China Largest Factory Manufacturer sales Thymol CAS 89-83-8

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Thymol Basic information Product Name: Thymol Synonyms: 2-Hydroxy-1-isopropyl-4-methylbenzene;2-isopropyl-5-methyl-pheno;2-Isopropyl-5-methylphenol (thymol);3-Hydroxy-1-methyl-4-isopropylbenzene;3-hydroxy-4-isopropyl-1-methylbenzene;3-hydroxy-p-cymen;3-methyl-6-(2-propyl)-phenol;3-Methyl-6-isopropylphenol CAS: 89-83-8 MF: C10H14O MW: 150.22 EINECS: 201-944-8 Product Categories: Biochemistry;Monocyclic Monoterpenes;Terpenes Mol File: 89-83-8.mol   Thymol Chemical Properties Melting point  48-51 °C(lit.) Boiling point  232 °C(lit.) density  0.965 g/mL at 25 °C(lit.) vapor pressure  1 mm Hg ( 64 °C) refractive index  nD20 1.5227; nD25 1.5204 FEMA  3066 | THYMOL Fp  216 °F storage temp.  2-8°C solubility  ethanol: soluble50mg/mL pka 10.59±0.10(Predicted) form  Crystals or Crystalline Powder color  White Odor Thyme-like odor PH Range 7 Water Solubility  0.1 g/100 mL (20 ºC) JECFA Number 709 Merck  14,9399 BRN  1907135 Stability: Stable. Incompatible with strong oxidizing agents, organic materials, strong bases. CAS DataBase Reference 89-83-8(CAS DataBase Reference) NIST Chemistry Reference Phenol, 5-methyl-2-(1-methylethyl)-(89-83-8) EPA Substance Registry System Thymol (89-83-8)   Safety Information Hazard Codes  C,N Risk Statements  22-34-51/53 Safety Statements  26-28-36/37/39-45-61-28A RIDADR  UN 3261 8/PG 3 WGK Germany  2 RTECS  XP2275000 TSCA  Yes HazardClass  8 PackingGroup  III HS Code  29071900 Hazardous Substances Data 89-83-8(Hazardous Substances Data) Toxicity LD50 orally in rats: 980 mg/kg (Jenner) MSDS Information Provider Language 5-Methyl-2-(1-methylethyl)phenol English ACROS English SigmaAldrich English ALFA English   Thymol Usage And Synthesis Chemical Properties white crystals or powder with a pungent odour Chemical Properties Thymol occurs as colorless or often large translucent crystals, or as a white crystalline powder with a herbal odor (aromatic and thymelike) and a pungent caustic taste. Chemical Properties Thymol is the main constituent of thyme and some origanum oils; it also occurs in many other essential oils. It forms colorless crystals (mp 51.5°C) with a spicy, herbal, slightly medicinal odor reminiscent of thyme. Thymol is prepared on a technical scale in a continuous high-temperature, high-pressure, liquid-phase, ortho-alkylation process, fromm-cresol and propylene, in the presence of activated aluminumoxide hydrate. The crude thymol mixture, consisting of approximately 60% thymol, unreacted m-cresol (about 25%), and other (iso)propyl-substituted products, is separated by fractional distillation. Most of the by-products are recycled. Thymol is used as a dry top note in lavender compositions, in men’s fragrances, and as a disinfectant in oral care products. It is also important as a startingmaterial for the production of racemic menthol. Anethole is used in large quantities in the alcoholic beverage industry and in oral hygiene products. Some crude anethole is converted into anisaldehyde. Chemical Properties Thymol has a characteristic herbaceous, warm and aromatic odor with a sweet, medicinal, spicy flavor Occurrence Reported in the essential oils of Monarda punctata, Satureia thymera, Origanum floribundum, Ocimum viride, Ocimum gratissimum and particularly in thyme (Thymus vulgaris L., T. capitatus, T. serpillum L.), where it is contained up to 50%. Also reported found in citrus peel oils, orange and tangerine juice, bilberry, cranberry, blueberry, papaya, blackberry, celery seed, chive, clove bud, cumin seed, ginger, peppermint oil, corn mint oil, Scotch spearmint oil, nutmeg, parsley, thyme, Gruyere cheese, parmesan cheese, romano cheese, white wine, black tea, plum, sweet and wild marjoram, fenugreek, mango, cardamom, dill herb and seed, licorice, lovage leaf, buckwheat, sweet corn, elder flower, cherimoya, rosemary, lemon balm, Spanish sage, anise hyssop, sweet grass oil, eucalyptus oil and mastic gum oil. Uses Thymol is used as a preservative in halothane. It acts as an anesthetic, antiseptic in mouth wash, stabilizer in pharmaceutical preparations. It inhibits the growth and lactate production as well as reduces the uptake of cellular glucose within the bacteria. It is an active ingredient in toothpastes like euthymol. It is involved to control varroa mites and prevent fermentation and the growth of mold in bee colonies. Uses Thymol is an antimicrobial compound which can increase the efficacy of antibiotics involving drug resistant bacteria. It inhibits growth and lactate production as well as reduces cellular glucose upta ke within the bacteria. Production Methods Thymol is obtained from the volatile oil of thyme (Thymus vulgaris Linne′ (Fam. Labiatae)) by fractional distillation followed by extraction and recrystallization. Thyme oil yields about 20–30% thymol. Thymol may also be produced synthetically from pcymene, menthone, or piperitone, or by the interaction of m-cresol with isopropyl chloride. Definition thymol: A pungent-smelling colourless crystalline compound, C10H14O;m.p. 51°C. It occurs in various essentialoils, particularly oil of thyme,and can be made by using iron(III)chloride to oxidize piperitone (itselfextracted from eucalyptus oil). Itsantiseptic properties are exploited ingargles and mouthwashes. Aroma threshold values Detection: 86 to 790 ppb Taste threshold values Phenolic, medicinal, woody and spicy General Description Thymol is a monoterpene phenol derivative. It is a key volatile aroma constituent of the essential oil of plants such as thyme, basil, and oregano. It has strong antioxidant, antibacterial, anticarcinogenesis, anti-inflammatory, and antiseptic properties. Pharmaceutical Applications Thymol is a phenolic antiseptic, which has antibacterial and antifungal activity. However, it is not suitable for use as a preservative in pharmaceutical formulations because of its low aqueous solubility. The antimicrobial activity of thymol against eight oral bacteria has been studied in vitro. Inhibitory activity was noted against almost all organisms, and a synergistic effect was observed for combinations of thymol and eugenol, and of thymol and carvacrol. The activity of thymol against bacteria commonly involved in upper respiratory tract infections has also been shown. Thymol is a more powerful disinfectant than phenol, but its low water solubility, its irritancy to tissues, and its inactivation by organic material, such as proteins, limit its use as a disinfectant. Thymol is chiefly used as a deodorant in antiseptic mouthwashes, gargles, and toothpastes, such as in Compound Thymol Glycerin BP, in which it has no antiseptic action. Thymol is also a true antioxidant and has been used at concentrations of 0.01% as an antioxidant for halothane, trichloroethylene, and tetrachloroethylene. The antioxidant activity of thymol and thymol analogues has been described. More recently, thymol has been shown to enhance the in vitro percutaneous absorption of a number of drugs, including 5- fluorouracil, piroxicam, propranolol, naproxen, and tamoxifen. Studies have also demonstrated that the melting point of lidocaine is significantly lowered when it is mixed with thymol. The inhalation of thymol, in combination with other volatile substances, is used to alleviate the symptoms of colds, coughs, and associated respiratory disorders. Externally, thymol has been used in dusting powders for the treatment of fungal skin infections; thymol has been shown to have synergistic antifungal effects when combined with ketoconazole. Thymol was formerly used in the treatment of hookworm infections but has now been superseded by less toxic substances. In dentistry, thymol has been mixed with phenol and camphor to prepare cavities before filling, and mixed with zinc oxide to form a protective cap for dentine. Thymol has been included in food, perfume, and cosmetic products, and has also been used as a pesticide and fungicide. Biochem/physiol Actions Taste at 5 ppm Clinical Use Isopropyl m-cresol is extracted from oil of Thymus vulgaris(thyme, of the mint family) by partitioning into alkalineaqueous medium followed by acidification. The crystals obtainedfrom the mother liquor are large and colorless, with athymelike odor. Thymol is only slightly soluble in water,but it is extremely soluble in alcohols and other organic solvents.Thymol has mild fungicidal properties and is used inalcohol solutions and in dusting powders for the treatmentof tinea (ringworm) infections. Safety Profile Poison by ingestion and intravenous routes. Moderately toxic by subcutaneous route. Experimental reproductive effects. Mutation data reported. An allergen. Incompatible with acetanilide. When heated to decomposition it emits acrid smoke and irritating fumes. An FDA over-the-counter drug used as an antibacterial and antifungal agent. Safety Thymol is used in cosmetics, foods, and pharmaceutical applications as an excipient. However, thymol may be irritating when inhaled or following contact with the skin or eyes. It may also cause abdominal pain and vomiting, and sometimes stimulation followed by depression of the central nervous system following oral consumption; fats and alcohol increase absorption and aggravate symptoms. Respiratory arrest, attributed to acute nasal congestion and edema, has been reported in a 3-week-old patient due to the erroneous intranasal application of Karvol, a combination product that includes thymol. The patient recovered, but it was recommended that inhalation decongestants should not be used in children under the age of 5 years. LD50 (guinea pig, oral): 0.88 g/kg LD50 (mouse, IP): 0.11 g/kg LD50 (mouse, IV): 0.1 g/kg LD50 (mouse, oral): 0.64 g/kg LD50 (mouse, SC): 0.243 g/kg LD50 (rat, oral): 0.98 g/kg storage Thymol should be stored in well-closed, light-resistant containers, in a cool, dry, place. Thymol is affected by light. Incompatibilities Thymol is incompatible with iodine, alkalis, and oxidizing agents. It liquefies, or forms soft masses, on trituration with acetanilide, antipyrine, camphor, monobromated camphor, chloral hydrate, menthol, phenol, or quinine sulfate. The antimicrobial activity of thymol is reduced in the presence of proteins. Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (inhalation, liquid; oral, powder for solution). Included in nonparenteral medicines (topical creams and ointments) licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.   Thymol Preparation Products And Raw materials Raw materials m-Cresol-->Cresol-->2-Chloropropane-->Thyme Oil-->Phenol oil-->2,4-Diisopropyl-5-methylphenol-->thymol acetate-->5-methyl-2-(prop-1-en-2-yl)phenol-->4-CHLORO-2-ISOPROPYL-5-METHYLPHENOL-->6-tert-Butyl-m-cresol-->2-Cyclohexen-1-one, 6-hydroxy-3-methyl-6-(1-methylethyl)- Preparation Products L-Menthol-->leather seasoning agent DLC-1-->Carvacrol-->Thymolphthalein-->DL-Menthol-->4-ISOPROPYL-3-METHYLPHENOL-->2,4-Dibromo-6-isopropyl-3-methylphenol-->Phenol, 2-bromo-3-methyl-6-(1-methylethyl)-

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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