China Largest Manufacturer factory Supply Dehydroacetic acid CAS 520-45-6

Superiority:

                                PRODUCT DETAILS       

Dehydroacetic acid Basic information Product Name: Dehydroacetic acid Synonyms: 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione. enol form;3-acetyl-6-methyl-2h-pyran-2,4(3h)-dione.enolform;3-acetyl-6-methyl-2h-pyran-2,4(3h)-dioneenolform;3-acetyl-6-methyl-2h-pyran-4(3h)-dione;3-Acetyl-6-Methyldihydropyrandione-2,4;3-Acetyl-6-methylpyrandione-2,4;4(3H)-dione,3-acetyl-6-methyl-2H-Pyran-2;4-Hexenoic acid, 2-acetyl-5-hydroxy-3-oxo-, delta-lactone CAS: 520-45-6 MF: C8H8O4 MW: 168.15 EINECS: 208-293-9 Product Categories: DHA;Dehydroacetic acid and derivatives;Diketene Derivatives;Miscellaneous Specialties Mol File: 520-45-6.mol   Dehydroacetic acid Chemical Properties Melting point  111-113 °C (lit.) Boiling point  270 °C (lit.) density  1.1816 (rough estimate) vapor pressure  0.001 hPa (20 °C) refractive index  1.4611 (estimate) Fp  157°C storage temp.  Store below +30°C. solubility  2g/l form  Fine Crystalline Powder pka 5.53±0.40(Predicted) color  Light yellow or cream PH 4 (2g/l, H2O, 20℃) Merck  14,2865 BRN  6129 Stability: Stable. Incompatible with oxidizing agents, bases, reducing agents. InChIKey PGRHXDWITVMQBC-UHFFFAOYSA-N CAS DataBase Reference 520-45-6(CAS DataBase Reference) NIST Chemistry Reference Dehydroacetic Acid(520-45-6) EPA Substance Registry System 3-Acetyl-6-methyl-2H-pyran-2,4(3H)-dione (520-45-6)   Safety Information Hazard Codes  Xn Risk Statements  22 Safety Statements  22-26 WGK Germany  1 RTECS  UP8050000 Autoignition Temperature 336 °C TSCA  Yes HS Code  29322980 Hazardous Substances Data 520-45-6(Hazardous Substances Data) Toxicity LD50 orally in rats: 1000 mg/kg (Spencer) MSDS Information Provider Language DHA English ACROS English SigmaAldrich English ALFA English   Dehydroacetic acid Usage And Synthesis Chemical Properties Dehydroacetic acid is a white to cream-coloured powder that is only very slightly soluble in water (less than 0.1 %). However, the sodium salt hydrate (CSH7Na04.H20) has a solubility of 33% in water at 25°C, and 48% in propylene glycol. The acid is 22% soluble in acetone, 18% in benzene, and I g dissolves in about 35 ml of ethanol.It is used to reduce pickle bloating, and as a pesticide and preservative for squash and strawberries. Its permissible use level is 65ppm. Dehydroacetic acid is one of the food additives found in red wine and was determined by ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS). To assay dehydroacetic acid, add 500 mg to a 250-ml Erlenmeyer flask and dissolve in 75 ml of neutral alcohol. Following the addition of phenolphthalein T.S., titrate with 0.1 N NaOH to a pink end-point that persists for at least 30 s. Each ml of 0.1 N NaOH = 16.82 mg of dehydroacetic acid (National Academy of Sciences, 1963). Dehydroacetic acid is a synthetic chemical (no plant-based preservatives that meet our efficacy standards currently exist) that is considered to be a low hazard for human health and for the environment. Uses Dehydroacetic acid (DHS) is used as stabilizer for cosmetic and pharmaceutical products due to its fungicide and bactericide activity, as additive for PVC-stabilizers and for the syntheses of veterinary medicines. Product Data Sheet Uses Geogard(R) 111a preservative is based on dehydroacetic acid (DHA) and therefore are recognized by major cosmetic, toiletry and fragrance regulatory authorities worldwide for use in cosmetic and personal care products. Uses Geogard(R) 221 preservative is based on dehydroacetic acid (DHA) and benzyl alcohol, and therefore is recognized by major cosmetic, toiletry and fragrance regulatory authorities worldwide for use in cosmetic and personal care products. Uses Geogard(R) 361 preservative is based on six synergistic components, all with wide global regulatory acceptance: dehydroacetic acid (DHA); salicylic acid; benzoic acid; phenoxyethanol; benzyl alcohol; and benzethonium chloride. Uses antifungal, antibacterial Uses dehydroacetic acid is a preservative with low sensitizing potential. This is a weak acid used as a fungi-and bacteria-destroying agent in cosmetics. The presence of organic matter decreases its effective ness. It is not irritating or allergy causing when applied on the skin. Uses Dehydroacetic Acid (DHA) is a preservative that is a crystalline powder with a solubility of less than 0.1 g in 100 g of water at 25°C. It can undergo a variety of chemical reactions which give it utility in many applications. It is used at 0.01–0.5% for microbiological growth inhibition in various foods. It is used for cut or peeled squash, with no more than 65 ppm remaining in or on the prepared squash. Synthesis Reference(s) The Journal of Organic Chemistry, 49, p. 5105, 1984 DOI: 10.1021/jo00200a018 General Description Dehydroacetic acid is a pyrone derivative, that is typically synthesized by the base-catalyzed dimerization of diketene. It is used as a preservative in pharmaceutical, food and cosmetic products. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Safety Profile Poison by ingestion. Moderately toxic by intraperitoneal route. Questionable carcinogen with experimental tumorigenic data. Combustible when exposed to heat or flame. When heated to decomposition it emits acrid smoke and irritating fumes.   Dehydroacetic acid Preparation Products And Raw materials Raw materials Sodium hydroxide-->Hydrochloric acid-->Toluene-->Triethylamine-->Benzene-->Ethyl acetoacetate-->Sodium ethoxide-->Acetyl ketene-->Triethylenediamine-->Polymerization inhibitor-->FISH OIL-->Pemoline-->4H-1,3-Oxazin-4-one, 2,3-dihydro-6-methyl-2-thioxo- Preparation Products Sodium dehydroacetate-->Clopidol-->4-Hydroxy-6-methyl-2-pyrone-->2,6-Dimethyl-4H-pyran-4-one

                                                                         About US 

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                      Our Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse