China Largest Factory Manufacturer sales 2-Methylbenzene-1-sulfonamide/OTSA CAS 88-19-7

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2-Methylbenzene-1-sulfonamide Basic information Product Name: 2-Methylbenzene-1-sulfonamide Synonyms: 4-TOLUENESULFONIC ACID AMIDE;2-METHYLBENZENE-1-SULFONAMIDE;2-METHYLBENZENESULFONAMIDE;2-TOLUENESULFONAMIDE;TOLUENE-4-SULFONAMIDE;TOLUENE-4-SULPHONAMIDE;TOLUENE-2-SULFONAMIDE;2-methyl-benzenesulfonamid CAS: 88-19-7 MF: C7H9NO2S MW: 171.22 EINECS: 201-808-8 Product Categories: Pharmaceutical Intermediates;Aromatics, Impurities, Mutagenesis Research Chemicals, Sulfur & Selenium Compounds;Organics;Organic Building Blocks;Sulfonamides/Sulfinamides;Sulfur Compounds;SULFONAMIDE;Intermediates Mol File: 88-19-7.mol   2-Methylbenzene-1-sulfonamide Chemical Properties Melting point  156-158 °C (lit.) Boiling point  221 °C density  1.2495 (rough estimate) refractive index  1.6100 (estimate) Fp  178°C storage temp.  Sealed in dry,Room Temperature solubility  DMSO (Slightly), Methanol (Very Slightly, Heated) form  neat pka 10.17±0.60(Predicted) color  White to Off-White Water Solubility  Soluble in water (1.6 g/L at 25°C). BRN  1102362 InChIKey YCMLQMDWSXFTIF-UHFFFAOYSA-N CAS DataBase Reference 88-19-7(CAS DataBase Reference) NIST Chemistry Reference Benzenesulfonamide, 2-methyl-(88-19-7) EPA Substance Registry System Benzenesulfonamide, 2-methyl- (88-19-7)   Safety Information Hazard Codes  Xi,Xn Risk Statements  36-40 Safety Statements  26-36/37 WGK Germany  1 RTECS  XT5075000 TSCA  Yes HS Code  29350090 Hazardous Substances Data 88-19-7(Hazardous Substances Data) MSDS Information Provider Language 2-Methylbenzene-1-sulfonamide English SigmaAldrich English ACROS English ALFA English   2-Methylbenzene-1-sulfonamide Usage And Synthesis Chemical Properties 2-Methylbenzene-1-sulfonamide is Colorless crystals. Soluble in alcohol; slightly soluble in water and ether. Combustible. Uses 2-Methylbenzene-1-sulfonamide is a methylated sulfonamide and a major Impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity. Uses Plasticizer of thermosetting resin, as a raw material used in organic synthesis, preparation of nail polish, dyes, fluorescent pigments and coatings. Uses o-Toluenesulfonamide is a methylated sulfonamide and a major impurity if Saccharin (S080800). Studies suggest that o-Toluenesulfonamide has potential mutagenic activity. General Description Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. o-Toluenesulfonamide is a major impurity in artificial sweetening substances containing saccharin. Safety Profile Suspected carcinogen with experimental tumorigenic data. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as a chemical intermediate in the production of saccharin. Purification Methods Crystallise the amide from hot H2O (m 153o), then from EtOH or Et2O/pet ether. The N-o-toluenesulfonylphthalimide has m 182o (from EtOH). [Evans & Dehn J Am Chem Soc 51 3652 1929, Beilstein 11 H 86, 11 I 23, 11 II 39, 11 III 167, 11 IV 229.]   2-Methylbenzene-1-sulfonamide Preparation Products And Raw materials Raw materials Toluene-->Ammonium hydroxide-->Chlorosulfonic acid-->O-TOLUENESULFONYL CHLORIDE-->o-Methylphenyltrimethyltin(IV)-->2-Toluenesulfonyl isocyanate-->2-methylbenzenesulfinic acid-->TRIBUTYL(2-METHYLPHENYL)STANNANE-->Benzenediazonium, 2-methyl-, tetrafluoroborate(1-)-->O-TOLYLMAGNESIUM BROMIDE-->2-Methylbenzenethiol Preparation Products Chlorsulfuron-->Saccharin sodium-->2-CARBOXY PHENYLSULFAMIDE-->2-TOLUENESULFONIC ACID

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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