China Largest Factory Manufacturer sales Calcium acetate CAS 62-54-4

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Calcium acetate Basic information Chemical properties Uses Toxicity Usage limit Production method Hazards & Safety Information Product Name: Calcium acetate Synonyms: acetatedecalcium;Aceticacid,calciunsalt;teltozan;vinegarsalts;CALCIUM ACETATE EXTRA PURE, FCC, E 263;CALCIUM ACETATE HYDRATE PURE;CALCIUM ACETATE HYDRATE, 99.99%;CALCIUM ACETATE SIGMAULTRA CAS: 62-54-4 MF: C4H6CaO4 MW: 158.17 EINECS: 200-540-9 Product Categories: Organic chemistry;Pyridines;metal acetate salt;Food additive;food stabilizer,corrosion inhibitor;other chemicals Mol File: 62-54-4.mol   Calcium acetate Chemical Properties Melting point  160°C (dec.) density  1,5 g/cm3 refractive index  1.5500 FEMA  2228 | CALCIUM ACETATE Fp  160°C storage temp.  Hygroscopic, Room Temperature, under inert atmosphere solubility  H2O: 1 M at 20 °C, clear, colorless form  Powder Specific Gravity 1.50 color  white PH 8(1 mM solution);8.43(10 mM solution);8.77(100 mM solution);9.13(1000 mM solution) Water Solubility  soluble Decomposition  160 ºC Stability: Stable. Non-flammable. Incompatible with strong oxidizing agents. InChIKey VSGNNIFQASZAOI-UHFFFAOYSA-L CAS DataBase Reference 62-54-4(CAS DataBase Reference) EPA Substance Registry System Calcium acetate (62-54-4)   Safety Information Hazard Codes  Xi Risk Statements  36/37/38 Safety Statements  26-36 WGK Germany  1 RTECS  AF7525000 TSCA  Yes HS Code  29152990 Hazardous Substances Data 62-54-4(Hazardous Substances Data) MSDS Information Provider Language Acetic acid calcium salt English SigmaAldrich English ALFA English   Calcium acetate Usage And Synthesis Chemical properties Calcium acetate, also known as acetate of lime or vinegar salts, is the calcium salt of acetic acid. It is an odorless powder. Calcium has an important role in the nutrition of humans and animals. Hormonal mechanisms control absorption of dietary calcium (including added calcium salts) allowing adaptation to a range of calcium intakes while maintaining a relatively constant blood calcium concentration of about 10 mg/100 mL. Major functions of calcium inside the body include the formation and maintenance of bones and teeth, the physiology of muscle contraction, the cell membrane integrity, the activity of several enzymes that have specific requirement for it, the coagulation of blood, and the regulation of acid-base balance.* Uses Calcium acetate [Ca(CH3COO)2.H2O] is used as a food additive and a mordant to fix dyes in the textile industry. It is used as an alkali (base) in the manufacture of soaps, to improve some lubricants, and as an antimold to preserve baked goods for a longer shelf life. Toxicity ADI is not subject to restrictive regulations (FAO/WHO, 2001). GRAS (FDA, §181.29, §182.6197, § 184.1185, 2000). LD50: 52 mg/kg (mouse, subcutaneous). Usage limit GB 14880 a 94: cereals and their products, beverages 8~16g/kg. GB 2760-2001: vinegar, 6~8g/kg (in terms of Ca). FAO/WHO (1984): Edible caseinate, GMP. FDA, § 184.1185 (2000): baked goods, gelatin, pudding, fillings, 0.2%; sweet sauce, top materials and poured, 0.15%; EEC can be used for packaging cheese powder, quick-setting jelly powder. FEMA (mg/kg): soft drinks 200; baked goods 500. Production method It is obtained by the reaction between calcium carbonate and acetic acid. Preparation method of anhydrous calcium acetate: the refined powder of calcium carbonate is added to the water, stirred into a suspension; added separately of a small amount of glacial acetic acid. After completion of the reaction, the filtrate was concentrated in a water bath and a white solid, anhydrous calcium acetate, was precipitated from the viscous filtrate. It is obtained by the neutralization between coke acid (wood acetic acid) and calcium hydroxide, followed by the evaporation of the filtrate and recrystallization. It is obtained by the reaction between the reaction between acetic acid and calcium hydroxide or calcium carbonate. Filter, concentrate and cool to obtain the dihydrate (colorless crystal), heated to 84 °C in a water salt (colorless crystal), heated to 100 °C to obtain the anhydrous salt. Shellfish can be taken as raw materials, washed, crushed and dried for 1 h, subjecting to barbecue for 2 hour at 900~l000 ℃, then being added water to make a 1.3~1.5mol/L lime milk. And then neutralized with acetic acid to clarify, filter with the filtrate concentrated, and finally dried at 120~140 °C to get the final product with a yield of 91.28%. To a 20% acetic acid solution, add calcium carbonate powder to until there is no longer any CO2 gas escaping, then add a small amount of calcium carbonate, heated  80 ° C for reaction of 2-3h. The filtrate was heated and concentrated with water bath while adding a small amount of 80% acetic acid at the same time to precipitate the calcium acetate monohydrate (what precipitated after the cooling of the solution is dihydrate), and finally dried at 60~70 ℃to derive the products. Hazards & Safety Information Category:  Toxic substances Toxicity classification:  highly toxic Acute toxicity:  intravenous-mouse LD50: 52 mg/kg; celiac-mouse LD50: 75 mg/kg Flammability and Hazardous characteristics:  Thermal decomposition releases Pungent irritation Smoke Storage and transportation characteristics:Treasury: ventilated, low temperature drying; store it separately from food raw materials Fire extinguishing agent:  water, dry powder, foam, carbon dioxide Description Calcium acetate is a chemical compound which is calcium salt of acetic acid. It has the formula Ca(C2H3O2)2. Its standard name is calcium acetate, while calcium ethanoate is the systematic name. An older name is acetate of lime. The anhydrous form is very hygroscopic; therefore the monohydrate (Ca(CH3COO)2 H2O) is the common form. Chemical Properties Calcium acetate occurs as a white or almost white, odorless or almost odorless, hygroscopic powder. Uses Calcium Acetate is the calcium salt of acetic acid which functions as a sequestrant and mold control agent. it contains approximately 25% calcium. it is a white odorless powder which is readily soluble in water with a solubility of approximately 37 g in 100 g water at 0°c. its solubility decreases with increasing temperature, with a sol- ubility of approximately 29 g in 100 g of water at 100°c. Uses Calcium Acetate is the salt of acetic acid which is used as a preservative and sequestrant. Uses Calcium Acetate is a salt of acetic acid (A167640), a common chemical reagent used in a multitude of organic reactions. It is the primary constituent of vinegar, contributing to its distinct taste and odor. It is used in the synthesis of dye-sensitized solar cells. Production Methods Calcium acetate can be prepared by soaking calcium carbonate (found in eggshells, or in common carbonate rocks such as lime stone or marble) in vinegar: CaCO3 + 2CH3COOH → Ca(CH3COO)2 + H2O + CO2 Since both reagents would have been available pre-historically, the chemical would have been observable as crystals then. Preparation Produced by calcium hydroxide neutralization of acetic acid. Definition ChEBI: The calcium salt of acetic acid. It is used, commonly as a hydrate, to treat hyperphosphataemia (excess phosphate in the blood) in patients with kidney disease: the calcium ion combines with dietary phosphate to form (insoluble) calcium phosphate, which is excreted in the faeces. General Description Calcium Acetate belongs to the group of calcium salts, widely used as phosphorus binders in patients with chronic renal failure. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pharmaceutical Applications Calcium acetate is used as a preservative in oral and topical formulations. Therapeutically, parenteral calcium acetate acts as a source of calcium ions for hypocalcemia or electrolyte balance. Oral calcium acetate is used as a complexing agent for hyperphosphatemia in dialysis patients. Calcium acetate is also used in the food industry as a stabilizer, buffer and sequestrant. Clinical Use Phosphate binding agent Safety Profile Poison by intravenous and intraperitoneal routes. Mutation data reported. See also CALCIUM COMPOUNDS. When heated to decomposition it emits acrid smoke and fumes. Safety Calcium acetate is used in oral and topical formulations. The pure form of calcium acetate is toxic by IP and IV routes. LD50 (mouse, IP): 0.075 g/kg LD50 (mouse, IV): 0.052 g/kg LD50 (rat, oral): 4.28 g/kg Veterinary Drugs and Treatments Calcium acetate can be used for oral administration to treat hyperphosphatemia in patients with chronic renal failure. Secondary to its phosphorus binding efficiency and lower concentration of elemental calcium, calcium acetate is considered the most effective and having the lowest potential for causing hypercalcemia of the calcium-based phosphorus-binding agents. When compared to calcium carbonate, calcium acetate binds approximately twice as much phosphorus per gram of elemental calcium administered. Unlike calcium citrate, calcium acetate does not promote aluminum absorption. Drug interactions Potentially hazardous interactions with other drugs Can impair absorption of some drugs, e.g. iron, ciprofloxacin. Metabolism The residual acetate will be metabolised through bicarbonate, which will be further excreted via normal metabolic routes. Any unbound calcium not involved in the binding of phosphate will be variable and may be absorbed. Calcium is absorbed mainly from the small intestine by active transport and passive diffusion. About one-third of ingested calcium is absorbed although this can vary depending upon dietary factors and the state of the small intestine. 1,25-Dihydroxycholecalciferol (calcitriol), a metabolite of vitamin D, enhances the active phase of absorption. Excess calcium is mainly excreted renally. Unabsorbed calcium is eliminated in the faeces, together with that secreted in the bile and pancreatic juice. Minor amounts are lost in the sweat, skin, hair, and nails. storage Calcium acetate is stable although very hygroscopic, and so the monohydrate is the common form. It decomposes on heating (above 1608℃) to form calcium carbonate and acetone. Store in well-closed airtight containers. Purification Methods Recrystallise it from water (3mL/g) by partial evaporation in a desiccator. [Beilstein 2 IV 113.] Incompatibilities Calcium acetate is incompatible with strong oxidizing agents and moisture. Regulatory Status GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral suspensions and tablets; topical emulsions, lotions, and creams). Included in nonparenteral medicines (oral tablets) licensed in the UK.   Calcium acetate Preparation Products And Raw materials Raw materials Acetic acid-->Calcium carbonate-->Calcium hydroxide-->Calcium oxide-->CALCIUM CARBONATE-->Sodium molybdate dihydrate-->PYROLIGNEOUS ACID-->Calcium acetate monohydrate-->Calcium nitrate tetrahydrate-->Amyl acetate Preparation Products Acetone-->Sodium acetate-->Acetophenone-->Acetaldehyde-->Calcium fluoride-->2-Pentanone-->Chorionic Gonadotropin-->3-Acetylpyridine

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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