China Largest Factory Manufacturer sales Kanamycin Sulfate CAS 25389-94-0

Superiority:

                                PRODUCT DETAILS       

Kanamycin sulfate Basic information Description Reference Product Name: Kanamycin sulfate Synonyms: KANAMYCIN MONOSULFATE GAMMA-IRRADIATED*M OLECULAR BI;KANAMYCIN MONOSULFATE FROM STREPTOMYCES KANAMYCETIC;KANAMYCIN MONOSULFATE, BPC GRADE;KANAMYCIN SOLUTION 50MG/ML (STERILE*FILT ERED) CELL;KANAMYCIN SULFATE USP(CRM STANDARD);KANAMYCIN SULFATE USP 99%;KANAMYCIN SULFATE, MOLECULAR BIOLOGY GRADE;KANAMYCIN SULFATE CELL CULTURE GRADE 99% CAS: 25389-94-0 MF: C18H38N4O15S MW: 582.58 EINECS: 246-933-9 Product Categories: Inhibitors;Amines;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;API;Aminoglycosides (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Antibiotic Explorer;Peptide Synthesis/Antibiotics;KANTREX;antibiotic Mol File: 25389-94-0.mol   Kanamycin sulfate Chemical Properties Melting point  250°C alpha  +112～+123°(D/20℃)(c=1,H2O)(calculated on the dried basis) density  1.3619 (rough estimate) refractive index  117.5 ° (C=1, H2O) storage temp.  2-8°C solubility  H2O: 10-50 mg/mL As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days. form  powder color  white to off-white PH Range 6.5 - 8.5 (1% solution) Water Solubility  Soluble in water at 10mg/ml Merck  14,5281 InChIKey OOYGSFOGFJDDHP-KMCOLRRFSA-N   Safety Information Hazard Codes  T Risk Statements  61 Safety Statements  22-24/25-45-53 WGK Germany  3 RTECS  NZ3225030 HS Code  29419020 Toxicity LD50 in mice: 20.7 g/kg orally; 1450 mg/kg i.p. (Zel'tser) MSDS Information Provider Language Kanamycin A monosulfate English SigmaAldrich English   Kanamycin sulfate Usage And Synthesis Description It has been well known as desirable antibiotics, which shows an obvious curative effect on serious infections caused by gram-negative bacteria such as Escherichia coil, Klebsiella, Proteus, Pneumonia, Enterobacter aerogenes and Shigella. Clinically, this substance is mainly used for infections caused by sensitive bacteria including pulmonary infection, urinary tract infection, biliary tract infection, sepsis, and abdominal cavity infection. For example, the effective antibacterial activity of kanamycin sulfate has been demonstrated by the treatment of acute gonorrheal urethritis in men, showing that a single parenterally administered dose of 2 mg of kanamycin sulfate cured 144 (93%) of 155 men with acute gonorrheal urethritis.1 Moreover, kanamycin sulfate was found to be a valuable drug in the treatment of serious infections in infants and children through an analysis of 140 cases treated during a two-year period.2 Reference JE Fischnaller; AH Pedersen; AR Ronald; P Bonin; Tronca, E., Kanamycin sulfate in the treatment of acute gonorrheal urethritis in men. The Journal of the American Medical Association 1968, 203, 909-912. MD Yow; Tengg, N., The use of kanamycin sulfate as a therapeutic agent for infants and children. An analysis of 140 cases treated during a two-year period. Journal of Pediatrics 1961, 58, 538-547. Chemical Properties Off-white powder Originator Kantrex,Bristol,US,1958 Uses Kanamycin monosulfate, is used as an aminoglycoside antibiotic. Kanamycin can be used as a selection agent in several types of isolation media.Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100mg/mL. Uses Antibiotic complex produced by Streptomyces kanamyceticus Okami & Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial. Uses Kanamycin sulfate is an antibacterial agent similar to neomycin. Definition A broadspectrum antibiotic. Manufacturing Process As described in US Patent 2,931,798, Streptomyces kanamyceticus (K2-J) was first cultured in shake flasks in the following media: (a) 0.75% meat extract, 0.75% peptone, 0.3% NaCl, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol; or (b) 2.0% soybean meal, 0.05% KCl, 0.05% MgSO4 · 7H2O, 0.5% NaCl, 0.2% NaNO3, with 1.0% of starch, dextrin, maltose, glucose, lactose, sucrose or glycerol. The initial pH of all media was adjusted to 7.0. After 24 to 48 hours shaking in some cases the pH decreased to about 6.0 to 6.8, but from 72 to 120 hours the pH rose and became 7.5 to 8.6. The production of kanamycin was apparent after 48 hours and, depending on the media; the maximum production was found after 72 to 120 hours. The yield was highest with starch or dextrin, intermediate and about the same with sucrose, glucose, maltose and lactose and poorest with glycerol. Kanamycin was produced by media containing soybean meal, peanut meal, cottonseed meal, corn steep liquor, peptone, yeast extract or meat extract, with or without sodium nitrate. Commercially available soybean meal was recognized to be one of the best nitrogen sources. The addition of corn steep liquor, peptone, yeast extract or nitrate to the soybean meal promoted the production of kanamycin. The brownish white kanamycin (5 g) was dissolved in 50 ml of 60% aqueous methanol, insoluble material was removed and to the filtrate 40 ml of 60% aqueous methanol containing 2,000 mg of ammonium sulfate was added, and the precipitated kanamycin sulfate was collected, washed with 50 ml of 80% aqueous methanol, and dried. Thus, 4.5 g of kanamycin sulfate was obtained as a light brownish powder. Brand name Klebcil (King). Therapeutic Function Antibacterial General Description Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 2 mL/L. Biochem/physiol Actions Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes.Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.   Kanamycin sulfate Preparation Products And Raw materials Raw materials Ethanol-->Ammonium chloride-->Sodium bisulfite-->Sodium nitrate-->Zinc sulphate-->FERROUS SULFATE-->SOYBEAN MEAL-->Dextrin

                                                                About Our Group

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

                                                                      Our Group profiles

Our Factories production lines

                                                   Our Factories R&D ability

                        Our Factories warehouse