Steroid Hormone Powder CAS 167933-07-5 for women sexual enhancement Flibanserin

Superiority:

Name: Fluribansamide

Alias: 3-[2-[4-[4-(trifluoromethyl) phenyl] piperazine-1-yl] ethyl]-1H-benzimidazole-2-one; flurbanserin

English Name: Flibanserin

English alias: Bimt 17; 3-[2-[4-[4-(Trifluoromethyl) phenyl] piperazin-1-yl] ethyl]-1H-benzimidazol-2-one;

CAS No. 167933-07-5

Molecular formula: C20H21F3N4O

Molecular weight: 390.4021

Molecular structure: fluoride ribansamine 167933-07-5

Density: 1.292g/cm 3

Usage: Female Viagra, a drug used to improve female sexual desire, can reduce 5-hydroxytryptamine which inhibits sexual desire, in order to improve the level of dopamine which stimulates sexual desire.

Packaging Specification: 25kg/drum

 

 

Item	Specifications	Results
Assay(HPLC)	98.0%~102.0%	98.9%
Appearance	off-white fine powder	Complies
Identification	IR	Complies
Melting point	156.0~160.0℃	157.0~158.0℃
Loss on drying	≤0.5%	0.11%
Residue on ignition	≤0.1%	0.06%
Related substance	≤1.0%	0.75%
Heavy metals	≤10ppm	Complies

What is Flibanserin

Flibanserin is a new drug being investigated for the prevention of HSDD in woman. HSDD, is a relatively new term developed to describe Hypoactive Sexual Desire Disorder which basically means a woman whose is otherwise healthy has a lacking libido, or a lack of sexual desire. Studies show that about 10-20% of women face this problem and some say HSDD outnumbers men with sexual problems. Flibanserin is classified as a 5-HT serotonin receptor agonist and a dopamine D4 receptor partial agonist. It is a Non-Hormonal agent that in essence increases dopamine and noradrenalin while reducing Serotonin in the brain. This in return seemingly has a positive effect on a woman's sexual craving who was otherwise lacking in this area. The benefits of it being Non-Hormonal are that it will not have the problems associated with other hormonal treatments such as a negative altered mood among other issues.

Flibanserin Benefit:

This drug can directly effect on the sexual pleasure control area of the female brain to restore female Flagging libido. By adjusting the aphrodisiac body system, Flibanserin Helps to restore the balance of sexual appetite suppression and exciting mechanism and lead to form a healthy sexual performance. The curative effect can be obtained a few weeks later. At the same time, the female viagra also has a certain side effects. One-eighth of tested women appeared dizziness, fatigue and sleepiness.

Similar to antidepressants, Flibanserin will affect the brain secretion chemicals associated with emotions and desires. In fact, it was used as a drug for the treatment of depression before before it becomes a sex medicine.

Different from the working principle of "viagra", Flibanserin works by adjusting the chemicals in female brains.In addition, "viagra" only works for most men, Flibanserin has effects on women with low libido. If the patient does not have a sexual interest to someone, Flibanserin will not affect her. Flibanserin will not cause hyperaphrodisia. Clayton. Anita, adviser of the drug companies says :“it is not an aphrodisiac and it only helps to balance the chemicals in the female brain to make a female restore sex desire, but not more than the normal level. However, it takes some time for this drug to work and women should take the drug every day.

Flibanserin Function & Application:

Function:

Flibanserin is used for hypoactive sexual desire disorder among women. Those receiving flibanserin report a 0.5 increase compared to placebo in the number of times they had “satisfying sexual events”.In those on flibanserin it rose from 2.8 to 4.5 times a month while women receiving placebo reported also an increase of “satisfying sexual events” from 2.7 to 3.7 times a month.The onset of the flibanserin effect was seen from the first timepoint measured after 4 weeks of treatment and maintained throughout the treatment period.

The effectiveness of flibanserin was evaluated in three phase 3 clinical trials. Each of the three trials had two co-primary endpoints, one for satisfying sexual events (SSEs) and the other for sexual desire. Each of the 3 trials also had a secondary endpoint that measured distress related to sexual desire. All three trials showed that flibanserin produced an increase in the number of SSEs and reduced distress related to sexual desire. The first two trials used an electronic diary to measure sexual desire, and did not find an increase. These two trials also measured sexual desire using the Female Sexual Function index (FSFI) as a secondary endpoint, and an increase was observed using this latter measure. The FSFI was used as the co-primary endpoint for sexual desire in the third trial, and again showed a statistically significant increase.

Application:

Flibanserin, a drug used to increase female libido, reduces the suppression of sexually active serotonin to increase dopamine levels that stimulate libido. Low libido (HSDD) in premenopausal women shows good efficacy and tolerability. 

Flibanserin Dosage:

100 mg PO once daily at bedtime;Dosed at bedtime because administration during waking hours increases risks of hypotension, syncope, accidental injury, and CNS depression;Discontinued after 8 weeks if no improvement.

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