Pharmaceutical Material Antiulcer Betahistine Dihydrochloride CAS 5579-84-0

Superiority:

Specification of Analysis

What is Betahistine dihydrochloride

Betahistine dihydrochloride is a histamine H3 receptors inhibitor used as an antivertigo drug. Target: Histamine Receptor Betahistine dihydrochloride, a structural analogue of histamine with weak histamine H(1) receptor agonist and more potent H(3) receptor antagonist properties. Betahistine dihydrochloride acts centrally by enhancing histamine synthesis within tuberomammillary nuclei of the posterior hypothalamus and histamine release within vestibular nuclei through antagonism of H(3) autoreceptors [1]. Therapeutic effects of betahistine in vestibular disorders result from its antagonist properties at histamine H(3) receptors (H(3)Rs). On inhibition of cAMP formation and [(3)H]arachidonic acid release, betahistine behaved as a nanomolar inverse agonist and a micromolar agonist. After acute oral administration, Betahistine increased t-MeHA levels with an ED(50) of 2 mg/kg, a rightward shift probably caused by almost complete first-pass metabolism. Therapeutic effects of betahistine result from an enhancement of histamine neuron activity induced by inverse agonism at H(3) autoreceptors [2].

Fuction and Application of Betahistine dihydrochloride

1.Betahistine (16 mg, twice a day for 3 months continuously) can significantly improve the frequency, intensity and duration of vertigo and its complications, as well as the quality of life of patients with meniere's disease. 
2.Betahistine - dihydrochloride (16 mg each time, three times a day or 48 mg), longer duration of use, two doses can be reduced the number of meniere's disease patient monthly .

Application

1. Applied in food field;
2. Applied in health food field;
3. Applied in pharmaceutical field.

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