China Largest Factory Manufacturer sales 1,3,5-Tri-O-acetyl-2-deoxy-D-erythro-pentofuranose CAS 2595-5-3

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1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Basic information Synthesis Product Name: 1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Synonyms: 1,2:5,6-Di-O-isopropylidene-alpha-D-allo;1,2:5,6-Di-O-isoprop;1,2:5,6-Di-O-isopropylidene-α-D-allofuranose ,98%;1,2:5,6-Bis-O-(1-Methylethylidene)-α-D-allofuranose;1,2:5,6-Diacetone-D-allofuranose;Diacetone-D-allofuranose;1,2:5,6-Di-O-isopropylidene-alpha-D-ribo-hexofuranose;1,2:5,6-bis-O-(1-Methylethylidene)-alpha-D-Allofuranose CAS: 2595-05-3 MF: C12H20O6 MW: 260.28 EINECS:   Product Categories: 13C & 2H Sugars;Allose;Biochemistry;O-Substituted Sugars;Sugars;Carbohydrates & Derivatives;Sugars, Carbohydrates & Glucosides;Carbohydrate Synthesis;Monosaccharides;Specialty Synthesis Mol File: 2595-05-3.mol   1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Chemical Properties Melting point  73-76 °C(lit.) alpha  37.5 º (c=1,chloroform) Boiling point  363.54°C (rough estimate) density  1.2377 (rough estimate) refractive index  36.5 ° (C=1, CHCl3) storage temp.  Inert atmosphere,Store in freezer, under -20°C form  Powder pka 13.15±0.60(Predicted) color  White to off-white Stability: Acid Sensitive InChIKey KEJGAYKWRDILTF-BHRXDNSCSA-N CAS DataBase Reference 2595-05-3(CAS DataBase Reference)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  22-24/25-36/37-26 WGK Germany  3 F  21 HS Code  29400090 MSDS Information Provider Language ACROS English SigmaAldrich English   1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Usage And Synthesis Synthesis Anhydrous DMSO (650 mL) was cooled to 18−20 °C under nitrogen in a 3-L roundbottomed glass flflask. DMSO solidififies at 18 °C and therefore it is important to keep the reaction mixture just above freezing point. To this cold solution was added P2O5 (142 g, 1.0 mol, 1 equivalent) in 3 portions under a N2 atmosphere. The addition of P2O5 to DMSO is exothermic, and if the mass temperature exceeds 28 °C, the color darkens and the product will be of inferior quality. The mixture was cooled to 18−20 °C between each addition. After addition of P2O5 was completed, the mixture was stirred at 18−25 °C for 10−15 min. 1,2:5,6-Di-O-isopropylidene-D-glucofuranose (260 g, 1.0 mol) was dissolved in anhydrous DMSO (1.3 L) and added over 30 min (maintaining the temperature at 18−25 °C) to the stirred solution of P2O5 in DMSO under a N2 atmosphere. The resulting solution was heated to 50−55 °C for 3 h. TLC (eluent: CH2Cl2:MeOH, 95:5) shows complete conversion of glucofuranose (Rf = 0.68) to ulose (Rf = 0.81). The reaction mixture was allowed to reach 25−30 °C and was extracted twice with methyl tert-butyl ether (MTBE 1.5 and 1 L) in a 6-L separation funnel. The combined MTBE layer (~4 L) was concentrated in vacuo (water-bath temperature set to 40 °C) to approximately 2 L and allowed to reach 25−30 °C. NaBH4 (24 g, 0.63 mol) was dissolved in water (1 L, 55.6 mol) at 0−10 °C, and the concentrated MTBE layer was added to the aqueous layer over 30 min to keep  the temperature at 0−10 °C. TLC (eluent: EtOAc/heptane, 6:4) after 30 min shows  full conversion of ulose (Rf = 0.53) to 1,2:5,6-di-O-isopropylidene-D-allofuranose (Rf = 0.39). The reaction mixture was allowed to reach 25−30 °C. CH2Cl2 (1 L) and water (500 mL) were added, and the layers were separated. The aqueous layer was extracted once more with CH2Cl2 (500 mL). The combined organic layers were concentrated in vacuo to an oil which was subsequently dissolved in MTBE (300 mL) and extracted with water (3 × 500 mL). The combined aqueous layers were extracted with CH2Cl2 (3 × 500 mL). The combined CH2Cl2 layers were dried (Na2SO4, 100 g), fifiltered, and concentrated in vacuo to provide the crude oil. Crystallization from cyclohexane (500 mL), washing of crystals with cold n-pentane, and drying hereof in vacuo afforded analytically pure 1,2:5,6-di-O-isopropylidene-D-allofuranose (191 g, 73%). Reference: Christensen, S. M.; Hansen, H. F.; Koch, T. Org. Proc. Res. Dev. 2004, 8, 777−780. Chemical Properties White Solid Uses Protected α-D-Allofuranose   1,2:5,6-Di-O-isopropylidene-alpha-D-allofuranose Preparation Products And Raw materials Preparation Products 3-O-BENZYL-4-(HYDROXYMETHYL-1,2-O-ISOPROPYLIDENE)-ALPHA-D-ERYTHROPENTOFURANOSE

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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