounds incorporated into sunscreen formulations to offer enhanced UVA protection because its absorption spectrum extends to less than 350 nm. Uses Sunscreen. UV stabilizer Uses Ultraviolet light absorber and stabilizer, especially in plastics and paints. Uses oxybenzone (benzophenone-3) is the drug name for an FDAapproved uV filter and absorber. Uses benzophenone-3 (oxybenzone) is an oil-soluble uV absorber and filter with absorption rates within the uVA and uVB peak ranges. It has an approved usage level of up to 6 percent in the united States and 10 percent in the european union. Benzophenone-3 enhances SPF and is popular among sunscreen formulators given a concern over potential safety problems associated with more traditional sunscreen chemicals. However, some reports associate it with causing photocontact allergy. It is considered a non-comedogenic raw material. Preparation Preparation by partial methylation of 2,4- dihydroxy-benzophenone, with methyl iodide in the presence of sodium hydroxide; with a methyl halide; with dimethyl sulfate in the presence of sodium hydroxide or alkaline solution. Definition ChEBI: A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively. Brand name Uvinul M40 (BASF). Synthesis Reference(s) Tetrahedron, 42, p. 885, 1986 DOI: 10.1016/S0040-4020(01)87495-0 General Description White to off-white or light yellow powder. Air & Water Reactions Insoluble in water. Fire Hazard Flash point data for Oxybenzone are not available; however, Oxybenzone is probably combustible. Contact allergens BZP-3 is used as a direct sunscreen agent and in antiaging creams. Allergic reactions have been reported. Cross-reactivity is expected in an average of one in four patients photoallergic to ketoprofen. Safety Profile Poison by intraperitoneal route. Mddly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.   Oxybenzone Preparation Products And Raw materials Raw materials Dimethyl sulfate-->Benzoyl chloride-->2,4-Dimethoxybenzophenone-->3-FORMYL-7-METHOXYCHROMONE-->Benzenemethanol, 2-hydroxy-4-methoxy-α-phenyl--->3-METHOXYPHENYLBENZOATE-->2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid-->Benzoylformic acid-->Phenylboronic acid-->3-Methoxyphenol-->2-Hydroxy-4-methoxybenzaldehyde-->2,4-Dihydroxybenzophenone-->Dimethoxybenzene Preparation Products photosensitive polyimide/SiO2 hybrid mate materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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