Pharmaceutical Intermediate CAS 343306-79-6 Sugammadex Sodium

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Description

Sugammadex Sodium is the sodium salt form of the biologically inert, selective relaxant binding agent (SRBA) sugammadex, a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadexblocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade. Sugammadex binds rocuronium, vecuronium, and to a lesser extent pancuronium.

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Essential information of Sugammadex sodium CAS 343306-79-6

A selective relaxing antagonist that can be used to reverse neuromuscular blockers and is useful for antagonizing rocuronium or vecuronium-induced neuromuscular blockade
More information of Sugammadex sodium CAS 343306-79-6
Storage:It should be stored in a well-closed container at low temperature, keep away from moisture, heat and light.
 
Application of Sugammadex sodium CAS 343306-79-6
It can be used to reverse neuromuscular blockers and can be useful for antagonizing rocuronium or vecuronium-induced neuromuscular blockade.

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromines to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydrides or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxides to generate sugammadex sodium.
Chemical PropertiesColorless, orthorhombic crystals from DMF + water. d 1.446. Solubility in water.
UsesReversal agent for neuromuscular blocking drugs.

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