GMP factory 100% Safe Delivery CAS 104987-11-3 Tacrolimus
Min.Order / FOB Price:Get Latest Price
| 1 Gram |
FOB Price:USD 0.0200 -0.0300 |
- Min.Order :1 Gram
- Purity: 99%+
- Payment Terms : L/C,D/A,D/P,T/T,Other
Keywords
Tacrolimus Tacrolimus Impurity Tacrolimus Powder
Quick Details
- Appearance:White to off-white powder
- Application:CAS 104987-11-3 Macrolide antibiotics. Immunosuppressants. The mechanism of action is the same as that of cyclosporine, mainly inhibiting the synthesis of interleukin-2. Rejection for organ transplant
- PackAge:bag or barrel or drum
- ProductionCapacity:6000|Metric Ton|Day
- Storage:Store at room temperature
- Transportation:by express or air or sea
Superiority:
| Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. Tacrolimus was first extracted from the fermentation broth of Streptomyces tsukuba, a soil microbe found in Tsukuba, Japan.1 The name tacrolimus is derived by taking the ‘t’ for Tsukuba, the name of the mountain where the soil sample was extracted, ‘acrol’ for macrolide and ‘imus’ for immunosuppressant.[2] Although structurally unrelated to cyclosporin, tacrolimus shows a similar spectrum of immunosuppressive effects to this agent at the cellular and molecular level. Initial studies indicated that tacrolimus was a powerful immunosuppressant, displaying approximately 100-fold greater in vitro potency than cyclosporin in inhibiting T cell activation. Subsequent in vivo studies have shown tacrolimus to be effective both in suppressing spontaneous and experimental autoimmune disease, and in preventing allograft and xenograft rejection in animal models of organ transplantation. Initially, tacrolimus was used for systemic immunosuppression of patients who had undergone allograft transplants to stop them from rejecting their new grafts. Soon, however, through the benefit of the serendipity of science, it was noticed that tacrolimus could produce favorable results in skin disorders in some of the patients who had undergone transplantation. The discovery of tacrolimus has thus lead to greater understanding of skin pathology, for example of atopic dermatitis.[3] Subsequently, other topical applications of tacrolimus were reported and the use of this agent in dermatology is gradually expanding. |
|
Testing |
Specification |
Results |
|
Appearance
Identification
Water
Residue on Ignition
Heavy Metals
Related Substances
Residual Solvents
Assay (dried basis) |
White or almost white crystalline powder
IR HPLC
1.6% to 3.0%Max
0.2% Max
20 PPM Max
Ascomycin 0.8% Max Dihydrotacrolimus 0.6% Max Total Impurities 1.5% Max
Acetone 2000PPM Max Ethanol 2000PPM Max
98% to 102%
|
Conform
Conform Conform
2.3%
0.01%
Conform
0.050% 0.30% 0.43%
Not Detected Not Detected
99.0% |
|
Conclusion: Up to Standard for Export |
||
| tem | Specifications |
| Product Name | Melanotan II |
| Appearance | White freeze-dried powder |
| Purity | 99%min |
| Boiling point | 1265.3ºC at 760 mmHg |
| Density | 1.27 g/cm3 |
| Refractive index | 1.638 |
| Single Impurity (HPLC) | 1.0%max |
| Amino Acid Composition | ±10% of theoretical |
| Peptide Content (N%) | ≥80.0% |
| Water Content(Karl Fischer) | ≤6.0% |
| Acetate Content (HPIC) | ≤12.0% |
| MS(ESI) | Consistent |
| Mass Balance | 95.0~105.0% |
1. We has 11 years' exporting experience in pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.
2.We can provide you with ten thousands of products of different levels.
3. We offer convenient one-station purchasing service.
(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.
|
Tests |
Specifications |
Results |
|
Description |
A white or off-white crystalline powder |
Conform |
|
Identification |
1. IR (USP <197K>) |
Conform |
|
2. HPLC retention times |
Conform |
|
|
Water (USP <921> Method I) |
1.6 ~ 3.0% |
2.1% |
|
Residue on ignition (USP <281>) |
£ 0.2% |
0.08% |
|
Heavy metals (USP <231> II) |
£ 20 ppm |
< 20 ppm |
|
Related substances (In-house HPLC method) |
Ascomycin £ 0.8% |
0.064% |
|
Dihydrotacrolimus £ 0.6% |
0.089% |
|
|
Total impurities £ 1.5% |
0.15% |
|
|
Residual solvents (In-house method) |
Acetone £ 2000 ppm |
Not detected |
|
Ethanol £ 2000 ppm |
Not detected |
|
|
Assay (on anhydrous basis) |
98.0% ~ 102.0% |
100.0% |
|
Conclusion: Complied with In-House standard |
||
Details:
Wuhan Kanal Technology Co., Ltd. founded in 2010,it is a large manufacturer of fine Pharmaceutical& Chemical & Cosmetic materials that integrates R&D, production and sales together. Our Kanal company is established under the support of the Wuhan city government, so Kanal has large advantages in enterprise credit, finance security, product quality control, and cargo export.Kanal locates in the national new materials industry park of Wuhan city and is awarded the title of high-tech corporation.
Wuhan Kanal has its own R&D and development laboratory. We Kanal set up a R&D team with rich experience and strong technical strength, most of the practitioners have more than ten years' experience and technology in organic synthesis development. It owns almost 15 acre and more than 280 workers.
An ISO 9001 & GMP qualified company, we are mainly specialized in producing high quality but low price Pharmaceutical intermediates, APIs and other fine chemicals & cosmetics products which related to human and animals medicines as well as additives in gas &oil field, almost half of the goods are for exporting. What's more, we provide the OEM (customize) manufactures, if you can't find materials from the world, then tell us, we will research and produce in our high-tech equipmented laboratory. We are dedicated to satisfying our customers with our products and services.
1. We has 11 years' exporting experience in active pharmaceutical ingredient products.
Our professional and thoughtful after-sales service eliminates your worries.
2.We can provide you with ten thousands of products of different levels.
3. We offer convenient one-station purchasing service.
(1)Any inquiries will be replied within 12 hours.
(2)Dedication to quality, supply & service.
(3)Strictly on selecting raw materials.
(4)Reasonable & competitive price, fast lead time.
Our company is based on the optical valley biological city,making full use of the park policy advantages, focusing on the research and development of biological medicine.
The pharmaceutical intermediates are mainly applied to anti-cancer, anti-depression, cardiovascular, diabetes and other new medicine. The chemical intermediates mainly refer to heterocyclics and OLED intermediates.Our factory produce new fine chemical materials which are mainly used in water treatment, bactericidal and anti-corrosion, dyes, electronic materials and other industry fields.
Wuhan Kanal has export & import license, and hazard chemical sales license. The products are exported to America, Brazil, South Korea, Japan, Taiwan, Malaysia, Thailand, Indonesia, Europe union and other countries or regions.
Under rich experiences and excellent international reputation, the company becomes a quite influential enterprise in China's API field. Wuhan Kanal sincerely look forward to establishing long good cooperation with our customers from all over the world.
You Might Also Like
-
Zoledronic Acid / 2- (imidazole-1-yl) -1-Acetic Acid HCl / Cgp-42446 / Zoledronic Acid API / Small Amount / Aclasta / Orazol / Reclast CAS 118072-93-8
CAS NO:118072-93-8
-
(-)-Epinephrine(+)-bitartratesalt L-(–)-Epinephrine-(+)-bitartrate - CAS 51-42-3 - Calbiochem CAS 51-42-3 Epinephrine bitartrate
CAS NO:51-42-3
-
CAS 138071-82-6 Gadobutrol a Gadolinium-Based MRI Contrast Agent (GBCA)
CAS NO:138071-82-6
-
Factory Supply High Quality Paliperidone Palmitate CAS 199739-10-1
CAS NO:199739-10-1
-
L-4- (2-Amino-1-hydroxyethyl) -1, 2-Benzenediol Bitartrate CAS No. 69815-49-2 USP Standard
CAS NO:69815-49-2
-
Supply Acalabrutinib ACP-196 Powder CAS 1420477-60-6 Acalabrutinib
CAS NO:1420477-60-6
Related Searches
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View