China Largest Factory Manufacturer sales 5-Bromonicotinic Acid CAS 20826-04-4

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5-Bromonicotinic acid Basic information Product Name: 5-Bromonicotinic acid Synonyms: RARECHEM AL BO 0841;TIMTEC-BB SBB003524;AKOS BBS-00007710;3-PYRIDINECARBOXYLIC ACID, 5-BROMO-;3-BROMO-5-PYRIDINE CARBOXYLIC ACID;3-BROMO PYRIDINE-5-CARBOXYLIC ACID;5-BROMO-3-PYRIDINECARBOXYLIC ACID;5-BROMONICOTINC ACID CAS: 20826-04-4 MF: C6H4BrNO2 MW: 202.01 EINECS: 244-065-5 Product Categories: Pyridines, Pyrimidines, Purines and Pteredines;pharmacetical;Heterocycles;Bromopyridines;Halopyridines;alkyl bromide|carboxylic acid;blocks;Bromides;Pyridine series;Carboxylic Acids;Organic acids;Pyridines derivates;PROTECTED AMINO ACID & PEPTIDES;Carboxylic Acids;Carboxes;Pyridines;Pyridine;pyridine derivative;Acids and Derivatives Mol File: 20826-04-4.mol   5-Bromonicotinic acid Chemical Properties Melting point  178-180 °C(lit.) Boiling point  259.67°C (rough estimate) density  1.7477 (rough estimate) refractive index  1.6120 (estimate) storage temp.  2-8°C solubility  DMSO (Slightly), Methanol (Slightly) form  Powder pka 3.08±0.10(Predicted) color  White to yellow-gray or light brown BRN  115854 InChIKey FQIUCPGDKPXSLL-UHFFFAOYSA-N CAS DataBase Reference 20826-04-4(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36-24/25 WGK Germany  3 RTECS  QT0868000 Hazard Note  Irritant HazardClass  IRRITANT HS Code  29333999 MSDS Information Provider Language 5-Bromonicotinic acid English SigmaAldrich English ACROS English ALFA English   5-Bromonicotinic acid Usage And Synthesis Chemical Properties Light yellow Cryst Uses 5-Bromopyridine-3-carboxylic acid (5-bromonicotinic acid) was used in the synthesis of 3-guanidinomethyl-5-iodopyridine. Synthesis Reference(s) Journal of the American Chemical Society, 70, p. 2381, 1948 DOI: 10.1021/ja01187a020 Purification Methods The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.]   5-Bromonicotinic acid Preparation Products And Raw materials Raw materials 3-Bromo-5-methylpyridine-->Methyl 5-bromonicotinate-->10-methoxy-1,6-dimethylergoline-8beta-methanol-->DIMETHYL 5-BROMOPYRIDINE-2,3-DICARBOXYLATE-->5-Bromonicotinamide-->2,4'-Dibromoacetophenone-->NICOTINYL CHLORIDE HYDROCHLORIDE-->3-Bromoquinoline-->3,5-Dibromopyridine Preparation Products 5-Aminonicotinic acid-->5-Fluoronicotinic acid-->5-AMINO-NICOTINIC ACID METHYL ESTER-->2-(5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)propan-2-ol-->(5-BROMO-PYRIDIN-3-YL)-ACETONITRILE-->3-BroMo-5-(prop-1-en-2-yl)pyridine-->3-Bromo-5-(Chloromethyl)Pyridine Hydrochloride-->3-Bromo-1,5-naphthyridine-->3-Amino-5-bromopyridine

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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