China Largest Manufacturer factory Supply L-Tryptophan CAS 73-22-3

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L-Tryptophan Basic information Description Overview Content analysis Application References Product Name: L-Tryptophan Synonyms: Trytophan (W) Solution, 100ppm;L-Tryptophan, Trp;L-Tryptophan Vetec(TM) reagent grade, >=98%;VWR SURFACE SAMPLING SPONGE WITH NE;L-TRYPTOPHAN (13C11,D8,15N2);L-Tryptophan(pharm grade);L-Trp-OH;L-Tryptophan, Animal-Free CAS: 73-22-3 MF: C11H12N2O2 MW: 204.23 EINECS: 200-795-6 Product Categories: Inhibitors;HEPTEDRINE;alpha-Amino Acids;Biochemistry;hormones;amino;Amino Acid Derivatives;Tryptophan [Trp, W];Amino Acids;Amino Acids and Derivatives;Indoles;Tryptophans;Nutritional Supplements;L-Amino Acids;Amino Acids;Amino Acids & Derivatives Mol File: 73-22-3.mol   L-Tryptophan Chemical Properties Melting point  289-290 °C (dec.)(lit.) alpha  -31.1 º (c=1, H20) Boiling point  342.72°C (rough estimate) density  1.34 refractive index  -32 ° (C=1, H2O) storage temp.  2-8°C solubility  20% NH3: 0.1 g/mL at 20 °C, clear, colorless form  powder pka 2.46(at 25℃) color  White to yellow-white PH 5.5-7.0 (10g/l, H2O, 20℃) optical activity [α]20/D 31.5±1°, c = 1% in H2O Water Solubility  11.4 g/L (25 ºC) Merck  14,9797 BRN  86197 Stability: Stable. Incompatible with strong acids, strong oxidizing agents. InChIKey QIVBCDIJIAJPQS-VIFPVBQESA-N CAS DataBase Reference 73-22-3(CAS DataBase Reference) NIST Chemistry Reference L-Tryptophan(73-22-3) EPA Substance Registry System L-Tryptophan (73-22-3)   Safety Information Hazard Codes  Xi Risk Statements  33-40-62-41-37/38-36/37/38-22 Safety Statements  24/25-36/37/39-36-26 WGK Germany  2 RTECS  YN6130000 F  8 TSCA  Yes HS Code  29339990 Hazardous Substances Data 73-22-3(Hazardous Substances Data) Toxicity LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000). MSDS Information Provider Language Indole-3-alanine English ACROS English SigmaAldrich English ALFA English   L-Tryptophan Usage And Synthesis Description As an essential amino acid, L-Tryptophan is necessary for normal growth in infants and for nitrogen balance in adults, which cannot be synthesized from more basic substances in humans and other animals, suggesting that it is obtained only by intake of tryptophan or tryptophan-containing proteins for human body, which is particularly plentiful in chocolate, oats, milk, cottage cheese, red meat, eggs, fish, poultry, sesame, almonds, buckwheat, spirulina, and peanuts, etc. It can be used as a nutritional supplement for use as an antidepressant, anxiolytic, and sleep aid. Thus, L-Tryptophan can be used for depression, anxiety, sleep apnea, premenstrual syndrome and many other problems. Besides, it can also be used in managing pain tolerance and managing weight. It works by increasing the levels of certain neurotransmitters in the brain called serotonin. People suffer from depression have an imbalance of serotonin and other brain chemicals. Thus, the increase of serotonin levels in the brain can improve symptoms of depression. L-Tryptopan serves as the precursor for the synthesis of serotonin, which is converted to serotonin in the body. As a result, the symptoms of depression and other problems are improved. Overview It is also known as α-aminoindolylpropionic acid. Appearance: white to slightly yellowish white crystal or crystalline powder. No smell; Slight bitter taste. Melting temperature: 289 ° C (decomposition); soluble in water. Applications: as food fortifier, antioxidant; also used in medicine. It is manufactured from indole aldehyde, alternatively also be synthesized from trypsin decomposition and synthesis.  Content analysis Accurately weigh about 300 mg sample and dissolve it in 3ml formic acid and 50ml glacial acetic acid; add 2 drops crystal violet test solution (TS-250), titrate with 0.1mol / L perchloric acid to the green end point or until the blue color completely disappears. Each Ml of 0.1 mol / L perchloric acid corresponds to 20.42 mg of L-tryptophan (C11H12N2O2). Application Amino acids-type drug: It can be used in amino acid infusion, being often combined with iron and vitamins. Its co-administration with VB6 can improve depression and prevention/treatment of skin disease; as a sleep sedative, it can be combined with L-dopa for the treatment of Parkinson's disease. It is carcinogenic to experimental animals; it may cause adverse reactions including nausea, anorexia and asthmas. Avoid combination with monoamine oxidase inhibitors. Nutritional supplements: Tryptophan contained in egg white protein, fish meat, corn meal and other amino acids are limited; content in cereals such as rice is also low. It can be combined with lysine, methionine and threonine for enhanced amino acids. It can be supplemented to corn product at the content of 0.02% tryptophan and 0.1% lysine, being capable of significantly improving the protein potency. References # //www.medicinenet.com/tryptophan-oral_capsule_tablet/article.htm //bodyandhealth.canada.com/drug/getdrug/apo-tryptophan # Chemical Properties White to off-white crystalline powder Chemical Properties Appearance: white crystalline powder. Odorless, slightly bitter taste; Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition). Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH). It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein. Uses adrenergic agonist Uses L-tryptophan is an essential amino acid which is necessary for normal growth in infants and for nitrogen balance in adults. It acts as a natural dietary supplement and used as an antidepressant, anxiolytic and sleep aid. It is used as a precursor to niacin, indole alkaloids and serotonin. It acts as an important intrinsic fluorescent probe, which finds to estimate the nature of microenvironment of the tryptophan. Uses tryptophan is one of the 21 amino acids comprising a protein. Tryptophan is a component of the skin’s natural moisturizing factors. Definition ChEBI: The L-enantiomer of tryptophan. Brand name Ardeytropin;Kalma;Optimax;Sedanoct. World Health Organization (WHO) L-tryptophan, an essential aminoacid and precursor of serotonin, was introduced into medicine in 1963 for the treatment of depression and sleep disorders. Its effectiveness in these conditions has, however, never been convincingly demonstrated. It is also widely used in dietary supplements, parenteral nutrition preparations and dietary products for children with phenylketonuria. In 1989, reports from the USA showed an association between the consumption of L-tryptophan containing preparations and the development of eosiniphilia-myalgia syndrome (EMS), a condition characterized by intense eosinophilia, severe muscle and joint pain, swelling of the arms and legs, skin rashes and possible fever. Some of the reported cases have been fatal. Since it is not yet clear whether L-tryptophan itself or an unidentified contaminant is the cause of the EMS, many drug regulatory authorities have suspended the marketing authorization of products containing tryptophan pending further investigation, whereas others have withdrawn these products or restricted their use. Synthesis Reference(s) The Journal of Organic Chemistry, 49, p. 3711, 1984 DOI: 10.1021/jo00194a008 General Description White powder with a flat taste. An essential amino acid; occurs in isomeric forms. Air & Water Reactions Slightly soluble in water. Reactivity Profile Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Health Hazard ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes. Fire Hazard Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible. Biochem/physiol Actions Tryptophan (Trp) is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Increased Trp availability is necessary for the regulation of mood, cognition and behaviour. It is hypothesised that L-Trp might be useful in inducing sleep in healthy adults against the normal circadian rhythm. Trp uptake by the brain depends on the plasma ratio of Trp to all of the other LNAAs (large neutral amino acids). Higher the Trp:LNAAs ratio, greater is the Trp uptake. Safety Profile Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx. Purification Methods Crystallise L-tryptophan from H2O/EtOH, wash it with anhydrous diethyl ether and dry it at room temperature in a vacuum over P2O5. It sublimes at 220-230o/0.03mm with 99% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cox & King Org Synth Coll Vol II 612 1943, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2316-2345 1961, Beilstein 22 IV 6765.]   L-Tryptophan Preparation Products And Raw materials Raw materials Anthranilic acid-->Α-PROTEIN-->Indole-->Casein-->DL-Tryptophan-->Pancreatin-->Chloroacetic anhydride-->N-Acetyl-L-tryptophan-->D(+)-Tryptophan-->L-Serine-->3-(3-Indolyl)-2-oxopropanoic acid-->H-D-TRP-OET HCL-->Nalpha-FMOC-L-Tryptophan Preparation Products DL-Tryptophan-->L-Tryptophanol-->N-[(tert-Butoxy)carbonyl]-L-tryptophan-->L-Phenylalanine-->1H-Indole-3-propanoic acid, α-amino-2,3-dihydro-2-oxo-, (αS)--->L-Tryptophan, 1-formyl-

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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