Min.Order / FOB Price:Get Latest Price
1 Kilogram |
FOB Price: USD 200.0000 |
Retinoic acid 302-79-4 302-79-4 In Medicine 302-79-4 Best Price
Product Name: Retinoic acid
Synonyms: Tretinoin Retinoic acid in stock Factory;Isotretinoin Impurity 1(Isotretinoin EP Impurity A);TRETINOIN;TRETINOIN VITAMIN A ACID;TRANS-RETINOIC ACID;TRANS VITAMIN A ACID;VITAMIN A ACID;VITAMIN A ACID, ALL-TRANS
CAS: 302-79-4
MF: C20H28O2
MW: 300.44
EINECS: 206-129-0
Product Categories: Intracellular receptor;API;intermediates;Inhibitors;PHARMACEUTICALS;Active Pharmaceutical Ingredients;APIs;Biochemistry;Terpenes;Terpenes (Others);Vitamins;Intermediates & Fine Chemicals;Retinoids
Mol File: 302-79-4.mol
Retinoic acid Chemical Properties
Melting point 180-181 °C(lit.)
Boiling point 381.66°C (rough estimate)
density 1.0597 (rough estimate)
refractive index 1.4800 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
pka 4.73±0.33(Predicted)
form powder
color yellow
Water Solubility insoluble
Sensitive Light Sensitive
Merck 14,8165
BRN 2057223
Stability: Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
InChIKey SHGAZHPCJJPHSC-ZVCIMWCZSA-N
CAS DataBase Reference 302-79-4(CAS DataBase Reference)
EPA Substance Registry System Retinoic acid (302-79-4)
Safety Information
Hazard Codes T,Xn,N
Risk Statements 22-63-38-20/21/22-51/53
Safety Statements 53-26-36/37/39-45-36/37-61-24/25
RIDADR 3249
WGK Germany 3
RTECS VH6475000
F 7-8-16-23
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29362100
Hazardous Substances Data 302-79-4(Hazardous Substances Data)
Toxicity LD50 (10 day) in mice, rats (mg/kg): 790, 790 i.p.; 2200, 2000 orally (Kamm)
Retinoic acid Usage And Synthesis
Dermatology drugs Retinoic acid(Tretinoin) is commonly used in dermatology drugs, which is the department of vitamin A (Victoria methanol) metabolic intermediates.It mainly affects the growth of bones and epithelial metabolism, can promote epithelial cell proliferation and updates, and can inhibit the proliferation and differentiation of keratinocytes, so hyperkeratosis can be back to normal. Therefore many complete or incomplete keratosis, hyperkeratosis of diseases have a certain therapeutic effect, treat a variety of skin diseases. The use of the drug can penetrate topical skin quickly, enable significantly increased epithelial cell turnover. This class of drugs has strong and rapid inhibition on the secretion of the sebaceous glands, can reduce sebum secretion. In addition, the product also has anti-tumor, promote wound healing and anti-inflammatory effects.
Clinical application Retinoic acid is mainly used in the treatment of psoriasis, ichthyosis, follicular keratosis, acne, lichen planus, verrucous epidermal nevus, impetigo, vitiligo, lichen psoriasis, the face of pityriasis alba, etc. In addition, the drugs also have some preventive effect on skin cancer.
Physicochemical property Retinoic acid is a yellow needle crystal, with a similar smell of vitamin acetate. Soluble in methanol, ethanol, dichloromethane , also in vegetable oil and fatty. In case of light, it is thermal instability, suck up moisture in the air, polymerization and metamorphism in water. The melting point of all trans-vitamin A acid is 182~180°C, the melting range of which is mixed with a small amount of isomers is 170~190°C.
CAS NO:29911-28-2
CAS NO:32435-46-4
CAS NO:9046-10-0
CAS NO:307297-39-8
CAS NO:114435-02-8
CAS NO:10497-05-9
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View