China Largest Factory Manufacturer sales 2-Naphthol CAS 135-19-3

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2-Naphthol Basic information Chemical Properties Application Preparation Product Name: 2-Naphthol Synonyms: c.i.37500;c.i.azoiccouplingcomponent1;c.i.developer5;Developer A;Developer AMS;Developer BN;developera;developerams CAS: 135-19-3 MF: C10H8O MW: 144.17 EINECS: 205-182-7 Product Categories: Fluorescent;Naphthalene;Color Former & Related Compounds;alcohol;MICROCIDIN;pigments;Intermediates;Aromatic Compounds;Developer;Functional Materials;Alphabetical;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;Dyestuff Intermediates;Aromatics;C9 to C20+;Cell Biology;Chemical Synthesis;Fluorescent Indicators and Probes;Fluorescent Probes;Labels;N;Organic Building Blocks;Oxygen Compounds;Particles and Stains;pH Sensitive Probes and Indicators;Phenols Mol File: 135-19-3.mol   2-Naphthol Chemical Properties Melting point  120-122 °C(lit.) Boiling point  285-286 °C(lit.) density  1,28 g/cm3 vapor density  4.97 (vs air) vapor pressure  10 mm Hg ( 145.5 °C) refractive index  1.5762 (estimate) Fp  153 °C storage temp.  Store below +30°C. solubility  methanol: soluble1g/10 mL, clear, colorless to light yellow pka 9.51(at 25℃) form  Powder, Crystals or Granules color  White PH Range Non& uorescence (8.5) to blue & uorescence (9.5) Water Solubility  1 g/L (20 ºC) λmax 226nm, 265nm, 275nm, 286nm, 320nm, 331nm Merck  14,6384 BRN  742134 Stability: Stable. Combustible. Dust may form explosive mixture with air. Incompatible with strong oxidizing agents, phenol. Major Application Display device, semiconductors, photoimaging materials, inks, toner, chalk, security paper, molding materials, tin plating method, rubber, adhesive, leather, detergent, hair dyes, antimitotic drug, anticancer agent, antiinflammatory agent, treatment of acne vulgaris (pimples) and other dermal ailments (rashes, scratches, blemishes, hair loss), disorders InChIKey JWAZRIHNYRIHIV-UHFFFAOYSA-N CAS DataBase Reference 135-19-3(CAS DataBase Reference) NIST Chemistry Reference 2-Naphthalenol(135-19-3) EPA Substance Registry System 2-Naphthalenol (135-19-3)   Safety Information Hazard Codes  Xn,N Risk Statements  20/22-50 Safety Statements  24/25-61 RIDADR  UN 3077 9/PG 3 WGK Germany  2 RTECS  QL2975000 F  8 Autoignition Temperature 430 °C TSCA  Yes HazardClass  9 PackingGroup  III HS Code  29071590 Hazardous Substances Data 135-19-3(Hazardous Substances Data) Toxicity LD50 orally in Rabbit: 1960 mg/kg LD50 dermal Rabbit > 10000 mg/kg MSDS Information Provider Language Naphthyl alcohol English SigmaAldrich English ACROS English ALFA English   2-Naphthol Usage And Synthesis Chemical Properties White lustrous leaflets or white powder. Insoluble in water, soluble in ethanol, ether, chloroform, glycerol, and alkaline solutions. Application It is used to produce Tobias acid, J acid, 2-hydroxy-3-naphthoic acid and azo dyes, and it is the raw material for rubber antioxidants, mineral dressing agents, fungicides, antiseptics, preservatives, etc. As feed preservative. In China, it can be used for citrus preservation, the maximum dosage amount is 0.1 g/kg and the residue amount should be no more than 70 mg/kg. 2-Naphthol, also called ß-naphthol, 2-naphthalenol, is the intermediate for plant growth regulator, 2-naphthoxyacetic acid. As analytic agent, absorbent of ethylene and carbon monoxide, and fluorescence indicator. Important organic raw material and dye intermediate, used to produce Tobias acid, butyric acid, β-hydroxynaphthoic acid and used to produce N-phenyl-2-naphthylamine, Diafen NN and other antioxidant, organic pigments, and fungicides. For the detection of bromine, chlorine, chlorate, niobium, copper, nitrite, and potassium. Substrate for fluorometric assay of phenol sulfotransferase. Acid and alkali indicator, dyes, organic synthesis, qualitative determination of allyl alcohol, methanol, chloroform, etc. Absorbent of carbon monoxide, ethanol, and fluorescence indicator. Determination of carbon monoxide, copper, nitrite, and potassium. Ethylene absorbent. Preparation (1) Sulfonation alkali melting method Obtained by sulfonation of naphthalene and alkali melting. Sulfonation alkali melting 2-naphthol synthesis process is widely used in both domestic and foreign production, but it is with serious corrosion, high cost, large amount of waste water and high biological oxygen consumption. American Cyanamid Company developed 2-isopropyl-naphthalene method with naphthalene and propylene as the raw materials, which produces 2-naphthol and with byproduct acetone. This method is similar to Cumene process to produce phenol. The consumed amount of raw materials: 1170 kg/t refined naphthalene, 1080 kg/t sulfuric acid, 700 kg/t sodium hydroxide (caustic soda). Details: Refined naphthalene was put into the sulfonation kettle and heated up to 140°C (melting). Sulfuric acid (sulfuric acid/refined naphthalene (mol/mol=1.8) was added within 20 minutes. The temperature was raised up to 160-164°C and kept for 2.5 h. The reaction was terminated when the content of 2-naphthalenesulfonic acid is above 66% and the total acidity is 25%-27%. The sulfonates were hydrolyzed for 1 h at 140-150°C inside a hydrolysis kettle. Following neutralization at 80-90°C with sodium nitrite solution was performed until the Congo red test paper was no more blue. Steam and air were used to remove SO2 gas. When the temperature was cooled down to 30-40°C, vacuum filtration was applied. After washing with salt water (10%) and following vacuum filtration, 2-naphthalenesulfonic acid sodium salt was obtained. Sodium hydroxide was put into an alkali melting kettle and heated to 290°C (melting). At about 3 hours 2-naphthalenesulfonic acid sodium salt was added until the freebase content was 5%-6%. Afterwards, the temperature was kept at 320-330°C for 1 hour. The alkali melt was diluted with water and SO2 gas was passed at 70-80°C until phenolphthalein did not show any color. Addition of water to boil and wash, sodium sulfite was removed, dehydration and then under reduced pressure to distill the final product. The total yield is 73%-74%. (2) 2-isopropyl-naphthalene method. With naphthalene and ethylene as the raw materials to produce 2-naphthaol with byproduct acetone. Details: Sulfuric acid was added into the melted naphthalene at 140℃ and the sulfonation was carried out at 162-164°C. The sulfonates were hydrolyzed, the free naphthalene was blown away and sodium sulfite was added to react and generate 2-naphthalenesulfonic acid sodium salt. This salt together with sodium hydroxide were alkali melted at 285-320°C and kept at 320-330°C for 1 hour. After the dilution of this alkali melt, acidification with SO2 gas was performed to obtain crude products. Followed washing, dehydration and distillation were carried out to obtain the final products. Chemical Properties white or off-white powder with a slight Chemical Properties 2-Naphthol is a white, crystalline solid. Slight phenolic odor. Darkens in air and on exposure to light. Uses Has been used as antiseptic, anthelmintic and counter-irritant in alopecia. Uses anthelmintic, antiseptic Uses 2-Naphthol is used in the manufacture of dyes, perfumes, and medicinal organics, and in the production of antioxidants for synthetic rubber. Preparation products were made Naphthalen-2-ol, and sodium hydroxide melting, finally using hydrochloric acid or carbon dioxide exhalation. Definition ChEBI: A naphthol carrying a hydroxy group at position 2. Synthesis Reference(s) Journal of the American Chemical Society, 72, p. 4884, 1950 DOI: 10.1021/ja01167a009 Synthesis, p. 437, 1985 DOI: 10.1055/s-1985-31235 General Description 2-Naphthol (2OH) is a hydroxyarene molecule, which when electronically excited forms strong acid. Excited 2OH dissociates only in water. It has a slight phenolic odor. It is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides. It is one of the most commonly used fluorescence dye. Hazard See α-naphthol Health Hazard Although the toxicity of 2-naphthol is of low order in test animals, ingestion of large amounts may result in nausea, vomiting, diarrhea, abdominal pain, convulsions, and hemolytic anemia. Death may result from respiratory failure. The oral LD50 value in rats is in the range 2000 mg/kg. 2-Naphthol is slightly more toxic than 1-naphthol [9015-3], the oral LD50 value of which is in the range 2500 mg/kg. Skin contact can produce peeling of the skin and pigmentation. Fire Hazard Noncombustible solid. Safety Profile Poison by ingestion, inhalation, and subcutaneous routes. Mutation data reported. A skin and eye irritant. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical. Incompatible with antipyrine, camphor, phenol, ferric salts, menthol, potassium permanganate and other oxidzing materials, urethane. Potential Exposure A potential danger to those involved in rubber antioxidant production, synthesis of dyes; leather processing; fungicides, pharmaceuticals, and perfumes. Used as an antioxidant for fats, oils; as an antiseptic; in insecticides. Shipping UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard Class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. Properties and Applications white crystalline, with phenol smell. Industrial goods for hoar chip or powder. Melting point 121 ~ 123 ℃, 285 ℃ ~ 286 boiling point, flash point 161 ℃. This product soluble in water, ethanol, ethyl ether, chloroform, glycerin and alkali solution, can the sublimation, with steam evaporate out; Long storage or light color in turn dark, can happen oxidation, reduction, nitrification and nitrosation reaction, and products, light and heat, halogenating role, etc. Purification Methods Crystallise 2-naphthol from aqueous 25% EtOH (charcoal), H2O, *benzene, toluene or CCl4. Alternatively, extract it repeatedly with small amounts of EtOH, followed by dissolution in a minimum volume of EtOH and precipitation with distilled water, then drying over P2O5 under vacuum. It has also been dissolved in aqueous NaOH and precipitated by adding acid (repeat several times), then precipitated from *benzene by addition of heptane. Final purification can be by zone melting or sublimation in vacuo. The 4-nitrobenzoate has m 104o (from EtOH). [Bardez et al. J Phys Chem 89 5031 1985, Kikuchi et al. J Phys Chem 91 574 1987, Beilstein 6 IV 4253.] Incompatibilities Dust or powder may form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron salts; 2,3-dimethyl-1- phenyl-3-pyrazolin-5-one (antipyrine); camphor, phenol, menthol, urethane. Waste Disposal Mix with flammable solvent and atomize into an incinerator.   2-Naphthol Preparation Products And Raw materials Raw materials Sodium hydroxide-->Sulfuric acid-->Nitric acid-->Sodium sulfite-->Sulfur dioxide-->Naphthalene-->Congo red paper-->Naphthalene-2-sulfonic acid-->Phenolphthalein-->Sodium 2-naphthalenesulfonate Preparation Products 2-Naphthylamine-->(R)-(+)-1,1'-Bi-2-naphthol-->Pigment Red 21-->2-Aminonaphthalene-1-sulfonic acid-->NAPROANILIDE-->(S)-(-)-1,1'-Bi-2-naphthol-->1-Amino-2-naphthol-4-sulfonic acid-->Indigo Carmine-->3-Hydroxy-2-naphthoic acid-->2-FLUORONAPHTHALENE-->2-Acetyl-6-methoxynaphthalene-->Eriochrome Black T-->6-HYDROXY-2-NAPHTHALENEBORONIC ACID-->Disodium 2-naphthol-3,6-disulfonate-->1-Diazo-2-naphthol-4-sulfonic acid-->6-Amino-4-hydroxy-2-naphthalenesulfonic acid-->Lithol Red-->Pigment Red 53:1-->Pigment Orange 5-->Pigment Red 4-->Pigment Red 3-->Mordant Black 17-->Naproxen-->synthetic tanning agent HV-->Neutral Black 2S-RL-->Acid Black 168-->2-Naphthaleneboronic acid-->2-HYDROXY-1-NAPHTHOIC ACID-->Sodium 6-hydroxynaphthalene-2-sulfonate-->N-(2-Naphthyl)aniline-->synthetic tanning agent PNC-->2-Amino-3,6,8-naphthalenetrisulfonic acid-->ACID BLUE 161, PURE-->Eriochrome Black A-->synthetic tanning agent No.9

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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