China Largest Factory Manufacturer sales Methyl gallate CAS 99-24-1

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Methyl gallate

Alias: Methyl 3,4,5-trihydroxybenzoate

Product name: Methyl gallate

CAS number: 99-24-1 ^[1]

Molecular formula: C₈H₈O₅

Molecular weight: 184.1461

Density: 1.501g/cm³

Melting point: 201-203°C (157°C, hydrate or solvated crystal).

Boiling point: 450.1°C at 760 mmHg

Flash point: 190.8°C

Vapor pressure: 1.02E-08mmHg at 25°C

Property description: Monoclinic prismatic crystal (methanol). Soluble in hot water, ethanol, ether

Used as an intermediate for biphenyl bisphenol and other drugs. Also as rubber antioxidant

Methyl gallate Basic information Product Name: Methyl gallate Synonyms: 3,4,5-trihydroxybenzoic acid methyl ester (intermediate of bifendate);METHYL GALLATE(METHYL 3,4,5-TRIHYDROXYBENZOATE );METHYLGALLATE(RG);2-diazo-1-naphthol-5-sulfonic acid, ester with novolac;METHYGALLATE;3,4,5-trihydroxy-benzoic acidd methyl ester;METHYL 3,4,5-TRIHYDROXYBENZOATE / METHYL GALLATE;Gallic acid methyl ester, Methyl 3,4,5-trihydroxybenzoate CAS: 99-24-1 MF: C8H8O5 MW: 184.15 EINECS: 202-741-7 Product Categories: Food additive ,Antioxidant anticorrosive;(intermediate of bifendate);Photo Active Compounds;Aromatic Esters;Organic acids Mol File: 99-24-1.mol   Methyl gallate Chemical Properties Melting point  201-204 °C Boiling point  278.08°C (rough estimate) density  1.3840 (rough estimate) refractive index  1.5690 (estimate) storage temp.  Inert atmosphere,Room Temperature solubility  ethanol: 50 mg/mL, clear form  Crystalline Powder pka 8.04±0.23(Predicted) color  White to slightly beige Water Solubility  SOLUBLE IN HOT WATER Merck  14,4345 BRN  2113180 InChIKey FBSFWRHWHYMIOG-UHFFFAOYSA-N CAS DataBase Reference 99-24-1(CAS DataBase Reference) EPA Substance Registry System Benzoic acid, 3,4,5-trihydroxy-, methyl ester (99-24-1)   Safety Information Hazard Codes  Xn,Xi Risk Statements  22-36/37/38-43 Safety Statements  26-36/37-24/25 WGK Germany  3 RTECS  LW8000000 TSCA  Yes HS Code  29182900 MSDS Information Provider Language Methyl gallate English ACROS English SigmaAldrich English ALFA English   Methyl gallate Usage And Synthesis Description Methyl gallate is a phenolic compound found in Terminalia myriocarpa and Geranium niveum. It is also found in wine. It is the methyl ester of gallic acid. Description Methyl gallate is a phenol that has been found in Meliaceae and has diverse biological activities. It reduces adipogenic hormonal stimulation-induced lipid accumulation in 3T3-L1 cells when used at a concentration of 50 μM. Methyl gallate is active against V. cholerae in vitro (MIC = 32 μg/ml) and reduces V. cholerae-induced intestinal fluid accumulation in suckling mice when administered at doses of 50, 100, and 200 mg/kg. It reduces tumor growth and decreases the number of intratumor CD25+Foxp3high regulatory T cells (Tregs) in an EL-4 model of murine lymphoma. Methyl gallate (0.7, 7, and 70 mg/kg) reduces knee joint edema and leukocyte, neutrophil, and mononuclear cell infiltration in a mouse model of zymosan-induced arthritis. Chemical Properties white to slightly beige crystalline powder Uses Methyl gallate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. Uses The gallate ester methyl gallate is used as an antioxidant. A ease was reported using a reprography paper. Uses Methyl 3,4,5-trihydroxybenzoate exhibits potent antitumor activities by inhibiting tumor infiltration of CD4+CD25+ regulatory T cells. Contact allergens This ester of gallic acid is used as an antioxidant agent. A case was reported by using a reprography paper. Purification Methods Methyl gallate [99-24-1] M 184.2, m 202o. Crystallise the gallate ester from MeOH. [Beilstein 10 IV 1998.]   Methyl gallate Preparation Products And Raw materials Raw materials Gallic acid Preparation Products 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER-->3,4-DIHYDROXY-5-METHOXYBENZOIC ACID METHYL ESTER-->1,3-Benzenediol, 2,5-dimethoxy--->(4'-O-methyl)methyl gallate-->Octyl gallate-->5-METHYLPYROGALLOL-->Methyl 4,5-dimethoxy-3-hydroxybenzoate-->Methyl 3,4,5-trimethoxybenzoate-->7-(dimethylamino)-3,4-dihydroxy-1-(methoxycarbonyl)phenoxazin-5-ium chloride

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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