China Largest Manufacturer factory sales D(+)-Tryptophan CAS 153-94-6

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D(+)-Tryptophan Basic information Description Description Characteristics and Functions Project Standards Application References References Product Name: D(+)-Tryptophan Synonyms: D-TRP;D(+)-TRYPTOPHAN;D-TRYPTOPHAN;D-TRYPTOPHANE;D-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID;D-2-AMINO-3-INDOLEPROPIONIC ACID;D-2-AMINO-3-INDOLYLPROPANOIC ACID;D-ALPHA-AMINO-3-INDOLEPROPIONIC ACID CAS: 153-94-6 MF: C11H12N2O2 MW: 204.23 EINECS: 205-819-9 Product Categories: tadalafil intermediate;Intermediate of Tadalafil;Amino Acids & Derivatives;Aromatics;Heterocycles;Isotope Labelled Compounds;Amino Acid Derivatives;Tryptophan [Trp, W];Amino Acids and Derivatives;alpha-Amino Acids;Amino Acids;Biochemistry;Indoles;Indole Derivatives;Amino Acids Derivatives;Tryptophans;Chiral Compound;Amino Acids;Thiophenes;1 Mol File: 153-94-6.mol   D(+)-Tryptophan Chemical Properties Melting point  282-285 °C (dec.)(lit.) alpha  31.5 º (c=1, H2O 24 ºC) Boiling point  342.72°C (rough estimate) density  1.1754 (rough estimate) refractive index  31 ° (C=1, H2O) storage temp.  Keep in dark place,Inert atmosphere,Room temperature solubility  Aqueous Base (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly) pka 2.30±0.10(Predicted) form  Powder color  White to slightly yellow Water Solubility  11 g/L (20 ºC) BRN  86198 Stability: Stable. Incompatible with oxidizing agents. InChIKey QIVBCDIJIAJPQS-SECBINFHSA-N CAS DataBase Reference 153-94-6(CAS DataBase Reference) EPA Substance Registry System D-Tryptophan (153-94-6)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38-41-37/38-22 Safety Statements  24/25-36/37/39-36-26 WGK Germany  3 RTECS  YN6129000 F  8 TSCA  Yes HazardClass  IRRITANT HS Code  29339990 MSDS Information Provider Language (R)-2-Amino-3-(3-indolyl)propionic acid English ACROS English SigmaAldrich English ALFA English   D(+)-Tryptophan Usage And Synthesis Description D(+)-tryptophan is the D-form (non-proteinogenic form) of the amino acid tryptophan. It can be used for Human embryonic kidney cell (HEK-293, ATCC: CRL-1573) culture. It is also a sweetener used to study the release of incretins from enteroendocrine cells triggered by sugar but not by sweeteners. Description D-tryptophan (Full name D (+)-Tryptophan) is a white to pale yellow or white crystalline powder at room temperature, odorless or slight odor, slightly sweet taste. Solubility in water is 1.14 g (25 ℃), soluble in dilute acid and alkali, stable in alkali, decomposed in strong acid, slightly soluble in ethanol, not soluble in chloroform, ethyl ether. It plays an important role for human and animal growth and development, metabolism, known as the second essential amino acids. They are almost identical with L-type and physical and chemical properties, and only the optical activity is opposite. But their distribution, function and coenzyme have diversity. Its melting point is very high, generally above 200 degrees. It can dissolve in water, and in the near UV region it has the ability to absorb light. Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet. It is encoded in the standard genetic code as the codon UGG. the D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). The distinguishing structural characteristic of tryptophan is that it contains an indole functional group. It is an essential amino acid as defined by its growth effects on rats. Characteristics and Functions D-tryptophan amino acid, as a non-reactive protein, has special physiological properties. It can be used as a non-nutritive sweeteners, feed additive, plant growth agents in food feed industry and agriculture. In the pharmaceutical industry, it mainly used for the synthesis of various polypeptides, instead of L-tryptophan peptide drug for half-life extending and reduce the side effects, but it will not resistant to the front body, and it will become important enzyme inhibitor. It can also improve the body's immunity, delayed allergic reactions. Most peptide antibiotic can resistant gram-positive bacteria, Gram-negative bacteria and some, such as Pseudomonas aeruginosa, mycobacteria, fungi, bacteria, pathogens and tumor cells, which have better inhibit and kill ability. D-tryptophan can be used for the synthetic of semi-synthetic antibiotics, for which pharmacological plays an important role for the side chain. The peptide bond is difficult to be β-lactam enzyme action, thus high stability, and has broad antibacterial spectrum, toxicity, hypoallergenic, rapid absorption, high blood concentrations of the drug long duration. Project Standards Appearance  white or slightly yellow crystalline powder Content 99.0%~101.0% Specific rotation [α] D20 + 30.5 °~+ 32.5 ° Transmittance ≥95.0% Acidity PH 5.5~6.4 Loss on drying ≤0.2% Residue on ignition ≤0.1% Chloride [Cl-] ≤0.02% Sulphate [SO42-] ≤0.02% Ammonium [NH4 +] ≤0.02% Heavy metals [Pb] ≤10ppm Ferric [Fe] ≤10ppm Arsenic salt [As2O3] ≤1ppm Other amino acids compliance Application An important nutrient, niacin is used as the control agent Medicine Production method: D-tryptophan as raw material, chloroacetic anhydride was added under cooling state after polishing sulfuric acid in ice water, filtered and recrystallized from water, and finally treatment with carboxypeptidase trypsin to remove L-type, acidified with acetic acid, ethanol recrystallization refining. References # References Fujita, Yukihiro, et al. "Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo." American Journal of Physiology Endocrinology & Metabolism 296.3(2009):E473. Bacchus, W, W. Weber, and M. Fussenegger. "Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species." Metabolic Engineering 15.1(2013):144. Chemical Properties white powder Uses An essential amino acid found in naturally produced pedtides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins. Uses An essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins. Uses D-Tryptophan is used for human embryonic kidney cell (HEK-293, ATCC: CRL-1573) culture. The product is a sweetener used to study the release of incretins from enteroendocrine cells triggered by sugar but not by sweeteners. Definition ChEBI: The D-enantiomer of tryptophan. General Description White solid. Air & Water Reactions Slightly soluble in water. Reactivity Profile Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Fire Hazard Flash point data are not available for D(+)-Tryptophan, but D(+)-Tryptophan is probably combustible. Biochem/physiol Actions Low level of D-tryptophan is capable of preventing the growth of an L-tryptophan-requiring mutant of the E. coli.   D(+)-Tryptophan Preparation Products And Raw materials Raw materials DL-Tryptophan-->Chloroacetic anhydride-->N-ACETYL-D-TRYPTOPHAN-->L-Tryptophan Preparation Products 13(S)-HYDROXYOCTADECA-9Z,11E-DIENOIC ACID-->N-Cbz-D-Tryptophan

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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