China Largest Manufacturer factory sales Dextran Sulfate Sodium CAS 9011-18-1

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Dextran Sulfate Sodium Salt Basic information Description Uses Toxicity Product Name: Dextran Sulfate Sodium Salt Synonyms: asuro;dexnon;Dextran sulfate sodium salt, M.W 5,000;Dextran sulfate sodium salt, M.W 6,500-10,000;OmniPur Dextran Sulfate Sodium - CAS 9011-18-1 - Calbiochem;Dextran sulfate sodium salt,Mw 40,000;Dextran sulfate sodium salt,Mw 20,000;Dextran Sulfate, Sodium Salt, Molecular Biology Grade - CAS 9011-18-1 - Calbiochem CAS: 9011-18-1 MF: (C6H7Na3O14S3)n MW: 0 EINECS: 618-471-1 Product Categories: Dextrins、Sugar & Carbohydrates;Carbohydrates;Carbohydrates A to;Carbohydrates D-FBiochemicals and Reagents;CarbohydratesCarbohydrates;Core Bioreagents;Polysaccharide;Research Essentials;gel;Material Mol File: Mol File   Dextran Sulfate Sodium Salt Chemical Properties storage temp.  room temp solubility  H2O: 100 mg/mL form  powder color  White to off-white PH pH(50g/l, 25℃）4.5～8.0 Water Solubility  Soluble in water. Merck  2951 EPA Substance Registry System Dextran, hydrogen sulfate, sodium salt (9011-18-1)   Safety Information Hazard Codes  Xi,Xn Risk Statements  20/21/22-36/37/38 Safety Statements  26-36-37/39-24/25 WGK Germany  2 RTECS  HH9290000 F  3-10 TSCA  Yes HS Code  39139000 MSDS Information Provider Language Dextran sulfate sodium English SigmaAldrich English   Dextran Sulfate Sodium Salt Usage And Synthesis Description Dextran sulfate (dextran hydrogen sulfate, sodium salt) has been tested as a potential substitute for heparin in anticoagulant therapy. Following studies by Ingelman, Walton and Ricketts explored the anticoagulant properties of a wide range of dextran sulfates (Mw 7000 to 458000) and established that the lowest molecular weight products displayed the highest anticoagulant properties. However, at best this only represented 15% of heparin's activity. With the introduction of low-dose heparin therapy for thrombosis prophylaxis in the 70's, interest in low molecular weight polyanions has been rekindled and reports on interactions with individual enzyme/inhibitor systems in the coagulation cascade have appeared. Dextran sulfate immobilized on cellulose has been found to remove LDL cholesterol preferentially during plasmaphoresis. Its wide spectrum of biological properties has attracted the attention of many scientists. The reports may be grouped according to the following biological effects. Enzyme inhibition, activation and release Adjuvant effect on immune response Cellular interactions and response Effect on virus infectivity Uses Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The high purity and reproducible quality enables its application in pharmaceuticals and biotechnology industry. Dextran sulfate is used asa nucleic acid hybridization accelerant. The polyanionic character of Dextran sulfate helps to approximate nucleic acid strands, increasing their effective concentration to each other and promoting hybridization. Dextran sulfate also demonstrates a sequestering interaction with proteins, presumably through hydrogen-bonding between the sulfate groups and amine groups of the protein that generates an insoluble complex. The ability of the polymer to precipitate fibrinogen and low-density lipoproteins from plasma solutions has been used for analysis and for anticoagulant applications. Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.Oral administration of dextran sulfate induces colonic inflammation in a mouse model of inflammatory bowel disease (IBD). Acute, chronic, and relapsing models of IBD can be induced by varying the concentration and administration frequency of dextran sulfate. Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein. Toxicity The toxicity of these products had been recognized at an early stage. Nevertheless, a low molecule weight fraction with Mw 7000 and S, 16% was considered to be qualitatively similar to heparin. Preliminary clinical trials were unfortunately discouraging and revealed severe adverse reactions, notably, stiff and painful joints, skin eruption, loss of hair and gastro-intestinal symptoms. In chronic toxicity studies in animals, retardation in weight gain and osteoporosis with spontaneous fractures were observed. It should be noted that the doses in the clinical trials corresponded to 1.3 g/day, which is approximately tenfold that used in current heparin therapy. More recently attention has been focussed on the toxicity of orally administered substance. Supplements of 0.25% and 0.5% for 82 weeks in rats did not increase the incidence of infection or tumours. Higher doses (1–10%) resulted in mortality and tumours. Apart from dosage, the toxicity is also dependent on Mw. Adsorption studies in the gut using a wide range of dextran sulfates (3000–200000) suggest only a small proportion of the dose is absorbed. Intravenous administration has also been investigated. The inhibition of metastasis by dextran sulfate (Mw 6–7 x 10 3 , DS approx. 2) has been tested clinically but the 5 year survival rate in lung cancer was not improved. Tests for mutagenicity and cytogenicity of low MW dextran sulfate proved negative. Chemical Properties White to off-white powder Uses Clinical reagent (HDL cholesterol determination). Uses Clinical studies indicate a possible capacity of dextran sulfate to reduce edema. It is cited as a binder and skin conditioner. Uses Dextran sulfate sodium salt Leuconostoc spp has been used: as a standard to perform polyacrylamide-gel electrophoresis for carbohydrates (C-PAGE)(59) and agarose gel electrophoresis(60) for RNA sequential probing of targets (SPOTs) imaging(61) as a component of 1% injection buffer(62) General Description Dextran sulfate is a sulfated polysaccharide, which is negatively charged. It is produced by the esterification of dextran with chlorosulphonic acid. Dextran is used to treat hemorrhage, burns, surgery and trauma. It improves blood flow and prevents erythrocyte aggregation. Dextran lowers the risk of thrombosis and postoperative pulmonary emboli. It is a ribonuclease inhibitor. Dextran sulfate exhibits antiviral, anticoagulant and adjuvant properties. Biochem/physiol Actions Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.   Dextran Sulfate Sodium Salt Preparation Products And Raw materials Raw materials Dextran-->Pyridine sulfur trioxide

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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