China Largest Manufacturer factory Supply 3,5-Diiodo-L-tyrosine dihydrate CAS 300-39-0

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3,5-Diiodo-L-tyrosine dihydrate Basic information Product Name: 3,5-Diiodo-L-tyrosine dihydrate Synonyms: 3,5-Diiodo-L-tyrosine dihydrate, BR;Liothyronine EP Impurity B;3,5-Diiodo-4-hydroxy-β-phenylalanine;3,5-diiodo-l-tyrosin;3,5-Diiodotyrocine;3,5-Iodo-L-tyrosine;3,5-L-Diiodotyrosine;4-Hydroxy-3,5-diiodophenylalanine CAS: 300-39-0 MF: C9H9I2NO3 MW: 432.98 EINECS: 206-092-0 Product Categories: Pharmaceutical Raw Materials;Amino Acids;Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids Mol File: 300-39-0.mol   3,5-Diiodo-L-tyrosine dihydrate Chemical Properties Melting point  200 °C (dec.)(lit.) alpha  -20.7 º (c=2.5, 0.1N NaOH/H2O) Boiling point  546.5°C (rough estimate) density  2.405±0.06 g/cm3(Predicted) refractive index  1.2 ° (C=5, 1mol/L HCl) storage temp.  2-8°C solubility  Aqueous Acid (Slightly), DMSO (Slightly) pka 2.12(at 25℃) form  crystalline color  white Water Solubility  slightly soluble Sensitive  Light Sensitive CAS DataBase Reference 300-39-0(CAS DataBase Reference) NIST Chemistry Reference 3,5-Diiodo-l-tyrosine(300-39-0) EPA Substance Registry System L-Tyrosine, 3,5-diiodo- (300-39-0)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-37/39-36/37-24/25 RIDADR  2811 WGK Germany  3 F  8 TSCA  Yes HS Code  29225090 MSDS Information Provider Language 3,5-Diiodo-L-tyrosine dihydrate English SigmaAldrich English   3,5-Diiodo-L-tyrosine dihydrate Usage And Synthesis Description Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity. Chemical Properties white to beige powder Uses It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity. Uses 3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity. Uses 3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist. Definition ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis. Chemical Synthesis Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide. Purification Methods It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]   3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials Raw materials L-Tyrosine-->Ammonia-->Iodine Preparation Products L-Thyroxine-->3-IODO-L-TYROSINE-->N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester-->4-Hydroxyphenylacetamide

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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