China Largest Manufacturer factory sales Thiamine CAS 59-43-8

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Thiamine chloride Basic information Product Name: Thiamine chloride Synonyms: THIAMIMEMONOCHLORIDE;VITAMIN B1(THIAMINE)(BASF)(SH);VITAMIN B1(THIAMINE)(SH);Antiberiberi factor;Betamin;Beta-Sol;Biamine;Metatone CAS: 59-43-8 MF: C12H17ClN4OS MW: 300.81 EINECS: 200-425-3 Product Categories: vitamin series;Nutritional Supplements;Vitamins and Derivatives;Vitamin Ingredients Mol File: 59-43-8.mol   Thiamine chloride Chemical Properties Melting point  248 °C (decomp) density  1.3175 (rough estimate) refractive index  1.5630 (estimate) storage temp.  Keep in dark place,Inert atmosphere,Room temperature CAS DataBase Reference 59-43-8(CAS DataBase Reference) EPA Substance Registry System Thiamine (59-43-8)   Safety Information Hazardous Substances Data 59-43-8(Hazardous Substances Data) MSDS Information Provider Language Thiamine chloride English   Thiamine chloride Usage And Synthesis Originator Thiamine chloride,Sopharma Uses Vitamin B1 is used in method for cultivating tremella strain. Also, it is protein compound liquid comprising collagen and Rhodiola rosea extract or preparing injection to remove skin wrinkle. Manufacturing Process 2 Methods of preparation of thiamine: 1. 3-Ethoxypropionitrile reacted with diethoxymethoxy-ethane and 3-ethoxy- 2-methoxymethylenpropionitrile was obtained. Then to the 3-ethoxy-2-methoxymethylenpropionitrile acetamidine was added and reaction mixture was stirred to give 4-amino-5-ethoxy-methyl-2- methylpyrimidine. The 4-amino-5-ethoxy-methyl-2-methylpyrimidine was treated by hydrobromic acid to afford 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide. The 4-amino-5-bromomethyl-2-methylpyrimidine hydrobromide reacted with 5-(2-hydroxyethyl)-4-methylthiazole in the presence of hydrobromic acid and as the result thiaminbromide was produced. For changing of the thiaminbromide to the thiamincloride the thiaminbromide was treated by AgCl. 2. To diethoxymethoxy-ethane malononitrile was added and ethoxymethylenmalononitrile was obtained. The ethoxymethylen-malononitrile reacted with acetamidine as a result 4-amino-5-cyano-2-methylpyrimidine was produced, which was reduced by H2/Raney-Ni to 4-amino-5-aminomethyl-2- methylpyrimidine. To the 4-amino-5-aminomethyl-2-methylpyrimidine 1-acetoxy-3-chloropentan- 4-one was added in the presence CS2 and NH3, and reaction mixture was stirred, then to this mixture hydrochloric acid was added and thiamin (base) was obtained. To thiamin (base) H2O2 and hydrocloricum acid are added, in the result reaction the thiamine chloride was obtained. Therapeutic Function Enzyme cofactor vitamin, Antineuritic General Description Thiamine, the preferred name for vitamin B1, holds a prominent place in the history of vitamin discovery because beriberi, the disease resulting from insufficient thiamine intake, was one of the earliest recognized deficiency diseases. Biological Activity Some earlier designations for this substance included aneurin, antineuritic factor, antiberiberi factor, and oryzamin. Thiamine is metabolically active as thiamine pyrophosphate (TPP). TPP functions as a coenzyme which participates in decarboxylation of α-keto acids. Dehydrogenation and decarboxylation must precede the formation of “active acetate” in the initial reaction of the TCA cycle (citric acid cycle):    This reaction is a good example of the interrelationship of vitamin B coenzymes. Four vitamin coenzymes are necessary for this one reaction: (1) thiamine (in TPP) for decarboxylation; (2) nicotinic acid in nicotinamide adenine dinucleotide (NAD); (3) riboflavin in flavin adenine dinucleotide (FAD); and (4) pantothenic acid in coenzyme A (CoA) for activation of the acetate fragment. Clinical Use Thiamine chloride, as the base or as the hydrochloride salt, is indicatedin the treatment or prophylaxis of known or suspected thiaminedeficiencies. Severe thiamine deficiency is calledberiberi, which is very rare in developed countries. The mostlikely cause of thiamine deficiency in the United States is theresult of chronic alcoholism, which leads to multiple vitamindeficiencies as a result of poor dietary intake. The major organsaffected are the nervous system (dry beriberi), whichmanifests as neurological damage, the cardiovascular system(wet beriberi), which manifests as heart failure and edema, andthe gastrointestinal tract. Thiamine administration reverses thegastrointestinal, cardiovascular, and neurological symptoms;however, if the deficiency has been severe or of prolonged duration, the neurological damage may be permanent. Safety Profile Poison by subcutaneous and intravenous routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Cl-.   Thiamine chloride Preparation Products And Raw materials Raw materials Ethanol-->Hydrogen peroxide-->Dimethyl sulfate-->Chlorosulfonic acid-->Acrylonitrile-->Ethyl formate-->2-Acetylbutyrolactone Preparation Products Sulfadiazine-->5-Pyrimidinecarboxaldehyde, 4-amino-2-methyl- (6CI,7CI,8CI,9CI)-->2-Methyltetrahydrofuran-3-one-->Furfural-->5-(2-Hydroxyethyl)-4-methylthiazole

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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