China Largest Manufacturer factory sales Bucladesine/Bucladesine Sodium/Sodium Dibutyryladenosine Cyclophosphate CAS 16980-89-5

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ucladesine Basic information Product Name: Bucladesine Synonyms: dibutylcyclicampsodium;dibutylcyclicampsodiumsalt;dt5621sodiumsalt;e,butyrate(ester),monosodiumsalt;monosodiumdibutyrylcyclicamp;n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-butyramidcyclichydrogenphosphat;n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt;n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt CAS: 16980-89-5 MF: C18H23N5NaO8P MW: 491.37 EINECS: 241-059-4 Product Categories: Cyclic Nucleotide related;API Mol File: 16980-89-5.mol   Bucladesine Chemical Properties Melting point  >173°C (dec.) storage temp.  -20°C solubility  H2O: 50 mg/mL form  powder color  white Merck  14,1463 Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.   Safety Information Safety Statements  24/25 WGK Germany  2 RTECS  ES5055500 F  10-21 HS Code  29349990 MSDS Information Provider Language SigmaAldrich English   Bucladesine Usage And Synthesis Description Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery. Originator Daiichi Seiyaku; Seishin Seiyaku (Japan) Uses N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used: as a medium supplement for neural crest stem cells (NCSCs) differentiation as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation Uses Cardiotonic;Adenylate cyclase modulator Uses An analog of cyclic AMP that stimulates cAMP-dependent protein kinase Brand name ACTOCIN General Description A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells. Biological Activity Cell-permeable analog of cAMP; activates cAMP-dependent protein kinases. Biochem/physiol Actions Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA). References 1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321 2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511 3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233 4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139 5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270   Bucladesine Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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