China Largest Manufacturer factory Supply 2,2',4,4'-TETRAHYDROXYBENZOPHENONE/BP-2 CAS 131-55-5

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2,2',4,4'-Tetrahydroxybenzophenone Basic information Application Potential Exposure & Risk Product Name: 2,2',4,4'-Tetrahydroxybenzophenone Synonyms: 2,2,4,4-Tetrahydroxybenzophenol;2,2’,4,4’-tetrahydroxy-benzophenon;2,2’,4,4’-tetrehydroxybenzophenone;2,2,4,4 TETRAHYDROXY BENZOPHENONE;2,4,2',4'-Tetrahydroxybenzophenone;2,4,2’,4’-tetrahydroxybenzophenone;Benzophenone, 2,2',4,4'-tetrahydroxy-;bis(2,4-dihydroxyphenyl)-methanon CAS: 131-55-5 MF: C13H10O5 MW: 246.22 EINECS: 205-028-9 Product Categories: Building Blocks;C13 to C14;Aromatic Benzophenones & Derivatives (substituted);Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Industrial/Fine Chemicals;Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research;C13 to C14;Carbonyl Compounds;Ketones;Pyridines ,Halogenated Heterocycles Mol File: 131-55-5.mol   2,2',4,4'-Tetrahydroxybenzophenone Chemical Properties Melting point  198-200 °C(lit.) Boiling point  349.21°C (rough estimate) density  1.216 refractive index  1.4825 (estimate) storage temp.  Sealed in dry,Room Temperature solubility  DMSO (Slightly, Sonicated), Methanol (Slightly) form  Solid pka 6.98±0.35(Predicted) color  Needles from H2O Water Solubility  Slightly soluble in water. BRN  1914746 InChIKey WXNRYSGJLQFHBR-UHFFFAOYSA-N CAS DataBase Reference 131-55-5(CAS DataBase Reference) NIST Chemistry Reference 2,2',4,4'-Tetrahydroxybenzophenone(131-55-5) EPA Substance Registry System 2,2',4,4'-Tetrahydroxybenzophenone (131-55-5)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38 Safety Statements  26-36-37/39 WGK Germany  3 RTECS  DJ1892000 TSCA  Yes HS Code  29145090 Hazardous Substances Data 131-55-5(Hazardous Substances Data) Toxicity LD50 oral in rat: 1220mg/kg MSDS Information Provider Language 2,2',4,4'-Tetrahydroxybenzophenone English SigmaAldrich English ACROS English ALFA English   2,2',4,4'-Tetrahydroxybenzophenone Usage And Synthesis Application 2,2',4,4'-Tetrahydroxybenzophenone (BZP-2) is water-soluble and light-yellow powder (figure 1). BZP-2 is widely used in perfumes to prevent their degradation due to light. BZP-2 is a UV-absorber that helps protect against product degradation because of UV-light exposure and it is widely used in sunscreens and in cosmetics (figure 2), such as: anti-aging” creams and hair sprays and shampoos, paints and plastics. It can also mask odor associated with a formulation’s composition. In addition, the hypolipemiant drug fenofibrate is also a substituted benzophenone. Potential Exposure & Risk Although 2,2',4,4'-Tetrahydroxybenzophenone is used as a UV-blocker in cosmetics, plastics and automotive car products, its safety issue still should be noted. Such as workers that use BZP-2 may breathe in dust or have direct skin contact and the general population may be exposed by dermal contact with products containing this compound. Skin allergic reaction has been reported in some people using sunscreens or cosmetics containing this compound. 2,2',4,4'-Tetrahydroxybenzophenone(BZP-2) is a member of a group of chemicals known as endocrine disruptors, which may alter the function and/or development of the reproductive system. Limited evidence indicates that exposure to benzophenone UV-absorbing chemicals, including BZP-2, is associated with an altered ratio of males to females at birth (increased females). Chemical Properties yellow to brown crystalline powder Uses 2,2′,4,4′-Tetrahydroxybenzophenone are benzophenone-type UV filters with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation. Uses 2,2',4,4'-Tetrahydroxybenzophenone is a uV-absorber that helps protect against product degradation because of uV-light exposure. It can also mask odor associated with a formulation’s composition. Uses 2,2',4,4'-Tetrahydroxybenzophenone is used as the raw material of ultraviolet absorbers in cosmetics, plastics, resins and rubber. It is used as pharmaceutical intermediates and light-sensitive materials. It is also used as pharmaceutical adjuvant. Preparation Obtained (small amount) by melting a fluorescin chloride/sodium hydroxide mixture in the presence of a very few water at 230–240° for 2–3 h. Contact allergens BZP-2 is widely used in perfumes to prevent their degradation due to light. It can cause allergic contact dermatitis. Safety Profile Moderately toxic by ingestion. Aneye irritant. Mutation data reported. When heated todecomposition it emits toxic fumes of NOx.   2,2',4,4'-Tetrahydroxybenzophenone Preparation Products And Raw materials Preparation Products 3,6-Dimethoxyxanthone

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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