AZD-9291 CAS 1421373-65-0 Osimertinib

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Purity: 99%+

Keywords

AZD-9291 High Quality Osimertinib Factory Price AZD-9291

Quick Details

Appearance:White to off-white powder
Application:AZD9291 is an orally irreversible, selective mutant EGFR inhibitor with IC50s of 12.92, 11.44 and 493.8 nM for exon 19-deleted EGFR, L858R/T790M EGFR, and WT EGFR, respectively.
PackAge:bag or barrel or drum
ProductionCapacity:
Storage:Store at room temperature
Transportation:by express or air or sea

Superiority:

As a third-generation EGFR inhibitor, osimertinib is aimed at the subgroup of patients with EGFR T790M mutation to meet such unmet market needs: osimertinib has high selectivity, and is highly selective for T790M/L858R mutation and exon 19 deletion of EGFR. The IC50s were 11.4 nM and 12.9 nM, respectively, while the inhibitory activity against wild-type EGFR (IC50) was 494 nM. Osimertinib is an irreversible inhibitor of EGFR and can form covalent bonds with molecular targets, so theoretically the response lasts longer and the chance of drug resistance is reduced accordingly.

Details:

English name: AZD-9291
CAS number: 1421373-65-0
Molecular formula: C28H33N7O2
Molecular weight: 499.61
EINECS Number: 629-848-5
Melting point:>188oC(dec.)
Density: 1.19±0.1g/cm3(Predicted)
Storage conditions:Hygroscopic,-20°C Freezer,Under inert atmosphere
Dissolved: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
Acidity coefficient: (pKa) 12.68±0.70 (Predicted)
Form:Solid
Color: Pale Yellow to Beige

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