China Largest Factory Manufacturer sales 5-thio-D-glucose CAS 20408-97-3

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5-THIO-D-GLUCOSE Basic information Product Name: 5-THIO-D-GLUCOSE Synonyms: 5-Thio-α-D-glucopyranose;α-D-Glucothiopyranose;5-Thio-D-glucose,predominantly &-anomer;5-Thio-D-glucose, alpha-anomer;5-Thio-D-glucose ,98%;NSC 204984;5-Thio-D-glucose, ≥98.0% (HPLC);(2R,3R,4S,5R)-2,3,4,6-Tetrahydroxy-5-mercaptohexanal CAS: 20408-97-3 MF: C6H12O5S MW: 196.22 EINECS: 243-798-8 Product Categories: 13C & 2H Sugars;Carbohydrates & Derivatives;Sulfur & Selenium Compounds;Biochemicals and Reagents;Carbohydrates;Monosaccharide Mol File: 20408-97-3.mol   5-THIO-D-GLUCOSE Chemical Properties Melting point  135-138 °C(lit.) Boiling point  303.11°C (rough estimate) density  1.271 (estimate) refractive index  1.5060 (estimate) storage temp.  2-8°C solubility  Soluble in Water (up to 15 mg/ml) form  Powder pka 9.11±0.10(Predicted) color  White optical activity [α]/D 220.0±5.0°, c = 1 in 0.1 M HCl Water Solubility  Miscible with water. Merck  13,9408 BRN  1865193 Stability: Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 2 months. CAS DataBase Reference 20408-97-3 EPA Substance Registry System D-Glucose, 5-thio- (20408-97-3)   Safety Information Safety Statements  22-24/25 WGK Germany  3 RTECS  LZ7500000 F  3-10-23 MSDS Information   5-THIO-D-GLUCOSE Usage And Synthesis Description 5-Thio-D-glucose (20408-97-3) is a potent competitive inhibitor of the cellular transport of glucose and glucose-mediated insulin release.1 May be used to induce a state of glucose deprivation in laboratory animals.2 Stimulates feeding in rat models.3 Induces Alzheimer-like changes in frontal cortex and hippocampus in rats.4 Elevates renal TGF-b1 at a dose that does not prevent streptozotocin diabetes in rats.5 Uses 5-Thio-D-glucose (cas# 20408-97-3) is a compound useful in organic synthesis. References Wang et al. (1995) Glucose transporter 2 expression: prevention of streptozotocin-induced reduction in beta-cells with 5-thio-D-glucose; Clin. Endocrinol. Diabetes, 103 83 Suppl.2 Shah et al. (2019), Recurrent glucose deprivation leads to the preferential use of lactate by neurons in the ventromedial hypothalamus; J. Physiol. Endocrinol. Metab., 316 E948 Li et al. (2014), Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons; J. Physiol. Regul. Integr. Comp. Physiol., 306 R257 Salkovic-Petrisic et al. (2006), Alzheimer-like changes in protein kinase B and glycogen synthase kinase-3 in rat frontal cortex and hippocampus after damage to the insulin signaling pathway; J. Neurochem., 96 1005 Lane et al. (2000), 5-thio-D-glucose elevates renal transforming growth factor beta-1 at a dose that does not prevent streptozotocin diabetes in rats; Endocrinology, 141 3337   5-THIO-D-GLUCOSE Preparation Products And Raw materials

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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