China Largest Manufacturer factory sales Meglumine CAS 6284-40-8

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Meglumine Basic information Product Name: Meglumine Synonyms: 1-deoxy-1-(methylamino)-d-glucito;1-Deoxy-1-(methylamino)hexitol;Glucitol, 1-deoxy-1-(methylamino)-, D-;Meglumin;Methylglucamin;Methylglucamine;D-GLUCITOL, 1-DEOXY-1-(METHYLAMINO)-;D(-)-N-METHYLGLUCAMINE CAS: 6284-40-8 MF: C7H17NO5 MW: 195.21 EINECS: 228-506-9 Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aminosugars;Biochemistry;Sugars;PREDEF;Diagnostic agents;API Mol File: 6284-40-8.mol   Meglumine Chemical Properties Melting point  129-131.5 °C (lit.) alpha  -16.5 º (c=10, H2O, on dry sub) Boiling point  331.88°C (rough estimate) density  1.2669 (rough estimate) RTECS  LZ4295770 refractive index  -16.5 ° (C=2, H2O) storage temp.  2-8°C solubility  H2O: 0.1 g/mL, clear, colorless form  Crystalline Powder pka pKa 9.39(H2O,t =30.0,I=0.05N2)(Approximate) color  White to almost white PH 11 (10g/l, H2O, 20℃) optical activity [α]20/D 16.5±0.5°, c = 2% in H2O Water Solubility  100 g/100 mL (25 ºC) Sensitive  Air Sensitive & Hygroscopic Merck  14,6078 BRN  385906 InChIKey MBBZMMPHUWSWHV-VZFHVOOUSA-N NIST Chemistry Reference N-methylglucamine(6284-40-8) EPA Substance Registry System Meglumine (6284-40-8)   Safety Information Risk Statements  36/37/38 Safety Statements  24/25 WGK Germany  3 F  3-10-23 Autoignition Temperature ~662 °F TSCA  Yes HS Code  29221980 Toxicity LD50 orally in Rabbit: > 5000 mg/kg MSDS Information Provider Language Meglumine English SigmaAldrich English ACROS English ALFA English   Meglumine Usage And Synthesis Chemical Properties white to almost white crystalline powder Chemical Properties Meglumine occurs as a white to slightly yellow-colored crystalline powder; it is odorless or with a slight odor. Uses antiinflammatory Uses excipient in cosmetics and X-ray contrast media Uses N-Methyl-D-glucamine is used in conjunction with iodinated organic compounds in contrast media viz. diatrizoate meglumine and iodipamide meglumine. It is useful in ion-exchange resins to chelate boron ions selectively. It is also used as an excipient in pharmaceuticals, in cosmetics and X-ray contrast media. It is also employed in the synthesis of surface active agents, pharmaceuticals and dyes. Production Methods Meglumine is prepared by the imination of glucose and monomethylamine, in an alcoholic solution, followed by catalytic hydrogenation. Definition ChEBI: A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, whi e its antimonate is used as an antiprotozoal in the treatment of leishmaniasis. Brand name Renovue (Bracco). General Description Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Meglumine is a glucose-derived secondary amine which is widely used as an excipient in pharmaceutical formulations. Pharmaceutical Applications Meglumine is an organic base used as a pH-adjusting agent and solubilizing agent, primarily in the preparation of soluble salts of iodinated organic acids used as X-ray contrast media. Safety Meglumine is widely used in parenteral pharmaceutical formulations and is generally regarded as a nontoxic material at the levels usually employed as an excipient. LD50 (mouse, IP): 1.68 g/kg storage Meglumine does not polymerize or dehydrate unless heated above 150°C for prolonged periods. The bulk material should be stored in a well-closed container in a cool, dry place. Meglumine should not be stored in aluminum containers since it reacts to evolve hydrogen gas; it discolors if stored in containers made from copper or copper alloys. Stainless steel containers are recommended. Purification Methods Crystallise N-methyl-D(-)-glucamine from MeOH. Its solubility in H2O is 10%. [Karrer & Herkenrath Helv Chim Acta 20 83 1957 also for other N-alkyl derivatives, Beilstein 4 IV 1914.] Incompatibilities Incompatible with aluminum, copper, mineral acids, and oxidizing materials. Differential scanning calorimetry studies suggest meglumine is incompatible with glipizide. Regulatory Status Included in the FDA Inactive Ingredients Database (injections; oral tablets). Included in parenteral medicines licensed in the UK.   Meglumine Preparation Products And Raw materials Raw materials ACETALDEHYDE AMMONIA-->1-Glucose-methylamine schiffbase Preparation Products MGD SODIUM SALT MONOHYDRATE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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