China Original Largest Manufacturer sales 2-Thiouracil CAS 141-90-2

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2-Thiouracil Basic information Product Name: 2-Thiouracil Synonyms: 2-Thiouracil Vetec(TM) reagent grade, 99%;2-ThiouraCll;4-HYDROXY-2-MERCAPTOPYRIMIDINE;4-HYDROXY-2-THIOPYRIMIDINE;2-MERCAPTO-4-PYRIMIDONE;2-MERCAPTO-4-HYDROXYPYRIMIDINE;2-thio-uraci;2-TU CAS: 141-90-2 MF: C4H4N2OS MW: 128.15 EINECS: 205-508-8 Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;Heterocyclic Compounds;PYRIMIDINE;FINE Chemical & INTERMEDIATES;Bases & Related Reagents;Nucleotides;Nucleic acids;Sulfur & Selenium Compounds;Building Blocks;C4 to C5;Chemical Synthesis;Heterocyclic Building Blocks;Pyrimidines Mol File: 141-90-2.mol   2-Thiouracil Chemical Properties Melting point  >300 °C (lit.) density  1.368 (estimate) refractive index  1.7000 (estimate) storage temp.  Store below +30°C. solubility  7.9g/l pka pKa 7.46 (Uncertain) form  Fine Crystalline Powder color  White to cream Water Solubility  0.5 g/L λmax 271nm(H2O)(lit.) Merck  14,9366 BRN  112227 InChIKey ZEMGGZBWXRYJHK-UHFFFAOYSA-N CAS DataBase Reference 141-90-2(CAS DataBase Reference) IARC 2B (Vol. Sup 7, 79) 2001 NIST Chemistry Reference 2-Thiouracil(141-90-2) EPA Substance Registry System Thiouracil (141-90-2)   Safety Information Hazard Codes  Xn,T Risk Statements  40-45-20/21/22 Safety Statements  36/37-53-45 WGK Germany  3 RTECS  YR1575000 TSCA  Yes HS Code  29335995 Hazardous Substances Data 141-90-2(Hazardous Substances Data) MSDS Information Provider Language 4-Hydroxy-2-mercaptopyrimidine English ACROS English SigmaAldrich English ALFA English   2-Thiouracil Usage And Synthesis Chemical Properties white to cream fine crystalline powder Uses Reagent used in the preparation of Antithyroid agents. Uses antiviral, thyroid depressant Uses 2-Thiouracil has been used in the synthesis and characterization of silver colloid and film substrates and their applications in surface-enhanced Raman scattering (SERS) Definition ChEBI: A nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group. Biochem/physiol Actions 2-Thiouracil is a thio-derivative of uracil, a pyrimidine nucleobase. It acts as an anticancer, antithyroid, and antiviral agent. 2-Thiouracil is a selective melanoma-seeker and competitive inhibitor of neuronal nitric oxide synthase. It also forms complexes with transition metals such as gold (Au), Chromium (Cr), Zinc (Zn), and Silver (Ag). Safety Profile Moderately toxic by ingestion. Human teratogenic effects by unspecified routes: developmental abnormalities of the central nervous system, craniofacial area, and endocrine system. Human reproductive effects by unspecified route: effects on newborn, including viabllity index changes. Experimental teratogenic effects. Other experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic and tumorigenic data. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used in the treatment of hyperthyroidism, angina pectoris, and congestive heart failure. See also MERCAPTANS and KETONES. Purification Methods Crystallise 2-thiouracil from water or EtOH. [Beilstein 24 H 323, 24 I 315, 24 II 171, 24 III/IV 1237.]   2-Thiouracil Preparation Products And Raw materials Raw materials Sodium methoxide-->Thiourea-->4-AMINO-2-MERCAPTOPYRIMIDINE-->2-THIOURIDINE Preparation Products 4-Hydroxypyrimidine-->4-THIOURACIL-->4-Chloro-2-(methylsulfonyl)pyrimidine-->N-(4-AMINOPYRIMIDIN-2-YL)-N-METHYLAMINE-->2-Methylthio-4-pyrimidinol-->5-BROMO-4-CHLORO-2-METHANESULFONYL-PYRIMIDINE-->5-BROMO-4-CHLORO-2-METHYLSULFANYL-PYRIMIDINE-->PYRIMIDIN-4-OL-->4-Pyrimidinol-->Pyrimidine, 4-bromo- (8CI,9CI)-->4-CHLORO-N-METHYLPYRIMIDIN-2-AMINE-->BENZYL-(2-METHYLSULFANYL-PYRIMIDIN-4-YL)-AMINE-->4-Chloro-2-methylthiopyrimidine-->DITHIOURACIL

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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