China Largest Factory Manufacturer sales Camphor CAS 76-22-2

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Camphor Basic information Description Uses Dosage Interactions Side Effects Warning Product Name: Camphor Synonyms: CAMPHOR SQUARES SYNTHETIC TECHNICAL;CAMPHOR SYNTHETIC FLAKES;CAMPHOR SYNTHETIC POWDER;CAMPHOR TECH. GRADE;1,7,7-trimethyl-bicyclo(2.2.1)heptan-2-on;1,7,7-trimethylbicyclo[2.2.1]-2-heptanone (camphor);1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-on;1,7,7-trimethyl-norcampho CAS: 76-22-2 MF: C10H16O MW: 152.23 EINECS: 200-945-0 Product Categories: Bicyclic Monoterpenes;Biochemistry;Camphor, etc. (Plasticizer);Functional Materials;Plasticizer;Terpenes;FINE Chemical & INTERMEDIATES;Miscellaneous Natural Products;ketone;Inhibitors Mol File: 76-22-2.mol   Camphor Chemical Properties Melting point  175-177 °C(lit.) Boiling point  204 °C(lit.) density  0.992 vapor density  5.2 (vs air) vapor pressure  4 mm Hg ( 70 °C) refractive index  1.5462 (estimate) FEMA  4513 | dl-CAMPHOR Fp  148 °F storage temp.  Store below +30°C. solubility  Soluble in acetone, ethanol, diethylether, chloroform and acetic acid. form  neat optical activity [α]20/D +0.15 to -0.15°, c = 10% in ethanol explosive limit 0.6-4.5%(V) Water Solubility  0.12 g/100 mL (25 ºC) Merck  14,1732 JECFA Number 2199 BRN  1907611 Henry's Law Constant (x 10-5 atm m3/mol): 3.00 at 20 °C (approximate - calculated from water solubility and vapor pressure) Exposure limits TLV-TWA 12 mg/m3 (2 ppm), STEL 18 mg/m3 (3 ppm) (ACGIH); IDLH 200 mg/m3 (NIOSH). . Stability: Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics. InChIKey DSSYKIVIOFKYAU-MHPPCMCBSA-N CAS DataBase Reference 76-22-2(CAS DataBase Reference) NIST Chemistry Reference Camphor(76-22-2) EPA Substance Registry System Camphor (76-22-2)   Safety Information Hazard Codes  F,Xn,Xi Risk Statements  11-22-36/37/38-20/21/22 Safety Statements  16-26-37/39 RIDADR  UN 2717 4.1/PG 3 WGK Germany  1 RTECS  EX1225000 Autoignition Temperature 870 °F TSCA  Yes HazardClass  4.1 PackingGroup  III HS Code  29142910 Hazardous Substances Data 76-22-2(Hazardous Substances Data) Toxicity LD50 orally in mice: 1.3 g/kg (PB293505) IDLA 200 mg/m3 MSDS Information   Camphor Usage And Synthesis Description Camphor is a white, waxy organic compound that is incorporated in lotions, ointments, and creams. Camphor is also an active ingredient that is integrated into a majority of over-the-counter medications for cold and cough relief. Camphor oil is obtained from camphor tree wood, where the extract is processed through steam distillation. It has a pungent odor and a strong taste, and it can be absorbed into the skin easily. Currently, synthetic camphor is extracted from turpentine, and it is considered safe for use as long as appropriate indications are upheld. Uses Camphor has a wide range of uses based on its anti-inflammatory, anti-fungal, and anti-bacterial properties. It can be used for the treatment of certain skin conditions, enhance respiratory function and as a pain reliever. Camphor may also be indicated for the treatment of low libido, muscle spasms, anxiety, depression, flatulence, and poor blood circulation, corns, symptoms of heart disease, cold sores, earaches, acne, and hair loss. Camphor is considered effective for coughs, pain, skin irritation or itching relief, and osteoarthritis. However, there is insufficient evidence that reinforces its effectiveness as a treatment for hemorrhoids, warts, and low blood pressure and as a remedy for insect bites. Dosage The topical dose of camphor is 3-11% as an ointment. For skin irritation, itching and pain, 3-11% of the ointment should be applied to the skin 3-4times per day. For coughs and cold relief, a dense layer of 4.7-5.3% of Camphor ointment can be spread evenly onto the chest. For Osteoarthritis, a topical combination comprising 32mg/g of camphor, 50mg/g of chondroitin sulfate, and 30mg/g of glucosamine sulfate can be applied based on one’s requirements for about 8 weeks. To relieve respiratory congestion through inhalation, 1 tablespoon of Camphor for every quart of water should be placed in a vaporizer 3 times per day. The American Academy of Pediatrics suggests that Camphor should not exceed 11% for topical products and disqualifies the oral use of camphor in children as it may result in toxicity and death. Interactions There are no known mild, moderate or severe drug interactions associated with Camphor. However, if a doctor or pharmacist suggests that one can use camphor while on certain medications, then they are aware of potential drug interactions and they could be putting the patient on observation. One should always notify their doctor or pharmacist if they have health concerns or questions related to camphor. Side Effects Common side effects associated with Camphor include skin irritation and redness, burning sensation in the throat and mouth, vomiting, nausea, Lip dryness, rashes, eczema, seizures, respiratory issues, toxicity, scalp issues and chest problems. In pregnant or lactating mothers, camphor may result in physical and neurological damage to the developing fetus as it can be absorbed through the placenta. It can also be absorbed through the skin hence it can contaminate milk in lactating women. Camphor is considered exceptionally harmful for people with Parkinson’s disease as it interacts negatively with medications for Parkinson and it can result in high toxicity levels. Warning Cinnamomum camphora, Lodine and cemphire should not be prescribed to a person who is allergic to camphor or its constituent ingredients. Camphor is safe when used appropriately hence one should confirm that its composition in camphor products does not exceed 11%. A skin patch test is highly recommended before application of camphor products onto the skin. Camphor products should not be applied onto injured or broken skin as toxic levels of the product may be absorbed into the body. Camphor may also induce respiratory issues such as wheezing when inhaled. Description Camphor was recorded in the ancient books of traditional Chinese medicine, such as Pin Hui Jing Yao, Ben Cao Gang Mu, and Sheng Lian Fang. There has been a long history for traditional Chinese medicine to use camphor. Chemical Properties Both optical isomers are found widely in nature, with (+)-camphor being the more abundant. It is, for example, the main component of oils obtained from the camphor tree C. camphora. Camphor is produced by fractional distillation and crystallization of camphor oil or, synthetically, by dehydrogenation of isoborneol over a copper catalyst. Due to its characteristic penetrating, slightly minty odor, camphor is only used in perfuming industrial products. It is far more important as a plasticizer. Chemical Properties Camphor, C1oH160, also known as d-2-camphanone, Japan camphor, laurel camphor,Formosa camphor,and gumcamphor,is a terpene ketone. It is colourless solid with a characteristic odour that is obtained from the wood and bark of the camphor tree and is soluble in water and alcohol. It has two optically active forms (dextro and levo) and an optically inactive mixture (racemic) of these two forms. Camphor is used in pharmaceuticals,in disinfectants, in explosives,and to harden nitrocellulose plastics. Chemical Properties Camphor is a colorless glassy solid. Penetrating, characteristic odor. Physical properties Colorless to white, flammable granules, crystals or waxy semi-solid with a strong, penetrating, fragrant or aromatic odor. Odor threshold concentration is 0.27 ppm (quoted, Amoore and Hautala, 1983). History The research and development process of camphor has gone through from the natural product extraction to the modern chemical drug synthesis. For a long time, the Chinese extracted camphor mainly from camphor tree (Cinnamomum camphora), root bark of bodinier cinnamon, and Yunnan camphor tree. With the development of chemical industry, human beings started to use chemical synthesis methods to obtain a large amount of camphor. At present, the chemical synthesis process of camphor in China has been well developed. The synthetic camphor is divided into industrial and pharmaceutical grades. The industrial grade camphor has a content of up to 96% or higher, and the pharmaceutical grade camphor with high purity can meet the standard of pharmacopeia. Uses dl-Camphor is used as a plasticizer for celluloseesters and ethers; in the manufacture ofplastics and cymene; in cosmetics, lacquers,medicine, explosives, and pyrotechnics; andas a moth repellent. Uses Antipruritic. Uses camphor (Cinnamomum camphora) is credited with anesthetic, antiinflammatory, antiseptic, astringent, cooling, and refreshing properties, and thought to be slightly stimulating to blood circulation and function. once absorbed by the subcutaneous tissue, it combines in the body with glucoronic acid and is released through the urine. Camphor is effective for oily and acne skin treatment, and has a scent similar to eucalyptus. In high concentrations, it can be an irritant and numb the peripheral sensory nerves. natural camphor is derived from an evergreen tree indigenous to Asia, although now its synthetic substitute is often used. Definition A ketone occurring naturally in the wood of the cam- phor tree (Cinnamomum camphora). Definition A naturally- occurring white organic compound with a characteristic penetrating odor. It is a cyclic compound and a ketone, formerly obtained from the wood of the camphor tree but now made synthetically. Camphor is used as a platicizer for celluloid and as an insecticide against clothes moths. Definition camphor: A white crystalline cyclicketone, C10H16O; r.d. 0.99; m.p.179°C; b.p. 204°C. It was formerly obtainedfrom the wood of the Formosancamphor tree, but can now besynthesized. The compound has acharacteristic odour associated withits use in mothballs. It is a plasticizerin celluloid. Indications Camphor is a ketone which, when applied in 1% to 3% concentration, has mild antipruritic effects through its anesthetic and counterirritant properties. Counterirritants are substances that, by inducing other sensations such as coolness or warmth, ‘‘crowd out’’ the perception of pain or itch. Camphor is used in various OTC topical analgesic products in concentrations as high as 9%. Brand name Anbesol;Cresophene;Dasin;Ddd;Endrine;Makatussin;Mentol sedans sulfamidad;Nasello;Resol;Root bark oil;Spirit of camphor;Tcp;Tetesept;Topic. World Health Organization (WHO) Camphor, an aromatic crystalline substance with mild local anaesthetic activity, is available in preparations for both external application and inhalation. The use of such preparations has precipitated convulsions in susceptible infants. This has led several regulatory authorities to require the inclusion of appropriate warnings on labelling. Synthesis Reference(s) The Journal of Organic Chemistry, 41, p. 3329, 1976 DOI: 10.1021/jo00882a030 General Description A colorless or white colored crystalline powder with a strong mothball-like odor. About the same density as water. Emits flammable vapors above 150°F. Used to make moth proofings, pharmaceuticals, and flavorings. Air & Water Reactions Highly flammable. Slightly soluble in water. Reactivity Profile Naphthalene, Camphor, glycerol, or turpentine will react violently with chromic anhydride [Haz. Chem. Data 1967 p. 68]. Hazard Evolves flammable and explosive vapors when heated. Eye and upper respiratory tract irri- tant, and anosmia. Questionable carcinogen. Health Hazard Vapors of camphor can irritate the eyes, nose,and throat. In humans, such irritation may be felt at >3 ppm concentration. Prolongedexposure can cause headache, dizziness, andloss of sense of smell. Ingestion can causeheadache, nausea, vomiting, and diarrhea,and at high dosages can lead to convulsion,dyspnea, and coma. High dosages can beharmful to gastrointestinal tracts, kidney,and brain. LD50 value, intraperitoneal (mice): 3000mg/kg. Health Hazard Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

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Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

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