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China Largest Manufacturer factory Supply Yohimbe HCl CAS 146-48-5
China Largest Manufacturer factory Supply Yohimbe HCl CAS 146-48-5
China Largest Manufacturer factory Supply Yohimbe HCl CAS 146-48-5
China Largest Manufacturer factory Supply Yohimbe HCl CAS 146-48-5
China Largest Manufacturer factory Supply Yohimbe HCl CAS 146-48-5

China Largest Manufacturer factory Supply Yohimbe HCl CAS 146-48-5

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500 Kilogram

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Yohimbe HCl Yohimbe HCl 146-48-5

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  • Appearance:white powder
  • Application:Pharm chemicals industry
  • PackAge:25KG/Drum
  • ProductionCapacity:20|Metric Ton|Month
  • Storage:2-8°C
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                                PRODUCT DETAILS       

Yohimbine Basic information
Overview Information Effectiveness Side Effects
Product Name: Yohimbine
Synonyms: yohimbine;YOHIMBINE, C-;17alpha-Hydroxyyohimban-16alpha-carboxylic acid;17-alpha-hydroxy-yohimban-16-alpha-carboxylicacimethylester;17-Hydroxyyohimban-16-carboxylic acid methyl ester;17-hydroxyyohimban-16-carboxylicacidmethylester;Aphrodine;Aphrosol
CAS: 146-48-5
MF: C21H26N2O3
MW: 354.44
EINECS: 205-672-0
Product Categories: Adrenoceptor;Plant extracts;API
Mol File: 146-48-5.mol
Yohimbine Structure
 
Yohimbine Chemical Properties
Melting point  231-233 °C(lit.)
alpha  D20 +50.9 to +62.2° (ethanol); D20 +108° (pyridine); 20546 +129° (c = 0.5 in pyridine)
Boiling point  487.66°C (rough estimate)
density  1.1640 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  THF; DMSO; Chloroform;
form  Solid
pka 14.39±0.40(Predicted)
color  Beige
CAS DataBase Reference 146-48-5(CAS DataBase Reference)
NIST Chemistry Reference Yohimbine(146-48-5)
 
Safety Information
Hazard Codes  T
Risk Statements  23/24/25-39
Safety Statements  27-36/37/39-45
RIDADR  1544
RTECS  ZG1000000
HazardClass  6.1(a)
PackingGroup  II
MSDS Information
 
Yohimbine Usage And Synthesis
Overview Information

Yohimbe is the name of an evergreen tree found in parts of central and western Africa. The bark of yohimbe contains a chemical called yohimbine, which is used to make medicine. Yohimbine hydrochloride (Aphrodyne, Yocon) is a form of yohimbine that is a prescription drug in the US.
Yohimbe supplements often list yohimbe bark extract or yohimbine as the active ingredient. However, some of these products might not provide accurate information about the amount of yohimbine in the supplement. Also, some yohimbe supplements list yohimbine hydrochloride as an active ingredient. Yohimbe products containing man-made yohimbine hydrochloride as an ingredient are not legal to sell as a dietary supplement in the US.


Yohimbe is taken by mouth arouse sexual excitement, for erectile dysfunction (ED), sexual problems caused by medications for depression called selective-serotonin reuptake inhibitors (SSRIs), and general sexual problems in both men and women. It is also used for athletic performance, weight loss, exhaustion, chest pain, high blood pressure, low blood pressure that occurs when standing up, diabetic nerve pain, and for depression along with certain other medications.

Effectiveness

Anxiety. There is mixed evidence about the effectiveness of yohimbine, the active ingredient in yohimbe, for treating anxiety related to phobias. Some research suggests that it does not improve anxiety when combined with therapy. However, other research suggests that it reduces fear related to certain phobias.
Depression. Early research suggests that taking yohimbine, the active ingredient of yohimbe, daily for 10 days does not improve depression symptoms.
Erectile dysfunction (ED). There is evidence that yohimbine, the active ingredient of yohimbe, can be helpful for ED. Some herbalists suggest that the yohimbe bark actually works better than the yohimbine ingredient alone. However, so far yohimbe bark has not been evaluated in research studies.
Exercise performance. Early research suggests that taking yohimbine, the active ingredient in yohimbe, daily for 21 days does not improve exercise performance or build muscle mass in soccer players.
Head rush (orthostatic hypotension). Early research suggests that taking a single dose of yohimbine, the active ingredient in yohimbe, increases blood pressure in people with a head rush due to low blood pressure. However, other early research suggests that it does not improve blood pressure.
Sexual problems caused by selective-serotonin reuptake inhibitors (SSRIs). There is evidence from many studies that yohimbine, the active ingredient of yohimbe, can improve sexual problems associated with this class of medications used for depression. However, this benefit has not been described specifically for the yohimbe bark.
Dry mouth. Early research suggests that taking yohimbine, the active ingredient in yohimbe, improves symptoms of dry mouth in people taking antidepressants. The effect of the yohimbe bark on dry mouth is not clear.

Side Effects

Yohimbe, taken by mouth, is POSSIBLY UNSAFE. Yohimbe has been linked to reports of severe side effects including irregular or rapid heart beat, kidney failure, seizure, heart attack, and others.
The primary active ingredient in yohimbe is a drug called yohimbine. This is considered a prescription drug in North America. This drug can be safely used short-term when monitored by a health professional.
However, it is not appropriate for unsupervised use due to potentially serious side effects that it can cause.
Children should not take yohimbe. It is POSSIBLY UNSAFE for children because children appear to be extra sensitive to the harmful effects of yohimbe.
When taken by mouth in typical doses, yohimbe and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.
Taking high doses can also cause other severe problems, including difficulty breathing, paralysis, very low blood pressure, heart problems, and death. After taking a one-day dose of yohimbine, one person reported an allergic reaction involving fever; chills; listlessness; itchy, scaly skin; progressive kidney failure; and symptoms that looked like the auto-immune disease called lupus.

Description Yohimbine is a natural alkaloid. It was first extracted from the barks of Corynanthe yohimbe, a species of Rubiaceae trees in West Africa. It was reported that, in the dried bark of Pausinystalia johimbe, the content of mixed alkaloids is higher than 6.1%, in which the main component is yohimbine, indicating a great prospect for development . Yohimbe bark has been used as an aphrodisiac in Africa since ancient times. In 1900, it was applied by Kowit and Muller to patients with impotence and paralytic insensitivity caused by neurasthenia and obtained curative effect. From then on, clinical application of yohimbine began. Currently, yohimbine is a pure plant preparation in the treatment of erectile dysfunction with more affirmation and more applications.
Chemical Properties Glistening, needle-like alkaloid, soluble in alcohol and ether, very slightly soluble in water.
Physical properties Appearance: white powder. Solubility: soluble in ethanol, chloroform, and hot benzene; slightly soluble in water and ether, usually salified by hydrochloric acid to increase its solubility in water. Specific rotatory power (°): D22 +105° (in water). Melting point: 241–246 °C.
History Yohimbine has been used as an aphrodisiac for many years. At first, pharmacologists attributed its aphrodisiac effects to psychological effects similar to placebo or increasement of peripheral vascular congestion, rather than real sexual stimulation. Physiologists at the Stanford University first conducted a study on the pharmacological effects of yohimbine and found that yohimbine could increase the mating ability of rats , which was then published on Science in 1984 . In addition, researchers in the Queensland University in Canada conducted experiments on 23 patients with sexual dysfunction. Six of them recovered after taking the drug for 10 weeks. In 1987, Canadian scientists confirmed that yohimbine treatment in psychogenic impotence was safe and effective and this drug could restore the patient’ssexual ability . Besides, they proved that this medicine showed good curative effects on organic impotence.
Uses Yohimbine occurs in Corinanthe johimbeK. and Rubiaceae trees. It is also foundin the roots of Rauwolfia serpentina L.and Apocyanaceae. Its derivatives areused therapeutically as adrenergic blockingagents.
Uses sexual dysfunction
Uses Obtained from leaves and bark of Corynanthe johimbe. Formerly used as an aphrodisiac in veterinary medicine, yohimbine works primarily by acting as an antagonist at α2-adrenergic receptors.
Definition ChEBI: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.
Indications This product is listed in the 2017 edition of the British Pharmacopoeia, 40 editions of the American Pharmacopoeia, and 9.0 edition of the European Pharmacopoeia. The main clinical application of yohimbine includes tablets and injections. It is mainly used to treat various types of impotence and sexual dysfunction in men.
General Description Yohimbine (Yocon)is a competitive and selective 2-blocker. The compound isan indolealkylamine alkaloid and is found in the bark of thetree Pausinystalia yohimbe and in Rauwolfia root.
Health Hazard Pharmacologically, yohimbine is an adrenergic blocking agent. It exhibits hypotensive and cardiostimulant activities. Poisoningfrom excessive doses may become severe,causing convulsions and respiratory failure
LD50 value, intraperitoneal (mice): 16 mg/kg
LD50 value, oral (mice): 37 mg/kg.
Biological Activity α 2 -adrenoceptor antagonist (pK i values are 8.52, 8.00 and 9.17 for human a 2A , a 2B and a 2C receptors respectively).
Pharmacology Studies have shown that yohimbine has extensive pharmacological effects and has been developed for the clinical treatment of arteriosclerosis, rheumatism, and other diseases. The most obvious pharmacological action is in the treatment of male sexual dysfunction. Yohimbine tablets have been approved by the FDA and circulate in international markets. Yohimbine can selectively block the presynaptic alpha 2 receptors and promote the release of norepinephrine . It stimulates more norepinephrine released by cavernous nerve endings and reduces reflux of phallic vein, which is conducive to congestive erection. A small amount of application can make the perineum swell and stimulate the erection center at the spinal cord, leading to sexual hyperfunction . Yohimbine hydrochloride also has a psychological stimulant effect and increases libido. Like other types of adrenergic blocking drugs, yohimbine’s resistance to adrenergic mediator in blood circulation is much stronger than to sympathetic nerve impulse. Again, like tolazoline, yohimbine shows slight effect in resisting adrenergic response in ocular smooth muscle. This drug does not block the frequency and inotropic effects of epinephrine on mammalian hearts. Yohimbine has minor direct effects on smooth muscle, and its effect on the central nervous system is far less than that of ergot alkaloids, because yohimbine performs an excited-to-paralyzed action. This drug produces diuretic effect, probably due to the stimulation of the hypothalamus, resulting in release of posterior pituitary hormone. In addition, yohimbine has a significant local anesthetic effect .
Clinical Use Yohimbine increases heart rate and blood pressure as aresult of its blockade of 2-receptors in the CNS. It has beenused experimentally to treat male erectile impotence.
Purification Methods Crystallise the alkaloid from EtOH, and dry it in a vacuum to remove EtOH of crystallisation. [Van Tamelen et al. J Am Chem Soc 91 7315 1969, Stork
 
Yohimbine Preparation Products And Raw materials



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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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                                                       Product information

Yohimbine Basic information
Overview Information Effectiveness Side Effects
Product Name: Yohimbine
Synonyms: yohimbine;YOHIMBINE, C-;17alpha-Hydroxyyohimban-16alpha-carboxylic acid;17-alpha-hydroxy-yohimban-16-alpha-carboxylicacimethylester;17-Hydroxyyohimban-16-carboxylic acid methyl ester;17-hydroxyyohimban-16-carboxylicacidmethylester;Aphrodine;Aphrosol
CAS: 146-48-5
MF: C21H26N2O3
MW: 354.44
EINECS: 205-672-0
Product Categories: Adrenoceptor;Plant extracts;API
Mol File: 146-48-5.mol
Yohimbine Structure
 
Yohimbine Chemical Properties
Melting point  231-233 °C(lit.)
alpha  D20 +50.9 to +62.2° (ethanol); D20 +108° (pyridine); 20546 +129° (c = 0.5 in pyridine)
Boiling point  487.66°C (rough estimate)
density  1.1640 (rough estimate)
refractive index  1.6500 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  THF; DMSO; Chloroform;
form  Solid
pka 14.39±0.40(Predicted)
color  Beige
CAS DataBase Reference 146-48-5(CAS DataBase Reference)
NIST Chemistry Reference Yohimbine(146-48-5)
 
Safety Information
Hazard Codes  T
Risk Statements  23/24/25-39
Safety Statements  27-36/37/39-45
RIDADR  1544
RTECS  ZG1000000
HazardClass  6.1(a)
PackingGroup  II
MSDS Information
 
Yohimbine Usage And Synthesis
Overview Information

Yohimbe is the name of an evergreen tree found in parts of central and western Africa. The bark of yohimbe contains a chemical called yohimbine, which is used to make medicine. Yohimbine hydrochloride (Aphrodyne, Yocon) is a form of yohimbine that is a prescription drug in the US.
Yohimbe supplements often list yohimbe bark extract or yohimbine as the active ingredient. However, some of these products might not provide accurate information about the amount of yohimbine in the supplement. Also, some yohimbe supplements list yohimbine hydrochloride as an active ingredient. Yohimbe products containing man-made yohimbine hydrochloride as an ingredient are not legal to sell as a dietary supplement in the US.


Yohimbe is taken by mouth arouse sexual excitement, for erectile dysfunction (ED), sexual problems caused by medications for depression called selective-serotonin reuptake inhibitors (SSRIs), and general sexual problems in both men and women. It is also used for athletic performance, weight loss, exhaustion, chest pain, high blood pressure, low blood pressure that occurs when standing up, diabetic nerve pain, and for depression along with certain other medications.

Effectiveness

Anxiety. There is mixed evidence about the effectiveness of yohimbine, the active ingredient in yohimbe, for treating anxiety related to phobias. Some research suggests that it does not improve anxiety when combined with therapy. However, other research suggests that it reduces fear related to certain phobias.
Depression. Early research suggests that taking yohimbine, the active ingredient of yohimbe, daily for 10 days does not improve depression symptoms.
Erectile dysfunction (ED). There is evidence that yohimbine, the active ingredient of yohimbe, can be helpful for ED. Some herbalists suggest that the yohimbe bark actually works better than the yohimbine ingredient alone. However, so far yohimbe bark has not been evaluated in research studies.
Exercise performance. Early research suggests that taking yohimbine, the active ingredient in yohimbe, daily for 21 days does not improve exercise performance or build muscle mass in soccer players.
Head rush (orthostatic hypotension). Early research suggests that taking a single dose of yohimbine, the active ingredient in yohimbe, increases blood pressure in people with a head rush due to low blood pressure. However, other early research suggests that it does not improve blood pressure.
Sexual problems caused by selective-serotonin reuptake inhibitors (SSRIs). There is evidence from many studies that yohimbine, the active ingredient of yohimbe, can improve sexual problems associated with this class of medications used for depression. However, this benefit has not been described specifically for the yohimbe bark.
Dry mouth. Early research suggests that taking yohimbine, the active ingredient in yohimbe, improves symptoms of dry mouth in people taking antidepressants. The effect of the yohimbe bark on dry mouth is not clear.

Side Effects

Yohimbe, taken by mouth, is POSSIBLY UNSAFE. Yohimbe has been linked to reports of severe side effects including irregular or rapid heart beat, kidney failure, seizure, heart attack, and others.
The primary active ingredient in yohimbe is a drug called yohimbine. This is considered a prescription drug in North America. This drug can be safely used short-term when monitored by a health professional.
However, it is not appropriate for unsupervised use due to potentially serious side effects that it can cause.
Children should not take yohimbe. It is POSSIBLY UNSAFE for children because children appear to be extra sensitive to the harmful effects of yohimbe.
When taken by mouth in typical doses, yohimbe and the ingredient yohimbine can cause stomach upset, excitation, tremor, sleep problems, anxiety or agitation, high blood pressure, a racing heartbeat, dizziness, stomach problems, drooling, sinus pain, irritability, headache, frequent urination, bloating, rash, nausea, and vomiting.
Taking high doses can also cause other severe problems, including difficulty breathing, paralysis, very low blood pressure, heart problems, and death. After taking a one-day dose of yohimbine, one person reported an allergic reaction involving fever; chills; listlessness; itchy, scaly skin; progressive kidney failure; and symptoms that looked like the auto-immune disease called lupus.

Description Yohimbine is a natural alkaloid. It was first extracted from the barks of Corynanthe yohimbe, a species of Rubiaceae trees in West Africa. It was reported that, in the dried bark of Pausinystalia johimbe, the content of mixed alkaloids is higher than 6.1%, in which the main component is yohimbine, indicating a great prospect for development . Yohimbe bark has been used as an aphrodisiac in Africa since ancient times. In 1900, it was applied by Kowit and Muller to patients with impotence and paralytic insensitivity caused by neurasthenia and obtained curative effect. From then on, clinical application of yohimbine began. Currently, yohimbine is a pure plant preparation in the treatment of erectile dysfunction with more affirmation and more applications.
Chemical Properties Glistening, needle-like alkaloid, soluble in alcohol and ether, very slightly soluble in water.
Physical properties Appearance: white powder. Solubility: soluble in ethanol, chloroform, and hot benzene; slightly soluble in water and ether, usually salified by hydrochloric acid to increase its solubility in water. Specific rotatory power (°): D22 +105° (in water). Melting point: 241–246 °C.
History Yohimbine has been used as an aphrodisiac for many years. At first, pharmacologists attributed its aphrodisiac effects to psychological effects similar to placebo or increasement of peripheral vascular congestion, rather than real sexual stimulation. Physiologists at the Stanford University first conducted a study on the pharmacological effects of yohimbine and found that yohimbine could increase the mating ability of rats , which was then published on Science in 1984 . In addition, researchers in the Queensland University in Canada conducted experiments on 23 patients with sexual dysfunction. Six of them recovered after taking the drug for 10 weeks. In 1987, Canadian scientists confirmed that yohimbine treatment in psychogenic impotence was safe and effective and this drug could restore the patient’ssexual ability . Besides, they proved that this medicine showed good curative effects on organic impotence.
Uses Yohimbine occurs in Corinanthe johimbeK. and Rubiaceae trees. It is also foundin the roots of Rauwolfia serpentina L.and Apocyanaceae. Its derivatives areused therapeutically as adrenergic blockingagents.
Uses sexual dysfunction
Uses Obtained from leaves and bark of Corynanthe johimbe. Formerly used as an aphrodisiac in veterinary medicine, yohimbine works primarily by acting as an antagonist at α2-adrenergic receptors.
Definition ChEBI: An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.
Indications This product is listed in the 2017 edition of the British Pharmacopoeia, 40 editions of the American Pharmacopoeia, and 9.0 edition of the European Pharmacopoeia. The main clinical application of yohimbine includes tablets and injections. It is mainly used to treat various types of impotence and sexual dysfunction in men.
General Description Yohimbine (Yocon)is a competitive and selective 2-blocker. The compound isan indolealkylamine alkaloid and is found in the bark of thetree Pausinystalia yohimbe and in Rauwolfia root.
Health Hazard Pharmacologically, yohimbine is an adrenergic blocking agent. It exhibits hypotensive and cardiostimulant activities. Poisoningfrom excessive doses may become severe,causing convulsions and respiratory failure
LD50 value, intraperitoneal (mice): 16 mg/kg
LD50 value, oral (mice): 37 mg/kg.
Biological Activity α 2 -adrenoceptor antagonist (pK i values are 8.52, 8.00 and 9.17 for human a 2A , a 2B and a 2C receptors respectively).
Pharmacology Studies have shown that yohimbine has extensive pharmacological effects and has been developed for the clinical treatment of arteriosclerosis, rheumatism, and other diseases. The most obvious pharmacological action is in the treatment of male sexual dysfunction. Yohimbine tablets have been approved by the FDA and circulate in international markets. Yohimbine can selectively block the presynaptic alpha 2 receptors and promote the release of norepinephrine . It stimulates more norepinephrine released by cavernous nerve endings and reduces reflux of phallic vein, which is conducive to congestive erection. A small amount of application can make the perineum swell and stimulate the erection center at the spinal cord, leading to sexual hyperfunction . Yohimbine hydrochloride also has a psychological stimulant effect and increases libido. Like other types of adrenergic blocking drugs, yohimbine’s resistance to adrenergic mediator in blood circulation is much stronger than to sympathetic nerve impulse. Again, like tolazoline, yohimbine shows slight effect in resisting adrenergic response in ocular smooth muscle. This drug does not block the frequency and inotropic effects of epinephrine on mammalian hearts. Yohimbine has minor direct effects on smooth muscle, and its effect on the central nervous system is far less than that of ergot alkaloids, because yohimbine performs an excited-to-paralyzed action. This drug produces diuretic effect, probably due to the stimulation of the hypothalamus, resulting in release of posterior pituitary hormone. In addition, yohimbine has a significant local anesthetic effect .
Clinical Use Yohimbine increases heart rate and blood pressure as aresult of its blockade of 2-receptors in the CNS. It has beenused experimentally to treat male erectile impotence.
Purification Methods Crystallise the alkaloid from EtOH, and dry it in a vacuum to remove EtOH of crystallisation. [Van Tamelen et al. J Am Chem Soc 91 7315 1969, Stork
 
Yohimbine Preparation Products And Raw materials

 

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